Erschienen in:
01.12.2014 | Update in Gnathic Pathology. Guest Editors: Angela Chi, DMD and John Wright, DDS
Fibro-Osseous Lesions of the Craniofacial Skeleton: An Update
verfasst von:
Samir K. El-Mofty
Erschienen in:
Head and Neck Pathology
|
Ausgabe 4/2014
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Abstract
Benign fibro-osseous lesions of the craniofacial skeleton (BFOL) are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementum-like tissue and other calcified structures [
1‐
6]. Whereas some are diagnosable histologically, most require a combined assessment of clinical, microscopic and radiologic features. Some BFOL of the craniofacial complex are unique to that location whereas others are encountered in bones from other regions. Reactive, neoplastic, developmental and dysplastic pathologic processes are included under the rubric of BFOL and treatment varies from disease to disease. This review will discuss the clinical, microscopic and radiologic aspects of the more important types of BFOL of the craniofacial complex with updated information on underlying genetic and molecular pathogenic mechanisms of disease. Four main groups of BFOLs will be addressed.