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Head and Neck Pathology

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01.06.2012 | Case Report

Solitary Langerhans Histiocytosis of the Thyroid Gland: A Case Report and Literature Review

verfasst von: Darren K. Patten, Zubair Wani, Neil Tolley

Erschienen in: Head and Neck Pathology | Ausgabe 2/2012

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Abstract

Langerhans cell histiocytosis (LCH) is a rare disease of antigen presenting cells, with an incidence rate of 4.0–5.4 per 1 million individuals. The most common endocrinological manifestation of classical LCH is associated with the posterior pituitary, presenting as Diabetes Insipidus. However, LCH can affect multiple organs and classification is based on the body system involvement. The disease is confirmed by electron microscopy or immunohistochemical reactivity of histiocytes to CD1a and/or S100. LCH rarely involves the thyroid gland, and management of such disease is controversial. Current literature documents 65 English language reported cases of LCH involving the thyroid gland. We present an unusual case of LCH of the thyroid gland, with variable diagnoses on fine needle aspiration (FNA) cytology, and literature review of all English reported cases.

Donadieu J, Rolon MA, Thomas C, et al. Endocrine involvement in pediatric-onset Langerhans’ cell histiocytosis: a population-based study. J Pediatr. 2004;144(3):344–50.PubMedCrossRef

Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP. Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol. 2008;29:201–4.PubMedCrossRef

Behrens RJ, Levi AW, Westra WH, Dutta D, Cooper DS. Langerhans cell histiocytosis of the thyroid: a report of two cases and review of literature. Thyroid. 2001;11:697–705.PubMedCrossRef

Panayotopoulos E, Concouris L, Roussis S, Sinacos Z. Eosinophilic granuloma of the thyroid gland with diabetes insipidus. Presse Med. 1964;18:153–4.

Wilkins L. The diagnosis and treatment of endocrine disorders in childhood and adolescence. Springfield: Charles C Thomas Publications Ltd; 1965. p. 157.

Whitaker C, Kenny FM, Fetterman GH. Asymptomatic goiter as an expression of a rare disease. Clin Pediatr. 1971;10:290–2.CrossRef

Rothman JG, Snyder PJ, Utiger RD. Hypothalamic endocrinopathyin Hand-Schuller-Christian Disease. Ann Intern Med. 1978;88:512–3.PubMed

Mahzoon S, Wood MG. Multifocal eosinophilic granuloma with skin ulceration. Arch Dermatol. 1980;116:218–20.PubMedCrossRef

Teja K, Sabio H, Langdon DR, Johanson AJ. Involvement of the thyroid gland in histiocytosis X. Hum Pathol. 1981;12:1137–9.PubMedCrossRef

10.

Deméocq F, Boespflug O, Vanlieferinghen P, Jourdan JE, Lesec G, Malpuech G. Thyroid involvement in histiocytosis X. Arch Fr Pediatr. 1982;39:449–54. [French].PubMed

11.

Pastor Durán X, Palomeque Rico A, Cruz Hernández M. Histiocytosis X with thyroid involvement. An Esp Pediatr. 1984;20(8):818–20.PubMed

12.

Ma JT, Ho FC, Wang C, Lam KS, Yeung RT. Primary hypothyroidism and essential hypernatremia in a patient with histiocytosis X. Aust NZ J Med. 1985;15:72–4.CrossRef

13.

Lahey ME, Rallison ML, Hilding DA, Ater J. Involvement of the thyroid in histiocytosis X. Am J Pediatr Hematol Oncol. 1986;8:257–8.PubMedCrossRef

14.

Sinisi AA, Criscuolo T, Palombini L, Bellastella A, Faggiano M. Thyroid localization in adult histiocytosis X. J Endocrinol Invest. 1986;9:417–20.PubMed

15.

Green I, Behar AJ, Shanon E, Gorsky M. Multifocal extraosseous eosinophilic granuloma of the head and neck. Arch Otolaryngol Head Neck Surg. 1988;114:561–3.PubMedCrossRef

16.

Gaines P, Chan JCN, Cockram CS. Histiocytosis X involving the thyroid and hypothalamus. Postgrad Med J. 1991;67:680–2.PubMedCrossRef

17.

Goldstein N, Layfield LJ. Thyromegaly secondary to simultaneous papillary carcinoma and histiocytosis X. Acta Cytol. 1991;35:422–6.PubMed

18.

Ho KH, Chong AP, Thai AC. Langerhans cell histiocytosis presenting as a goitre: a case report. Ann Acad Med Singapore. 1993;22:598–602.PubMed

19.

Kirchgraber PR, Weaver MG, Arafah BM, Abdul-Karim FW. Fine needle aspiration cytology of Langerhans cell histiocytosis involving the thyroid. Acta Cytol. 1994;38:101–6.PubMed

20.

Liu CS, Chin TW, Fahn HJ, Wei CF. Histiocytosis X involving thyroid gland. Chin Med J (Taipei). 1994;54:279–81.

21.

Maurea S, Lastoria S, Klain M, Brunetti A, Boscaino A, Lupoli G, Salvatore M. Diagnostic evaluation of thyroid involvement by histiocytosis X. J Nucl Med. 1994;35:263–5.PubMed

22.

Tsang WY, Lau MF, Chan JK. Incidental Langerhans’ cell histiocytosis of the thyroid. Histopathology. 1994;24:397–9.PubMedCrossRef

23.

Chong VFH. Langerhans cell histiocytosis with thyroid involvement. Eur J Radiol. 1996;22:155–7.PubMedCrossRef

24.

Kitahama S, Iitaka M, Shimizu T, Serizawa N, Fukasawa N, Miura S, Kawasaki S, Yamanaka K, Kawakami Y, Murakami S, Ishii J, Katayama S. Thyroid involvement by malignant histiocytosis of Langerhans’ cell type. Clin Endocrinol (Oxf). 1996;45:357–63.CrossRef

25.

Gomez-Plaza MC, Castella E, Lucas A, Llatjos M. Histiocytosis X of the thyroid [letter]. Acta Cytol. 1996;40:618–9.PubMed

26.

Orabona P, D’Antonio A, Boscaino A, Tornillo L, Staibano S, De Rosa G. Histiocytosis X of the thyroid gland. Tumori. 1996;82:252–5.PubMed

27.

Thompson LD. Langerhans cell histiocytosis isolated to the thyroid gland. Eur Arch Otorhinolaryngol. 1996;253:62–5.PubMedCrossRef

28.

Thompson LD, Wenig BM, Adair CF, Smith BC, Heffess CS. Langerhans cell histiocytosis of the thyroid: a series of seven cases and a review of the literature. Mod Pathol. 1996;9:145–9.PubMed

29.

Wang WS, Liu JH, Chiou TJ, Hsieh RK, Yen CC, Chen PM. Langerhans cell histiocytosis with thyroid involvement masquerading as thyroid carcinoma. Jpn J Clin Oncol. 1997;27:180–4.PubMedCrossRef

30.

Coode PE, Shaikh MU. Histiocytosis X of the thyroid masquerading as thyroid carcinoma. Hum Pathol. 1998;19:239–41.CrossRef

31.

Diamond FB, Shulman DI, Lacson A, Casadonte J, Favara B. Atypical dendritic cell-related histiocytosis with goiter and primary hypothyroidism. J Pediatr. 1998;132:357–60.PubMedCrossRef

32.

Sahoo M, Karak AS, Bhatnagar D, Bal CS. Fine-needle aspiration cytology in a case of isolated involvement of thyroid with Langerhans cell histiocytosis. Diagn Cytopathol. 1998;19:33–7.PubMedCrossRef

33.

Dey P, Luthra UK, Sheikh ZA. Fine needle aspiration cytology of Langerhans cell histiocytosis of the thyroid. Acta Cytol. 1999;43:429–31.PubMedCrossRef

34.

Saiz E, Bakotic B. Isolated Langerhans cell histiocytosis of the thyroid: a report of two cases with nuclear imagingpathologic correlation. Ann Diagn Pathol. 2000;4:23–8.PubMedCrossRef

35.

el-Halabi DA, el-Sayed M, Eskaf W, Anim JT, Dev P. Langerhans cell histiocytosis of the thyroid gland. A case report. Acta Cytol. 2000;44:805–8.PubMedCrossRef

36.

Yap WM, Chuah KL, Tan PH. Langerhans cell histiocytosis invovling the thyroid and parathyroid glands. Mod Pathol. 2001;14:111–5.PubMedCrossRef

37.

Mrad K, Abbes I, Ben Salah H, Ben Amor MH, Sassi S, Ben Romdhane K. Langerhans cell histiocytosis of the thyroid: a rare disease not to be ignored. Ann Pathol. 2002;22:35–8. [French].PubMed

38.

Sampathkumar S, Younger C, Cramer H, Chalasani N, Skierczynski PA. Langerhans’ cell histiocytosis involving the pituitary, thyroid, lung and liver. Endocr Pract. 2002;8:217–21.PubMed

39.

Foulet-Rogé A, Josselin N, Guyetant S, Gardet JJ, Besancon A, Saint-André JP, Fabiani B. Incidental langerhans cell histiocytosis of the thyroid: case report and review of literature. Endocr Pathol. 2002;13:227–33.PubMedCrossRef

40.

Chern MS, Ko JS, Wu MH, Tsai TT, Li WY, Teng MM, Chou YH, Chang CY, Chang SC. Pulmonary langerhans cell granulomatosis with extrapulmonary involvement. J Chin Med Assoc. 2004;67:41–7.PubMed

41.

Zhu H, Hu DX. Langerhans cell histiocytosis of the thyroid diagnosed by fine needle aspiration cytology. A case report. Acta Cytol. 2004;48:278–80.PubMedCrossRef

42.

Khiari K, Ben Abdallah N, Cherif L, Maazoun I, Hadj-Ali I, Ben Maiz H, Rajhi H, Tanazakti F, Ouertani L, Ferjaoui M, Ben Ayed F. Infiltration of thyroid gland by Langerhans cell histiocytosis in adult “case report”. Rev Med Interne. 2003;24:838–9. [French].PubMedCrossRef

43.

Elliott DD, Sellin R, Egger JF, Medeiros LJ. Langerhans cell histiocytosis presenting as a thyroid mass. Ann Diagn Pathol. 2005;9:267–74.PubMedCrossRef

44.

Braiteh F, Kurzrock R. CASE 1. Langerhanscell histiocytosis of the thyroid. J Clin Oncol. 2006;24:522–3.PubMedCrossRef

45.

Oudidi A, Hachimi H, El Alami MN. Langerhans cell histiocytosis of the thyroid. Presse Med. 2006;35:977–9. [French].PubMedCrossRef

46.

Kamińska H, Korpal-Szczyrska M, Połczyńska K, Dorant B, Birkholz D. Endocrinology complications of langerhans cell histiocytosis. Przegl Lek. 2005;62:1577–9. [Polish].PubMed

47.

Calès V, Belleannée G, Laborde Y, Razakandretsa R, Lequen L. An unusual thyroid. Ann Pathol. 2006;26:131–3. [French].PubMedCrossRef

48.

Burnett A, Carney D, Mukhopadhyay S, Scalzetti EM, Leino D, Souid AK. Thyroid involvement with Langerhans cell histiocytosis in a 3-year-old male. Pediatr Blood Cancer. 2008;50:726–7.PubMedCrossRef

49.

Oudidi A, Hachimi H, El Alami MN. Langerhans cell histiocytosis of the thyroid. Ann Endocrinol (Paris). 2006;67:620–3. [French].CrossRef

50.

Ma J, Shi HW, Ma XL. One case about Langerhans cell histiocytosis involving the thyroid in children. Zhonghua Er Ke Za Zhi. 2006;44:791. [Chinese].PubMed

51.

Hung CS, Yeh YC, Chen JC, Jung SM, Hung IJ, Lo FS. Isolated langerhans cell histiocytosis of the thyroid in a female infant. Eur J Pediatr. 2007;166:1151–3. Epub 2007 Mar 20.PubMedCrossRef

52.

Yağci B, Kandemir N, Yazici N, Yalçin B, Varan A, Akyüz C, Büyükpamukçu M. Thyroid involvement in Langerhans cell histiocytosis : a report of two cases and review of literature. Eur J Pediatr. 2007;166:901–4. Epub 2007.PubMedCrossRef

53.

Giovanella L, Ceriani L, Crippa S, Mazzucchelli L. Imaging in endocrinology: langerhans cell histiocytosis of the thyroid gland detected by 18FDG-PET/CT. J Clin Endocrinol Metab. 2007;92:2866–7.PubMedCrossRef

54.

Deepak DS, Woodcock BE, Macfarlane IA. A thyroid mass composed of Langerhans’ cell histiocytosis and auto-immune thyroiditis associated with progressive hypothalamic-pituitary failure. Int J Clin Pract. 2007;61:2130–1.PubMedCrossRef

55.

Licci S, Boscaino A, De Palma M, Del Nonno F, D’Antonio A. Concurrence of marginal zone B-cell lymphoma MALT-type and Langerhans cell histiocytosis in a thyroid gland with Hashimoto disease. Ann Hematol. 2008;87:855–7.PubMedCrossRef

56.

Ramadas PT, Kattoor J, Mathews A, Abraham EK. Fine needle aspiration cytology of Langerhans cell thyroid histiocytosis and its draining lymph nodes. Acta Cytol. 2008;52:396–8.PubMedCrossRef

57.

Lassalle S, Hofman V, Santini J, Sadoul JL, Hofman P. Isolated langerhans cell histiocytosis of the thyroid and Graves’ disease: an unreported association. Pathology. 2008;40:525–7.PubMedCrossRef

58.

Wohlschlaeger J, Ebert S, Sheu SY, Schmid KW, Totsch M. Immunocytochemical investigation of Langerin (CD207) is a valuable adjunct in the diagnosis of Langerhans cell histiocytosis of the thyroid. Pathol Res Pract. 2009;205:433–6.PubMedCrossRef

59.

Jamaati HR, Shadmehr MB, Saidi B, Khosravi A, Arab M, Mohammadi F. Langerhans cell histiocytosis of the lung and thyroid, co-existing with papillary thyroid cancer. Endocr Pathol. 2009;20:133–6.PubMedCrossRef

60.

Shima H, Inokuchi M, Shimada H. A case of multisystem Langerhans cell histiocytosis with primary hypothyroidism followed by type 1 diabetes mellitus. Pediatr Blood Cancer. 2009;53:232–4.PubMedCrossRef

61.

Uchiyama M, Watanabe R, Ito I, Ikeda T. Thyroid involvement in pulmonary Langerhans cell histiocytosis. Intern Med. 2009;48:2047–8.PubMedCrossRef

62.

Lin CH, Lin WC, Chiang IP, Ho YJ, Peng CT, Wu KH. Langerhans cell histiocytosis with thyroid and lung involvement in a child: a case report. J Pediatr Hematol Oncol. 2010;32:309–11.PubMedCrossRef

63.

García Gallo MS, Martínez MP, Abalovich MS, Gutiérrez S, Guitelman MA. Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults. Pituitary. 2010;13:298–303.PubMedCrossRef

64.

Vergez S, Rouquette I, Ancey M, Serrano E, Caron P. Langerhans cell histiocytosis of the thyroid is a rare entity, but an association with a papillary thyroid carcinoma is often described. Endocr Pathol. 2010;21:274–6.PubMedCrossRef

65.

Priyambada L, Bhatia V, Krishnani N, Agarwal V, Bhattacharyya A, Jain S, Mishra SK, Marwaha RK. Primary hypothyroidism, precocious puberty and hypothalamic obesity in Langerhans cell histiocytosis. Indian J Pediatr. 2011;78:351–3.PubMedCrossRef

66.

Vilallonga R, Ciudin A, Fort JM, Baena JA, Gonzalez O, Armengol M, Mesa J, Ruiz Marcellán MC. Isolated Langerhans cell histiocytosis of the thyroid in an adult female: one-year followup. Int J Endocrinol. 2011;2011:898302. doi:10.1155/2011/898302.

67.

Hand J. Polyuria and tuberculosis. Arch Pediatr. 1893;10:673.

68.

Rami B, Schneider U, Wandl-Vergesslich K, Frisch H, Schober E. Primary hypothyroidism, central diabetes insipidus and growth hormone deficiency in multisystem Langerhans cell histiocytosis: a case report. Acta Paediatr Int J Paediatr. 1998;87:112–4.CrossRef

69.

Ng-Cheng-Hin B, O’Hanlon-Brown C, Alifrangis C, Waxman J. Langerhans cell histiocytosis: old disease new treatment. QJM. 2011;104(2):89–96.PubMedCrossRef

70.

Nezelof C, Basset F, Rousseau MF. Histiocytosis X histogenetic arguments for a Langerhans cell origin. Biomedicine. 1973;18:365–71.PubMed

71.

Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Engleman EG. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol. 2002;3:1135–41.PubMedCrossRef

72.

Willman CL, Busque L, Griffith BB, Favara BE, McClain KL, Duncan MH, Gilliland DG. Langerhans cell histiocytosis (histiocytosis X)–A clonal proliferative disease. N Engl J Med. 1994;331(3):154–60.PubMedCrossRef

73.

Yu RC, Chu C, Buluwela L, Chu AC. Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis. Lancet. 1994;343:767–8.PubMedCrossRef

74.

Selch MT, Parker RG. Radiation therapy in the management of Langerhans cell histiocytosis. Med Pediatr Oncol. 1990;18:97–102.PubMedCrossRef

75.

Broadbent V, Gadner H. Current therapy for Langerhans cell histiocytosis. Hematol Oncol Clin North Am. 1998;12:327–38.PubMedCrossRef

76.

Saven A, Foon KA, Piro LD. 2-Chlorodeoxyadenosine-induced complete remissions in Langerhans-cell histiocytosis. Ann Intern Med. 1994;121(6):430–2.PubMed

77.

Malpas JS. Langerhans cell histiocytosis in adults. Hematol Oncol Clin North Am. 1998;12:259–68.PubMedCrossRef

Titel: Solitary Langerhans Histiocytosis of the Thyroid Gland: A Case Report and Literature Review
verfasst von: Darren K. Patten
Zubair Wani
Neil Tolley
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2012
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-011-0321-8

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Solitary Langerhans Histiocytosis of the Thyroid Gland: A Case Report and Literature Review

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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