nach oben

Erschienen in:

01.05.2011 | Original Article

Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

verfasst von: Kazunari Ishii, Takafumi Uemura, Naokazu Miyamoto, Toshiki Yoshikawa, Toshiaki Yamaguchi, Tatsuhiko Ashihara, Yukihiro Ohtani

Erschienen in: Annals of Nuclear Medicine | Ausgabe 4/2011

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The graph plot method, a technique that uses N-isopropyl-¹²³I-p-iodoamphetamine (IMP) and single photon emission computed tomography (SPECT) for non-invasive measurement of regional cerebral blood flow (CBF), has been developed and applied in the clinical setting, although it has been performed without obtaining normal CBF values in normal, healthy subjects. The aim of this study was to measure normal regional CBF in older healthy subjects with IMP SPECT and the graph plot method.

Subjects and methods

Eleven healthy volunteers (mean age: 63.5 ± 8.9 years; six males and five females) were recruited and regional CBF was measured using IMP SPECT and the graph plot method.

Results

The averaged global CBF was 45.4 ml/100 g/min. The distribution of regional CBF was almost homogenous in the cortices. There was no significant correlation between the global CBF and age in subjects aged 50–80 years.

Conclusion

We used the IMP graph plot method to measure regional CBF in normal healthy subjects, without arterial blood sampling, and obtained compatible CBF values. This method is non-invasive and convenient for determination of regional CBF in the clinical setting.

Kuhl DE, Barrio JR, Huang SC, Selin C, Ackermann RF, Lear JL, et al. Quantifying local cerebral blood flow by N-isopropyl-p-[¹²³I] iodoamphetamine (IMP) tomography. J Nucl Med. 1982;23:196–203.PubMed

Iida H, Itoh H, Nakazawa M, Hatazawa J, Nishimura H, Onishi Y, et al. Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med. 1994;35:2019–30.PubMed

Iida H, Itoh H, Bloomfield PM, Munaka M, Higano S, Murakami M, et al. A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodoamphetamine with one blood sampling. Eur J Nucl Med. 1994;21:1072–84.PubMedCrossRef

Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. A quantitative approach to technetium-99m hexamethylpropylene amine oxime. Eur J Nucl Med. 1992;19:195–200.PubMedCrossRef

Matsuda H, Yagishita A, Tsuji S, Hisada K. A quantitative approach to technetium-99m ethyl cysteinate dimer: a comparison with technetium-99m hexamethylpropylene amine oxime. Eur J Nucl Med. 1995;22:633–7.PubMedCrossRef

Gemmell HG, Evans NT, Besson JA, Roeda D, Davidson J, Dodd MG, et al. Regional cerebral blood flow imaging: a quantitative comparison of technetium-99m-HMPAO SPECT with C¹⁵O₂ PET. J Nucl Med. 1990;31:1595–600.PubMed

Ito H, Inoue K, Goto R, Kinomura S, Taki Y, Okada K, et al. Database of normal human cerebral blood flow measured by SPECT. I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry. Ann Nucl Med. 2006;20:131–8.PubMedCrossRef

Kado H, Iida H, Kimura H, Ogawa T, Narita Y, Hatazawa J, et al. Brain perfusion SPECT study with ^99mTc-bicisate: clinical pitfalls and improved diagnostic accuracy with a combination of linearization and scatter-attenuation correction. Ann Nucl Med. 2001;15:123–9.PubMedCrossRef

Okamoto K, Ushijima Y, Okuyama C, Nakamura T, Nishimura T. Measurement of cerebral blood flow using graph plot analysis and I-123 iodoamphetamine. Clin Nucl Med. 2002;27:191–6.PubMedCrossRef

10.

Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med. 1995;36:1238–48.PubMed

11.

Minoshima S, Koeppe RA, Frey KA, Kuhl DE. Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med. 1994;35:1528–37.PubMed

12.

Hosaka K, Ishii K, Sakamoto S, Sadato N, Fukuda H, Kato T, et al. Validation of anatomical standardization of FDG PET images of normal brain: comparison of SPM and NEUROSTAT. Eur J Nucl Med Mol Imaging. 2005;32:92–7.PubMedCrossRef

13.

Hosoda K, Kawaguchi T, Ishii K, Minoshima S, Kohmura E. Comparison of conventional region of interest and statistical mapping method in brain single-photon emission computed tomography for prediction of hyperperfusion after carotid endarterectomy. Neurosurgery. 2005;57:32–41.PubMedCrossRef

14.

Nishizawa S, Shiozaki T, Ueno M, Toyoda H, Shimono T, Kamoto Y, et al. A new method to estimate rCBF using IMP and SPECT without any blood sampling. Ann Nucl Med. 2000;14:433–40.PubMedCrossRef

15.

Hatazawa J, Iida H, Shimosegawa E, Sato T, Murakami M, Miura Y. Regional cerebral blood flow measurement with iodine-123-IMP autoradiography: normal values, reproducibility and sensitivity to hypoperfusion. J Nucl Med. 1997;38:1102–8.PubMed

16.

Hatazawa J, Fujita H, Kanno I, Satoh T, Iida H, Miura S, et al. Regional cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization rate in normal volunteers measured by the autoradiographic technique and the single breath inhalation method. Ann Nucl Med. 1995;9:15–21.PubMedCrossRef

17.

Ito H, Kanno I, Kato C, Sasaki T, Ishii K, Ouchi Y, et al. Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with ¹⁵O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging. 2004;31:635–43.PubMedCrossRef

18.

Kety SS, Schmidt CF. The nitrous oxide method for the quantitative determination of cerebral blood flow in man; theory, procedure and normal values. J Clin Invest. 1948;27:476–83.CrossRef

19.

Ito H, Iida H, Kinoshita T, Hatazawa J, Okudera T, Uemura K. Effects of scatter correction on regional distribution of cerebral blood flow using I-123-IMP and SPECT. Ann Nucl Med. 1999;13:331–6.PubMedCrossRef

20.

Iida H, Narita Y, Kado H, Kashikura A, Sugawara S, Shoji Y, et al. Effects of scatter and attenuation correction on quantitative assessment of regional cerebral blood flow with SPECT. J Nucl Med. 1998;39:181–9.PubMed

21.

Ikeda H, Mariko M, Komatsu M, Takahashi K, Yasui S, Takahashi K. Prolonged lung retention of ¹²³I-IMP in pulmonary disease. Eur J Nucl Med. 1989;15:646–8.PubMedCrossRef

22.

Rourke SB, Dupont RM, Grant I, Lehr PP, Lamoureux G, Halpern S, et al. Reduction in cortical IMP-SPET tracer uptake with recent cigarette consumption in a young group of healthy males. San Diego HIV Neurobehavioral Research Center. Eur J Nucl Med. 1997;24:422–7.PubMed

23.

Ishii K, Sasaki M, Kitagaki H, Sakamoto S, Yamaji S, Maeda K. Regional difference in cerebral blood flow and oxidative metabolism in human cortex. J Nucl Med. 1996;37:1086–8.PubMed

Titel: Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT
verfasst von: Kazunari Ishii
Takafumi Uemura
Naokazu Miyamoto
Toshiki Yoshikawa
Toshiaki Yamaguchi
Tatsuhiko Ashihara
Yukihiro Ohtani
Publikationsdatum: 01.05.2011
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 4/2011
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-010-0451-1

Springer Medizin

Abstract

Purpose

Subjects and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2011

Clinical significance of CT density-based, non-uniform photon attenuation correction of deep-inspiratory breath-hold perfusion SPECT

Differential uptake of 18F-FDG in patients with synchronous lung cancers

A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma

Relationship of detection rate of PET cancer screening examinees and risk factors: analysis of background of examinees

Clinical value of FDG-PET for preoperative evaluation of endometrial cancer

Positive correlations between tumor uptake on FDG PET and energy expenditure of patients with esophageal cancer