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Erschienen in: Head and Neck Pathology 1/2012

01.03.2012 | Case Report

Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology

verfasst von: Fredrik Petersson, Derrick Lian, Yuk Ping Chau, Benedict Yan

Erschienen in: Head and Neck Pathology | Ausgabe 1/2012

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Abstract

We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I–IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1–3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months.
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Metadaten
Titel
Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology
verfasst von
Fredrik Petersson
Derrick Lian
Yuk Ping Chau
Benedict Yan
Publikationsdatum
01.03.2012
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2012
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-011-0283-x

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