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Head and Neck Pathology

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05.03.2020 | Historical Perspectives in Pathology

Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems—A Short Review

verfasst von: Nina Gale, Antonio Cardesa, Juan C. Hernandez-Prera, Pieter J. Slootweg, Bruce M. Wenig, Nina Zidar

Erschienen in: Head and Neck Pathology | Ausgabe 4/2020

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Abstract

We present the historical review and current state of the histopathological classifications and terminology of laryngeal precursor lesions. Attention to recent genetic findings is also presented; although in need of additional confirmation, these raise possibility for early detection of patients at risk of dysplasia progression. Although a number of identified genetic alterations with a promising diagnostic and prognostic value are emerging, none of the known genetic alterations can be currently implemented in clinical practice as a completely reliable diagnostic and/or prognostic marker. Regarding the terminology of precursor lesions, dysplasia remains the most frequently used term, but squamous intraepithelial lesion can be used as a synonym as well. Histological findings, in spite of certain degree of subjectivity, remain at present the most reliable method for an accurate diagnosis. The current 2017 WHO classification seems to successfully stratify risk of malignant progression, with a significantly different risk of malignant progression between low-grade dysplasia and high-grade dysplasia. In case of pronounced architectural disorders, severe cellular and nuclear atypias, and an increased number of mitoses, also atypical form, the high-grade dysplasia and carcinoma in situ can be separated. The Slovenian tertiary centers have a policy of surgical removal of high-grade SILs and life-long close follow-up. Radiotherapy is reserved for more pronounced intraepithelial lesions classified as carcinoma in situ and invasive cancer. Such a distinction can facilitate clinical decision to use radiotherapy if complete surgical removal is not possible.

Kambič V, Gale N. Epithelial hyperplastic lesions of the larynx. Amsterdam: Elsevier; 1995. p. 1–265.

Barnes L. Diseases of the larynx, hypopharynx, and trachea. In: Barnes L, editor. Surgical Pathology of the head and Neck. 3rd ed. New York: Informa Health Care; 2009. p. 109–200.

Fleskens S, Slootweg P. Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility. Head Neck Oncol. 2009;11(1):11.

Gale N, Blagus R, El-Mofty SK, Helliwell T, Prasad ML, Sandison A, et al. Evaluation of a new grading system for laryngeal squamous intraepithelial lesions: a proposed unified classification. Histopathology. 2014;65(4):456–64.PubMed

Wenig BM. Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants. Mod Pathol. 2017;30(s1):S112–8.PubMed

Network Cancer Genome Atlas. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517:576–82.

Rodrigo JP, Villaronga MÁ, Menéndez ST, Hermida-Prado F, Quer M, Vilaseca I, et al. A Novel role for Nanog as an early cancer risk marker in patients with laryngeal precancerous lesions. Sci Rep. 2017;7(1):11110.PubMedPubMedCentral

Manterola L, Aguirre P, Larrea E, Arestín M, Gaafar A, Elorriaga K, et al. Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma. Sci Rep. 2018;8(1):6613.PubMedPubMedCentral

Leemans CR, Snijders PJF, Brakenhoff RH. The molecular landscape of head and neck cancer. Nat Rev Cancer. 2018;18(5):269–82.PubMed

10.

Kleinsasser O. The classification and differential diagnosis of epithelial hyperplasia of the laryngeal mucosa on the basis of histomorphological features. II] [Article in German]. Z Laryngol Rhinol Otol. 1963;42:339–62.PubMed

11.

Kambič V, Lenart I. Our classification of hyperplasia of the laryngeal epithelium from the prognostic point of view [Article in French]. J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1971;20(10):1145–50.PubMed

12.

Reagan JW, Seidemann IL, Saracusa Y. The cellular morphology of carcinoma in situ and dysplasia or atypical hyperplasia of the uterine cervix. Cancer. 1953;6(2):224–34.PubMed

13.

Miller AH. Premalignant laryngeal lesions, carcinoma in situ, superficial carcinoma-definition and management. Can J Otolaryngol. 1974;3(4):573–5.PubMed

14.

Friedmann I. Precancerous lesions of the larynx. Can J Otolaryngol. 1974;3(4):528–32.PubMed

15.

Shanmugaratnam K, Sobin LH. pathologists in 10 countries. Histological typing of upper respiratory tract tumours. Geneva: World Health Organization; 1978.

16.

Shanmugaratnam K, Sobin LH, Pathologists in 8 countries. Histological typing of tumours of the upper respiratory tract and ear. 2nd edn. Berlin: Springer, 199. pp: 1-200.

17.

Hellquist H, Lundgren J, Olofsson J. Hyperplasia, keratosis, dysplasia and carcinoma in situ of the vocal cords: a follow-up study. Clin Otolaryngol Allied Sci. 1982;7(1):11–27.PubMed

18.

Blackwell KE, Fu YS, Calcaterra TC. Laryngeal dysplasia. A Clinicopathologic study. Cancer. 1995;75(2):457–63.PubMed

19.

Richart RM, Barron BA. A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol. 1969;105(3):386–93.PubMed

20.

Darragh TM, Colgan TJ, Cox JT, Heller DS, Henry MR, Luff RD, Members of LAST project work groups, et al. The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Arch Pathol Lab Med. 2012;136(10):1266–97.PubMed

21.

Friedmann I, Osborn DA. The larynx. In: Symmers WSTC, editor. Systemic pathology. 3rd ed. Edinburgh: Churchill Livingstone; 1976.

22.

Crissman JD, Fu YS. Intraepithelial neoplasia of the larynx: a clinicopathologic study of six cases with DNA analysis. Arch Otolaryngol Head Neck Surg. 1986;112(5):522–8.PubMed

23.

Friedmann I, Ferlito A. Precursors of squamous cell carcinoma. In: Ferlito A, editor. Neoplasms of the larynx. Edinburgh: Churchill Livingstone; 1993. p. 97–111.

24.

Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, et al. Squamous epithelial changes of the larynx: diagnosis and therapy. Head Neck. 2012;34(12):1810–6.PubMed

25.

Kurita T, Chitose SI, Sato K, Sakazaki T, Fukahori M, Sueyoshi S, et al. Pathological mechanisms of laryngeal papillomatosis based on laryngeal epithelial characteristics. Laryngoscope Investig Otolaryngol. 2019;4(1):89–94.PubMedPubMedCentral

26.

Gale N, Pilch BZ, Sidransky D, Westra WH, Califano J. Epithelial precursor lesions. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology and genetics of head and neck tumours. 3rd ed. Lyon: IARC Press; 2005. p. 140–3.

27.

McLaren KM, Burnett RA, Goodlad JR, Howatson SR, Lang S, Lee FD, Scottish Pathology Consistency Group, et al. Consistency of histopathological reporting of laryngeal dysplasia. The Scottish Pathology Consistency Group. Histopathology. 2000;37(5):460–3.PubMed

28.

Fleskens SA, Bergshoeff VE, Voogd AC, van Velthuysen ML, Bot FJ, Speel EJ, et al. Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation. Mod Pathol. 2011;24(7):892–8.PubMed

29.

Sarioglu S, Cakalagaoglu F, Elagoz S, Han U, Etit D, Hucumenoglu S, et al. Inter-observer agreement in laryngeal pre-neoplastic lesions. Head Neck Pathol. 2010;4(4):276–80.PubMedPubMedCentral

30.

Thompson LDR. Laryngeal dysplasia, squamous cell carcinoma, and variants. Surg Pathol. 2017;10(1):15–33.

31.

Gale N, Hille J, Jordan RC, Nadal A, Williams MD. Precursor Lesions. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. Lyon: IARC; 2017. p. 91–3.

32.

Dutch Cooperative Head and Neck Oncology Group. NWHHTCBO revision guidelines laryngeal carcinoma. Alphen aan de Rijan, The Netherlands Van Zuiden Communications, 2009.

33.

Takubo K, Fuji S. Oesophageal squamous dysplasia. In: Odze RD, Lam AK, Ochiai A, Washington MK, editors. WHO classification of tumours editorial bord. Digestive system tumours. Lyon: IARC; 2019. p. 36–7.

34.

Reibel J, Gale N, Hille J, Hunt JL, Lingen M, Muller S, et al. Oral potential malignant disorders and oral dysplasia. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours. Lyon: IARC; 2017. p. 112–5.

35.

Mehlum CS, Larsen SR, Kiss K, Groentved AM, Kjaergaard T, Möller S, et al. Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment. Laryngoscope. 2018;128(10):2375–9.PubMed

36.

Cho KJ, Song JS. Recent Changes of classification for squamous intraepithelial lesions of the head and neck. Arch Pathol Lab Med. 2018;142(7):829–32.PubMed

37.

Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol. 2010;35(5):364–72.PubMed

38.

Kumar V, Abbas AK, Aster JC. Robbins and Cotran pathologic basis of disease. 2nd ed. Philadelphia: Elsevier; 2015. p. 265–340.

39.

Resta L, Colucci GA, Troia M, Russo S, Vacca E, Pesce Delfino V. Laryngeal intraepithelial neoplasia (LIN). An analytical morphometric approach. Pathol Res Pract. 1992;188(4–5):517–23.PubMed

40.

Eckel HE, Raunik W, Rogatsch H. Laryngeal intraepithelial neoplasia. [Article in German]. Laryngorhinootologie. 2008;87(6):425–38.PubMed

41.

Sakr WA, Gnepp DR, Crissman JD. Squamous intraepithelial neoplasia of the upper aerodigestive tract. In: Gnepp DR, editor. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia: Elsevier; 2009. p. 1–44.

42.

Voltaggio L, Cimino-Mathews A, Bishop JA, Argani P, Cuda JD, Epstein JI, et al. Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: a review by organ system. CA Cancer J Clin. 2016;66(5):408–36.PubMed

43.

Mai KT, Hogan K, Wasserman JK. Laryngeal squamous cell carcinomas are commonly associated with differentiated squamous Intraepithelial neoplasia with or without an admixture with usual type of squamous intraepithelial neoplasia: clinical and pathologic significance. Appl Immunohistochem Mol Morphol. 2018;26(5):351–9.PubMed

44.

Gale N, Michaels L, Luzar B, Poljak M, Zidar N, Fischinger J, et al. Current review on squamous intraepithelial lesions of the larynx. Histopathology. 2009;54(6):639–56.PubMed

45.

Gale N, Gnepp DR, Poljak M, Strojan P, Cardesa A, Helliwell T, et al. Laryngeal squamous intraepithelial lesions: an updated review on etiology, classification, molecular changes, and treatment. Adv Anat Pathol. 2016;23(2):84–91.PubMed

46.

Mehanna H, Paleri V, Robson A, Wight R, Helliwell T. Consensus statement by otorhinolaryngologists and pathologists on the diagnosis and management of laryngeal dysplasia. Clin Otolaryngol. 2010;35(3):170–6.PubMed

47.

Fusconi M, Campo F, Gallo A, Zambetti G, Martellucci S, Seccia A, et al. Laryngeal cancer, HPV DNA vs E6/E7 mRNA test: a systematic review. J Voice. 2017;31(2):248.e1–5.

48.

zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2(5):342–50.PubMed

49.

Gale N, Poljak M, Zidar N. Update from the 4th edition of the World Health Organization Classification of head and neck tumours: what is new in the 2017 WHO blue book for tumours of the hypopharynx, larynx, trachea and parapharyngeal space. Head Neck Pathol. 2017;11(1):23–32.PubMedPubMedCentral

50.

Gale N. Head and neck cancer and HPV infection. 27th European Congress of Pathology, Belgrade, 2015; Sy-24, Abstract.

51.

Zhang L, Lewis JS Jr, El-Mofty SK, Gandhi M, Chernock RD. Nonkeratinizing squamous cell carcinoma in situ of the upper aerodigestive tract: an HPV-related entity. Head Neck Pathol. 2017;11(2):152–61.PubMed

Titel: Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems—A Short Review
verfasst von: Nina Gale
Antonio Cardesa
Juan C. Hernandez-Prera
Pieter J. Slootweg
Bruce M. Wenig
Nina Zidar
Publikationsdatum: 05.03.2020
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 4/2020
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-020-01149-9

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Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems—A Short Review

Abstract

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