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Erschienen in: Annals of Nuclear Medicine 10/2011

01.12.2011 | Invited review article

The molecular imaging approach to image infections and inflammation by nuclear medicine techniques

verfasst von: Alberto Signore, Andor W. J. M. Glaudemans

Erschienen in: Annals of Nuclear Medicine | Ausgabe 10/2011

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Abstract

Inflammatory and infectious diseases are a heterogeneous class of diseases that may be divided into infections, acute inflammation and chronic inflammation. Radiological imaging techniques have, with the exception of functional MRI, high sensitivity but lack in specificity. Nuclear medicine techniques, by contrast, allow the in vivo detection in humans of different physiologic and pathologic phenomena and offer noninvasive tools to detect early pathophysiological changes before anatomical changes occur. In this review, we highlight the role of nuclear medicine in inflammation/infection with emphasis on molecular imaging for in vivo histological characterization of affected tissues for diagnostic purposes and follow-up of therapies. We also describe the clinical indications of all available radiopharmaceuticals in the light of the newly available guidelines.
Literatur
1.
Zurück zum Zitat de Vries EF, Roca M, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:842–8.PubMedCrossRef de Vries EF, Roca M, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:842–8.PubMedCrossRef
2.
Zurück zum Zitat Roca M, de Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:835–41.PubMedCrossRef Roca M, de Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:835–41.PubMedCrossRef
3.
Zurück zum Zitat Love C, Palestro CJ. Radionuclide imaging of infection. J Nucl Med Technol. 2004;32:47–57.PubMed Love C, Palestro CJ. Radionuclide imaging of infection. J Nucl Med Technol. 2004;32:47–57.PubMed
4.
Zurück zum Zitat Bekerman C, Hoffer PB, Bitran JD. The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med. 1984;14:296–323.PubMedCrossRef Bekerman C, Hoffer PB, Bitran JD. The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med. 1984;14:296–323.PubMedCrossRef
5.
Zurück zum Zitat Perkins PJ. Early gallium-67 abdominal imaging: pitfalls due to bowel activity. AJR Am J Roentgenol. 1981;136:1016–7.PubMed Perkins PJ. Early gallium-67 abdominal imaging: pitfalls due to bowel activity. AJR Am J Roentgenol. 1981;136:1016–7.PubMed
6.
Zurück zum Zitat Rizzello A, Di Pierro D, Lodi F, Trespidi S, Cicoria G, Pancaldi D, et al. Synthesis and quality control of 68 Ga citrate for routine clinical PET. Nucl Med Commun. 2009;30:542–5.PubMedCrossRef Rizzello A, Di Pierro D, Lodi F, Trespidi S, Cicoria G, Pancaldi D, et al. Synthesis and quality control of 68 Ga citrate for routine clinical PET. Nucl Med Commun. 2009;30:542–5.PubMedCrossRef
7.
Zurück zum Zitat Datz FL. Indium-111-labeled leukocytes for the detection of infection: current status. Semin Nucl Med. 1994;24:92–109.PubMedCrossRef Datz FL. Indium-111-labeled leukocytes for the detection of infection: current status. Semin Nucl Med. 1994;24:92–109.PubMedCrossRef
8.
Zurück zum Zitat Papos M, Nagy F, Narai G, Rajtar M, Szantai G, Lang J, et al. Anti-granulocyte immunoscintigraphy and [99mTc]hexamethylpropyleneamine-oxime-labeled leukocyte scintigraphy in inflammatory bowel disease. Dig Dis Sci. 1996;41:412–20.PubMedCrossRef Papos M, Nagy F, Narai G, Rajtar M, Szantai G, Lang J, et al. Anti-granulocyte immunoscintigraphy and [99mTc]hexamethylpropyleneamine-oxime-labeled leukocyte scintigraphy in inflammatory bowel disease. Dig Dis Sci. 1996;41:412–20.PubMedCrossRef
9.
Zurück zum Zitat Signore A, Mather SJ, Piaggio G, Malviya G, Dierckx RA. Molecular imaging of inflammation/infection: nuclear medicine and optical imaging agents and methods. Chem Rev. 2010;110:3112–45.PubMedCrossRef Signore A, Mather SJ, Piaggio G, Malviya G, Dierckx RA. Molecular imaging of inflammation/infection: nuclear medicine and optical imaging agents and methods. Chem Rev. 2010;110:3112–45.PubMedCrossRef
10.
Zurück zum Zitat Liberatore M, Clemente M, Iurilli AP, Zorzin L, Marini M, Dirocco E, et al. Scintigraphic evaluation of disease-activity in rheumatoid-arthritis—a comparison of Tc-99M human nonspecific immunoglobulins, leukocytes and albumin nanocolloids. Eur J Nucl Med. 1992;19:853–7.PubMedCrossRef Liberatore M, Clemente M, Iurilli AP, Zorzin L, Marini M, Dirocco E, et al. Scintigraphic evaluation of disease-activity in rheumatoid-arthritis—a comparison of Tc-99M human nonspecific immunoglobulins, leukocytes and albumin nanocolloids. Eur J Nucl Med. 1992;19:853–7.PubMedCrossRef
11.
Zurück zum Zitat van der Laken CJ, Boerman OC, Oyen WJG, Laverman P, van de Ven MTP, Corstens FHM, et al. In vivo expression of interleukin-1 receptors during various experimentally induced inflammatory conditions. J Infect Dis. 1998;177:1398–401.PubMedCrossRef van der Laken CJ, Boerman OC, Oyen WJG, Laverman P, van de Ven MTP, Corstens FHM, et al. In vivo expression of interleukin-1 receptors during various experimentally induced inflammatory conditions. J Infect Dis. 1998;177:1398–401.PubMedCrossRef
12.
Zurück zum Zitat Barrera P, van der Laken CJ, Oven WJG, van de Putte LBA, Corstens FHM. Radiolabeled IL-1ra for detection of synovitis in patients with RA Preliminary results. Arthritis Rheum. 1998;41:S37. Barrera P, van der Laken CJ, Oven WJG, van de Putte LBA, Corstens FHM. Radiolabeled IL-1ra for detection of synovitis in patients with RA Preliminary results. Arthritis Rheum. 1998;41:S37.
13.
Zurück zum Zitat van der Laken CJ, Boerman OC, Oyen WJG, van de Ven MTP, van der Meer JWM, Corstens FHM. Imaging of infection in rabbits with radioiodinated interleukin-1 (alpha and beta), its receptor antagonist and a chemotactic peptide: a comparative study. Eur J Nucl Med. 1998;25:347–52.PubMedCrossRef van der Laken CJ, Boerman OC, Oyen WJG, van de Ven MTP, van der Meer JWM, Corstens FHM. Imaging of infection in rabbits with radioiodinated interleukin-1 (alpha and beta), its receptor antagonist and a chemotactic peptide: a comparative study. Eur J Nucl Med. 1998;25:347–52.PubMedCrossRef
14.
Zurück zum Zitat Gratz S, Rennen H, Boerman O, Oyen W, Corstens F. Rapid imaging of experimental colitis with 99mTc-interleukin-8 in rabbits. Eur J Nucl Med. 2001;28:1044. Gratz S, Rennen H, Boerman O, Oyen W, Corstens F. Rapid imaging of experimental colitis with 99mTc-interleukin-8 in rabbits. Eur J Nucl Med. 2001;28:1044.
15.
Zurück zum Zitat Gratz S, Rennen HJJM, Boerman OC, Oyen WJG, Burma P, Corstens FHM. Tc-99m-interleukin-8 for imaging acute osteomyelitis. J Nucl Med. 2001;42:1257–64.PubMed Gratz S, Rennen HJJM, Boerman OC, Oyen WJG, Burma P, Corstens FHM. Tc-99m-interleukin-8 for imaging acute osteomyelitis. J Nucl Med. 2001;42:1257–64.PubMed
16.
Zurück zum Zitat Rennen HJ, Boerman OC, Frielink C, Oyen WJ, Corstens FH. Kinetics of Tc-99m-labeled interleukin-8 in inflammation and infection. J Nucl Med. 2003;44:153P. Rennen HJ, Boerman OC, Frielink C, Oyen WJ, Corstens FH. Kinetics of Tc-99m-labeled interleukin-8 in inflammation and infection. J Nucl Med. 2003;44:153P.
17.
Zurück zum Zitat Chianelli M, Boerman OC, Malviya G, Galli F, Oyen WJG, Signore A. Receptor binding ligands to image infection. Curr Pharm Des. 2008;14:3316–25.PubMedCrossRef Chianelli M, Boerman OC, Malviya G, Galli F, Oyen WJG, Signore A. Receptor binding ligands to image infection. Curr Pharm Des. 2008;14:3316–25.PubMedCrossRef
18.
Zurück zum Zitat Melendez-Alafort L, Rodriguez-Cortes J, Ferro-Flores G, de Murphy CA, Herrera-Rodriguez R, Mitsoura E, et al. Biokinetics of Tc-99m-UBI 29–41 in humans. Nucl Med Biol. 2004;31:373–9.PubMedCrossRef Melendez-Alafort L, Rodriguez-Cortes J, Ferro-Flores G, de Murphy CA, Herrera-Rodriguez R, Mitsoura E, et al. Biokinetics of Tc-99m-UBI 29–41 in humans. Nucl Med Biol. 2004;31:373–9.PubMedCrossRef
19.
Zurück zum Zitat Welling MM, Nibbering PH, Paulusma-Annema A, Hiemstra PS, Pauwels EKJ, Calame W. Imaging of bacterial infections with Tc-99m-labeled human neutrophil peptide-1. J Nucl Med. 1999;40:2073–80.PubMed Welling MM, Nibbering PH, Paulusma-Annema A, Hiemstra PS, Pauwels EKJ, Calame W. Imaging of bacterial infections with Tc-99m-labeled human neutrophil peptide-1. J Nucl Med. 1999;40:2073–80.PubMed
20.
Zurück zum Zitat Welling MM, Paulusma-Annema A, Balter HS, Pauwels EKJ, Nibbering PH. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 2000;27:292–301.PubMedCrossRef Welling MM, Paulusma-Annema A, Balter HS, Pauwels EKJ, Nibbering PH. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 2000;27:292–301.PubMedCrossRef
21.
Zurück zum Zitat Rusckowski M, Gupta S, Liu GZ, Dou SP, Hnatowich DJ. Investigation of four Tc-99m-labeled bacteriophages for infection-specific imaging. Nucl Med Biol. 2008;35:433–40.PubMedCrossRef Rusckowski M, Gupta S, Liu GZ, Dou SP, Hnatowich DJ. Investigation of four Tc-99m-labeled bacteriophages for infection-specific imaging. Nucl Med Biol. 2008;35:433–40.PubMedCrossRef
22.
Zurück zum Zitat Rusckowski M, Fritz B, Hnatowich DJ. Localization of infection using streptavidin and biotin—an alternative to nonspecific polyclonal immunoglobulin. J Nucl Med. 1992;33:1810–5.PubMed Rusckowski M, Fritz B, Hnatowich DJ. Localization of infection using streptavidin and biotin—an alternative to nonspecific polyclonal immunoglobulin. J Nucl Med. 1992;33:1810–5.PubMed
23.
Zurück zum Zitat Lambrecht FY. Evaluation of Tc-99m-labeled antibiotics for infection detection. Ann Nucl Med. 2011;25:1–6.PubMedCrossRef Lambrecht FY. Evaluation of Tc-99m-labeled antibiotics for infection detection. Ann Nucl Med. 2011;25:1–6.PubMedCrossRef
24.
Zurück zum Zitat Britton KE, Wareham DW, Das SS, Solanki KK, Amaral H, Bhatnagar A, et al. Imaging bacterial infection with Tc-99m-ciprofloxacin (Infecton). J Clin Pathol. 2002;55:817–23.PubMedCrossRef Britton KE, Wareham DW, Das SS, Solanki KK, Amaral H, Bhatnagar A, et al. Imaging bacterial infection with Tc-99m-ciprofloxacin (Infecton). J Clin Pathol. 2002;55:817–23.PubMedCrossRef
25.
Zurück zum Zitat Solanki KK, Das SS, Britton KE. Infection is not specific for bacterial osteo-articular infective pathology. Eur J Nucl Med Mol Imaging. 2003;30:181–2.PubMedCrossRef Solanki KK, Das SS, Britton KE. Infection is not specific for bacterial osteo-articular infective pathology. Eur J Nucl Med Mol Imaging. 2003;30:181–2.PubMedCrossRef
26.
Zurück zum Zitat Lupetti A, Welling MM, Mazzi U, Nibbering PH, Pauwels EKJ. Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections. Eur J Nucl Med Mol Imaging. 2002;29:674–9.PubMedCrossRef Lupetti A, Welling MM, Mazzi U, Nibbering PH, Pauwels EKJ. Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections. Eur J Nucl Med Mol Imaging. 2002;29:674–9.PubMedCrossRef
27.
28.
Zurück zum Zitat Thakur ML, Mcafee JG. The significance of chromosomal-aberrations in indium-111-labeled lymphocytes. J Nucl Med. 1984;25:922–7.PubMed Thakur ML, Mcafee JG. The significance of chromosomal-aberrations in indium-111-labeled lymphocytes. J Nucl Med. 1984;25:922–7.PubMed
29.
Zurück zum Zitat Forstrom LA, Dunn WL, Mullan BP, Hung JC, Lowe VJ, Thorson LM. Biodistribution and dosimetry of [F-18]fluorodeoxyglucose labelled leukocytes in normal human subjects. Nucl Med Commun. 2002;23:721–5.PubMedCrossRef Forstrom LA, Dunn WL, Mullan BP, Hung JC, Lowe VJ, Thorson LM. Biodistribution and dosimetry of [F-18]fluorodeoxyglucose labelled leukocytes in normal human subjects. Nucl Med Commun. 2002;23:721–5.PubMedCrossRef
30.
Zurück zum Zitat Palestro CJ, Love C, Miller TT. Diagnostic imaging tests and microbial infections. Cellular Microbiology. 2007;9:2323–33.PubMedCrossRef Palestro CJ, Love C, Miller TT. Diagnostic imaging tests and microbial infections. Cellular Microbiology. 2007;9:2323–33.PubMedCrossRef
31.
Zurück zum Zitat Rennen HJJM, Boerman OC, Oyen WJG, Corstens FHM. Imaging infection/inflammation in the new millennium. Eur J Nucl Med. 2001;28:241–52.PubMedCrossRef Rennen HJJM, Boerman OC, Oyen WJG, Corstens FHM. Imaging infection/inflammation in the new millennium. Eur J Nucl Med. 2001;28:241–52.PubMedCrossRef
32.
Zurück zum Zitat Skehan SJ, White JF, Evans JW, Parry-Jones DR, Solanki CK, Ballinger JR, et al. Mechanism of accumulation of Tc-99m-sulesomab in inflammation. J Nucl Med. 2003;44:11–8.PubMed Skehan SJ, White JF, Evans JW, Parry-Jones DR, Solanki CK, Ballinger JR, et al. Mechanism of accumulation of Tc-99m-sulesomab in inflammation. J Nucl Med. 2003;44:11–8.PubMed
33.
Zurück zum Zitat Bleeker-Rovers CP, Vos FJ, Corstens FHM, Oyen WJG. Imaging of infectious diseases using [F-18]fluorodeoxyglucose PET. Q J Nucl Med Mol Imaging. 2008;52:17–29.PubMed Bleeker-Rovers CP, Vos FJ, Corstens FHM, Oyen WJG. Imaging of infectious diseases using [F-18]fluorodeoxyglucose PET. Q J Nucl Med Mol Imaging. 2008;52:17–29.PubMed
34.
Zurück zum Zitat Larikka MJ, Ahonen AK, Junila JA, Niemela O, Hamalainen MM, Syrjala HP. Extended combined Tc-99m-white blood cell and bone imaging improves the diagnostic accuracy in the detection of hip replacement infections. Eur J Nucl Med. 2001;28:288–93.PubMedCrossRef Larikka MJ, Ahonen AK, Junila JA, Niemela O, Hamalainen MM, Syrjala HP. Extended combined Tc-99m-white blood cell and bone imaging improves the diagnostic accuracy in the detection of hip replacement infections. Eur J Nucl Med. 2001;28:288–93.PubMedCrossRef
35.
Zurück zum Zitat Liberatore M, Iurilli AP, Ponzo F, Prosperi D, Santini C, Baiocchi P, et al. Clinical usefulness of technetium-99m-HMPAO-labeled leukocyte scan in prosthetic vascular graft infection. J Nucl Med. 1998;39:875–9.PubMed Liberatore M, Iurilli AP, Ponzo F, Prosperi D, Santini C, Baiocchi P, et al. Clinical usefulness of technetium-99m-HMPAO-labeled leukocyte scan in prosthetic vascular graft infection. J Nucl Med. 1998;39:875–9.PubMed
36.
Zurück zum Zitat Peters AM. The utility of [Tc-99M] HMPAO-leukocytes for imaging infection. Semin Nucl Med. 1994;24:110–27.PubMedCrossRef Peters AM. The utility of [Tc-99M] HMPAO-leukocytes for imaging infection. Semin Nucl Med. 1994;24:110–27.PubMedCrossRef
37.
Zurück zum Zitat Castaigne C, Tondeur M, De Wit S, Hildebrand M, Clumeck N, Dusart M. Clinical value of FDG-PET/CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective study. Nucl Med Commun. 2009;30:41–7.PubMedCrossRef Castaigne C, Tondeur M, De Wit S, Hildebrand M, Clumeck N, Dusart M. Clinical value of FDG-PET/CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective study. Nucl Med Commun. 2009;30:41–7.PubMedCrossRef
38.
Zurück zum Zitat Glaudemans AW, Signore A. FDG-PET/CT in infections: the imaging method of choice? Eur J Nucl Med Mol Imaging. 2010;37:1986–91.PubMedCrossRef Glaudemans AW, Signore A. FDG-PET/CT in infections: the imaging method of choice? Eur J Nucl Med Mol Imaging. 2010;37:1986–91.PubMedCrossRef
39.
Zurück zum Zitat Glaudemans AWJM, Maccioni F, Mansi L, Dierckx RAJO, Signore A. Imaging of cell trafficking in Crohn’s disease. J Cell Physiol. 2010;223:562–71.PubMed Glaudemans AWJM, Maccioni F, Mansi L, Dierckx RAJO, Signore A. Imaging of cell trafficking in Crohn’s disease. J Cell Physiol. 2010;223:562–71.PubMed
40.
Zurück zum Zitat Palestro CJ, Love C, Bhargava KK. Labeled leukocyte imaging: current status and future directions. Q J Nucl Med Mol Imaging. 2009;53:105–23.PubMed Palestro CJ, Love C, Bhargava KK. Labeled leukocyte imaging: current status and future directions. Q J Nucl Med Mol Imaging. 2009;53:105–23.PubMed
41.
Zurück zum Zitat van der Bruggen W, Bleeker-Rovers CP, Boerman OC, Gotthardt M, Oyen WJG. PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 2010;40:3–15.PubMedCrossRef van der Bruggen W, Bleeker-Rovers CP, Boerman OC, Gotthardt M, Oyen WJG. PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 2010;40:3–15.PubMedCrossRef
42.
Zurück zum Zitat Love C, Marwin SE, Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med. 2009;39:66–78.PubMedCrossRef Love C, Marwin SE, Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med. 2009;39:66–78.PubMedCrossRef
43.
Zurück zum Zitat Cerqueira MD, Jacobson AF, Matsuda M, Stratton JR. In-111 leukocyte scintigraphic detection of mitral-valve vegetations in active bacterial-endocarditis. Am J Cardiol. 1989;64:1080–1.PubMedCrossRef Cerqueira MD, Jacobson AF, Matsuda M, Stratton JR. In-111 leukocyte scintigraphic detection of mitral-valve vegetations in active bacterial-endocarditis. Am J Cardiol. 1989;64:1080–1.PubMedCrossRef
44.
Zurück zum Zitat Morguet AJ, Munz DL, Ivancevic V, Werner GS, Sandrock D, Bokemeier M, et al. Immunoscintigraphy using Tc-99M-labeled anti-NCA-95 antigranulocyte antibodies as an adjunct to echocardiography in subacute infective endocarditis. J Am Coll Cardiol. 1994;23:1171–8.PubMedCrossRef Morguet AJ, Munz DL, Ivancevic V, Werner GS, Sandrock D, Bokemeier M, et al. Immunoscintigraphy using Tc-99M-labeled anti-NCA-95 antigranulocyte antibodies as an adjunct to echocardiography in subacute infective endocarditis. J Am Coll Cardiol. 1994;23:1171–8.PubMedCrossRef
45.
Zurück zum Zitat Peltier P, Potel G, Lovat E, Baron D, Chatal JF. Detection of lung and bone infection with antigranulocyte monoclonal-antibody BW-250/183 radiolabeled with Tc(M)-99. Nucl Med Commun. 1993;14:766–74.PubMedCrossRef Peltier P, Potel G, Lovat E, Baron D, Chatal JF. Detection of lung and bone infection with antigranulocyte monoclonal-antibody BW-250/183 radiolabeled with Tc(M)-99. Nucl Med Commun. 1993;14:766–74.PubMedCrossRef
46.
Zurück zum Zitat Dominguezgadea L, Martincurto LM, Delacalle H, Crespo A. Diabetic foot infections - scintigraphic evaluation with Tc-99(M)-labeled antigranulocyte antibodies. Nucl Med Commun. 1993;14:212–8.CrossRef Dominguezgadea L, Martincurto LM, Delacalle H, Crespo A. Diabetic foot infections - scintigraphic evaluation with Tc-99(M)-labeled antigranulocyte antibodies. Nucl Med Commun. 1993;14:212–8.CrossRef
47.
Zurück zum Zitat Boubaker A, Delaloye AB, Blanc CH, Dutoit M, Leyvraz PF, Delaloye B. Immunoscintigraphy with antigranulocyte monoclonal-antibodies for the diagnosis of septic loosening of hip prostheses. Eur J Nucl Med. 1995;22:139–47.PubMedCrossRef Boubaker A, Delaloye AB, Blanc CH, Dutoit M, Leyvraz PF, Delaloye B. Immunoscintigraphy with antigranulocyte monoclonal-antibodies for the diagnosis of septic loosening of hip prostheses. Eur J Nucl Med. 1995;22:139–47.PubMedCrossRef
48.
Zurück zum Zitat Klett R, Kordelle J, Stahl U, Khalisi A, Puille M, Steiner D, et al. Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183. Eur J Nucl Med Mol Imaging. 2003;30:1463–6.PubMedCrossRef Klett R, Kordelle J, Stahl U, Khalisi A, Puille M, Steiner D, et al. Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183. Eur J Nucl Med Mol Imaging. 2003;30:1463–6.PubMedCrossRef
49.
Zurück zum Zitat Scheidler J, Leinsinger G, Pfahler M, Kirsch CM. Diagnosis of osteomyelitis—accuracy and limitations of antigranulocyte antibody imaging compared to 3-phase bone-scan. Clin Nucl Med. 1994;19:731–7.PubMedCrossRef Scheidler J, Leinsinger G, Pfahler M, Kirsch CM. Diagnosis of osteomyelitis—accuracy and limitations of antigranulocyte antibody imaging compared to 3-phase bone-scan. Clin Nucl Med. 1994;19:731–7.PubMedCrossRef
50.
Zurück zum Zitat Gratz S, Braun HG, Behr TM, Meller J, Herrmann A, Conrad M, et al. Photopenia in chronic vertebral osteomyelitis with Tc-99m antigranulocyte antibody (BW 250/183). J Nucl Med. 1997;38:494. Gratz S, Braun HG, Behr TM, Meller J, Herrmann A, Conrad M, et al. Photopenia in chronic vertebral osteomyelitis with Tc-99m antigranulocyte antibody (BW 250/183). J Nucl Med. 1997;38:494.
51.
Zurück zum Zitat Gyorke T, Duffek L, Bartfai K, Mako E, Karlinger K, Mester A, et al. The role of nuclear medicine in inflammatory bowel disease. A review with experiences of aspecific bowel activity using immunoscintigraphy with Tc-99m anti-granulocyte antibodies. Eur J Radiol. 2000;35:183–92.PubMedCrossRef Gyorke T, Duffek L, Bartfai K, Mako E, Karlinger K, Mester A, et al. The role of nuclear medicine in inflammatory bowel disease. A review with experiences of aspecific bowel activity using immunoscintigraphy with Tc-99m anti-granulocyte antibodies. Eur J Radiol. 2000;35:183–92.PubMedCrossRef
52.
Zurück zum Zitat Mahida YR, Perkins AC, Frier M, Wastie ML, Hawkey CJ. Monoclonal antigranulocyte antibody imaging in inflammatory bowel-disease—a preliminary report. Nucl Med Commun. 1992;13:330–5.PubMedCrossRef Mahida YR, Perkins AC, Frier M, Wastie ML, Hawkey CJ. Monoclonal antigranulocyte antibody imaging in inflammatory bowel-disease—a preliminary report. Nucl Med Commun. 1992;13:330–5.PubMedCrossRef
53.
Zurück zum Zitat Becker W, Dolkemeyer U, Gramatzki M, Schneider MU, Scheele J, Wolf F. Use of immunoscintigraphy in the diagnosis of fever of unknown origin. Eur J Nucl Med. 1993;20:1078–83.PubMedCrossRef Becker W, Dolkemeyer U, Gramatzki M, Schneider MU, Scheele J, Wolf F. Use of immunoscintigraphy in the diagnosis of fever of unknown origin. Eur J Nucl Med. 1993;20:1078–83.PubMedCrossRef
54.
Zurück zum Zitat Meller J, Ivancevic V, Conrad M, Gratz S, Munz DL, Becker W. Clinical value of immunoscintigraphy in patients with fever of unknown origin. J Nucl Med. 1998;39:1248–53.PubMed Meller J, Ivancevic V, Conrad M, Gratz S, Munz DL, Becker W. Clinical value of immunoscintigraphy in patients with fever of unknown origin. J Nucl Med. 1998;39:1248–53.PubMed
55.
Zurück zum Zitat Gratz S, Behr TM, Herrmann A, Meller J, Conrad M, Zappel H, et al. Immunoscintigraphy (BW 250/183) in neonates and infants with fever of unknown origin. Nucl Med Commun. 1998;19:1037–45.PubMedCrossRef Gratz S, Behr TM, Herrmann A, Meller J, Conrad M, Zappel H, et al. Immunoscintigraphy (BW 250/183) in neonates and infants with fever of unknown origin. Nucl Med Commun. 1998;19:1037–45.PubMedCrossRef
56.
Zurück zum Zitat Gratz S, Behr T, Herrmann A, Dresing K, Tarditi L, Franceschini R, et al. Intraindividual comparison of Tc-99m-labelled anti-SSEA-1 antigranulocyte antibody and Tc-99m-HMPAO labelled white blood cells for the imaging of infection. Eur J Nucl Med. 1998;25:386–93.PubMedCrossRef Gratz S, Behr T, Herrmann A, Dresing K, Tarditi L, Franceschini R, et al. Intraindividual comparison of Tc-99m-labelled anti-SSEA-1 antigranulocyte antibody and Tc-99m-HMPAO labelled white blood cells for the imaging of infection. Eur J Nucl Med. 1998;25:386–93.PubMedCrossRef
57.
Zurück zum Zitat Thakur ML, Marcus CS, Henneman P, Butler J, Sinow R, Diggles L, et al. Imaging inflammatory diseases with neutrophil-specific technetium-99m-labeled monoclonal antibody anti-SSEA-1. J Nucl Med. 1996;37:1789–95.PubMed Thakur ML, Marcus CS, Henneman P, Butler J, Sinow R, Diggles L, et al. Imaging inflammatory diseases with neutrophil-specific technetium-99m-labeled monoclonal antibody anti-SSEA-1. J Nucl Med. 1996;37:1789–95.PubMed
58.
Zurück zum Zitat Thakur ML, Marcus CS, Kipper SL, Ahdoot R, Diggles L, Pham HL, et al. Imaging infection with LeuTech (R). Nucl Med Commun. 2001;22:513–9.PubMedCrossRef Thakur ML, Marcus CS, Kipper SL, Ahdoot R, Diggles L, Pham HL, et al. Imaging infection with LeuTech (R). Nucl Med Commun. 2001;22:513–9.PubMedCrossRef
59.
Zurück zum Zitat Rypins EB, Kipper SL. Scintigraphic determination of equivocal appendicitis. Am Surg. 2000;66:891–5.PubMed Rypins EB, Kipper SL. Scintigraphic determination of equivocal appendicitis. Am Surg. 2000;66:891–5.PubMed
60.
Zurück zum Zitat Becker W, Bair J, Behr T, Repp R, Streckenbach H, Beck H, et al. Detection of soft-tissue infections and osteomyelitis using a Tc-99M-labeled antigranulocyte monoclonal-antibody fragment. J Nucl Med. 1994;35:1436–43.PubMed Becker W, Bair J, Behr T, Repp R, Streckenbach H, Beck H, et al. Detection of soft-tissue infections and osteomyelitis using a Tc-99M-labeled antigranulocyte monoclonal-antibody fragment. J Nucl Med. 1994;35:1436–43.PubMed
61.
Zurück zum Zitat Becker W, Palestro CJ, Winship J, Feld T, Pinsky CM, Wolf F, et al. Rapid imaging of infections with a monoclonal antibody fragment. Clin Orthopaed Relat Res. 1996;(329):263–72.CrossRef Becker W, Palestro CJ, Winship J, Feld T, Pinsky CM, Wolf F, et al. Rapid imaging of infections with a monoclonal antibody fragment. Clin Orthopaed Relat Res. 1996;(329):263–72.CrossRef
62.
Zurück zum Zitat Devillers A, Garin E, Polard JL, Poirier JY, Arvieux C, Girault S, et al. Comparison of Tc-99m-labelled antileukocyte fragment Fab’ and Tc-99m-HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections: a prospective study. Nucl Med Commun. 2000;21:747–53.PubMedCrossRef Devillers A, Garin E, Polard JL, Poirier JY, Arvieux C, Girault S, et al. Comparison of Tc-99m-labelled antileukocyte fragment Fab’ and Tc-99m-HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections: a prospective study. Nucl Med Commun. 2000;21:747–53.PubMedCrossRef
63.
Zurück zum Zitat Gratz S, Schipper ML, Dorner J, Hoffken H, Becker W, Kaiser JW, et al. LeukoScan for imaging infection in different clinical settings—a retrospective evaluation and extended review of the literature. Clin Nucl Med. 2003;28:267–76.PubMed Gratz S, Schipper ML, Dorner J, Hoffken H, Becker W, Kaiser JW, et al. LeukoScan for imaging infection in different clinical settings—a retrospective evaluation and extended review of the literature. Clin Nucl Med. 2003;28:267–76.PubMed
64.
Zurück zum Zitat Harwood SJ, Valdivia S, Hung GL, Quenzer RW. Use of sulesomab, a radiolabeled antibody fragment, to detect osteomyelitis in diabetic patients with foot ulcers by leukoscintigraphy. Clin Infect Dis. 1999;28:1200–5.PubMedCrossRef Harwood SJ, Valdivia S, Hung GL, Quenzer RW. Use of sulesomab, a radiolabeled antibody fragment, to detect osteomyelitis in diabetic patients with foot ulcers by leukoscintigraphy. Clin Infect Dis. 1999;28:1200–5.PubMedCrossRef
65.
Zurück zum Zitat Barron B, Hanna C, Passalaqua AM, Lamki L, Wegener WA, Goldenberg DM. Rapid diagnostic imaging of acute, nonclassic appendicitis by leukoscintigraphy with sulesomab, a technetium 99m-labeled antigranulocyte antibody Fab’ fragment. Surgery. 1999;125:288–96.PubMedCrossRef Barron B, Hanna C, Passalaqua AM, Lamki L, Wegener WA, Goldenberg DM. Rapid diagnostic imaging of acute, nonclassic appendicitis by leukoscintigraphy with sulesomab, a technetium 99m-labeled antigranulocyte antibody Fab’ fragment. Surgery. 1999;125:288–96.PubMedCrossRef
66.
Zurück zum Zitat Gratz S, Raddatz D, Hagenah G, Behr T, Behe M, Becker W. (TC)-T-99m-labelled antigranulocyte monoclonal antibody FAB’ fragments versus echocardiography in the diagnosis of subacute infective endocarditis. Int J Cardiol. 2000;75:75–84.PubMedCrossRef Gratz S, Raddatz D, Hagenah G, Behr T, Behe M, Becker W. (TC)-T-99m-labelled antigranulocyte monoclonal antibody FAB’ fragments versus echocardiography in the diagnosis of subacute infective endocarditis. Int J Cardiol. 2000;75:75–84.PubMedCrossRef
67.
Zurück zum Zitat Stokkel MPM, Reigman HIE, Pauwels EKJ. Scintigraphic head-to-head comparison between Tc-99m-WBCs and Tc-99m-LeukoScan in the evaluation of inflammatory bowel disease: a pilot study. Eur J Nucl Med Mol Imaging. 2002;29:251–4.PubMedCrossRef Stokkel MPM, Reigman HIE, Pauwels EKJ. Scintigraphic head-to-head comparison between Tc-99m-WBCs and Tc-99m-LeukoScan in the evaluation of inflammatory bowel disease: a pilot study. Eur J Nucl Med Mol Imaging. 2002;29:251–4.PubMedCrossRef
68.
Zurück zum Zitat Basu S, Chryssikos T, Moghadam-Kia S, Zhuang HM, Torigian DA, Alavi A. Positron emission tomography as a diagnostic tool in infection: present role and future possibilities. Semin Nucl Med. 2009;39:36–51.PubMedCrossRef Basu S, Chryssikos T, Moghadam-Kia S, Zhuang HM, Torigian DA, Alavi A. Positron emission tomography as a diagnostic tool in infection: present role and future possibilities. Semin Nucl Med. 2009;39:36–51.PubMedCrossRef
69.
Zurück zum Zitat Bleeker-Rovers CP, de Kleijn EMHA, Corstens FHM, van der Meer JWM, Oyen WJG. Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. Eur J Nucl Med Mol Imaging. 2004;31:29–37.PubMedCrossRef Bleeker-Rovers CP, de Kleijn EMHA, Corstens FHM, van der Meer JWM, Oyen WJG. Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. Eur J Nucl Med Mol Imaging. 2004;31:29–37.PubMedCrossRef
70.
Zurück zum Zitat Jasper N, Dabritz J, Frosch M, Loeffler M, Weckesser M, Foell D. Diagnostic value of [(18)F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation. Eur J Nucl Med Mol Imaging. 2010;37:136–45.PubMedCrossRef Jasper N, Dabritz J, Frosch M, Loeffler M, Weckesser M, Foell D. Diagnostic value of [(18)F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation. Eur J Nucl Med Mol Imaging. 2010;37:136–45.PubMedCrossRef
71.
Zurück zum Zitat Simons KS, Pickkers P, Bleeker-Rovers CP, Oyen WJ, van der Hoeven JG. F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection. Intensive Care Med. 2010;36:504–11.PubMedCrossRef Simons KS, Pickkers P, Bleeker-Rovers CP, Oyen WJ, van der Hoeven JG. F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection. Intensive Care Med. 2010;36:504–11.PubMedCrossRef
72.
Zurück zum Zitat Basu S, Zhuang HM, Torigian DA, Rosenbaum J, Chen WG, Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med. 2009;39:124–45.PubMedCrossRef Basu S, Zhuang HM, Torigian DA, Rosenbaum J, Chen WG, Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med. 2009;39:124–45.PubMedCrossRef
73.
Zurück zum Zitat Loffler M, Weckesser M, Franzius C, Schober O, Zimmer KP. High diagnostic value of F-18-FDG-PET in pediatric patients with chronic inflammatory bowel disease. Ann N Y Acad Sci. 2006;1072:379–85.PubMedCrossRef Loffler M, Weckesser M, Franzius C, Schober O, Zimmer KP. High diagnostic value of F-18-FDG-PET in pediatric patients with chronic inflammatory bowel disease. Ann N Y Acad Sci. 2006;1072:379–85.PubMedCrossRef
74.
Zurück zum Zitat Ito K, Kubota K, Morooka M, Hasuo K, Kuroki H, Mimori A. Clinical impact of F-18-FDG PET/CT on the management and diagnosis of infectious spondylitis. Nucl Med Commun. 2010;31:691–8.PubMedCrossRef Ito K, Kubota K, Morooka M, Hasuo K, Kuroki H, Mimori A. Clinical impact of F-18-FDG PET/CT on the management and diagnosis of infectious spondylitis. Nucl Med Commun. 2010;31:691–8.PubMedCrossRef
75.
Zurück zum Zitat Keidar Z, Nitecki S. FDG-PET for the detection of infected vascular grafts. Q J Nucl Med Mol Imaging. 2009;53:35–40.PubMed Keidar Z, Nitecki S. FDG-PET for the detection of infected vascular grafts. Q J Nucl Med Mol Imaging. 2009;53:35–40.PubMed
76.
Zurück zum Zitat Zerizer I, Tan K, Khan S, Barwick T, Marzola MC, Rubello D, et al. Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis. Eur J Radiol. 2010;73:504–9.PubMedCrossRef Zerizer I, Tan K, Khan S, Barwick T, Marzola MC, Rubello D, et al. Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis. Eur J Radiol. 2010;73:504–9.PubMedCrossRef
77.
Zurück zum Zitat Reuter S, Schirrmeister H, Kratzer W, Dreweck C, Reske SN, Kern P. Pericystic metabolic activity in alveolar echinococcosis: Assessment and follow-up by positron emission tomography. Clin Infect Dis. 1999;29:1157–63.PubMedCrossRef Reuter S, Schirrmeister H, Kratzer W, Dreweck C, Reske SN, Kern P. Pericystic metabolic activity in alveolar echinococcosis: Assessment and follow-up by positron emission tomography. Clin Infect Dis. 1999;29:1157–63.PubMedCrossRef
78.
Zurück zum Zitat Bleeker-Rovers CP, de Sevaux RGL, van Hamersvelt HW, Corstens FHM, Oyen WJG. Diagnosis of renal and hepatic cyst infections by 18-F-fluorodeoxyglucose positron emission tomography in autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2003;41:E18–21.PubMedCrossRef Bleeker-Rovers CP, de Sevaux RGL, van Hamersvelt HW, Corstens FHM, Oyen WJG. Diagnosis of renal and hepatic cyst infections by 18-F-fluorodeoxyglucose positron emission tomography in autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2003;41:E18–21.PubMedCrossRef
79.
Zurück zum Zitat ODoherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med. 1997;38:1575–83. ODoherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med. 1997;38:1575–83.
80.
Zurück zum Zitat Palestro CJ. The current role of gallium imaging in infection. Semin Nucl Med. 1994;24:128–41.PubMedCrossRef Palestro CJ. The current role of gallium imaging in infection. Semin Nucl Med. 1994;24:128–41.PubMedCrossRef
81.
Zurück zum Zitat Knockaert DC, Mortelmans LA, Deroo MC, Bobbaers HJ. Clinical-value of Ga-67 scintigraphy in evaluation of fever of unknown origin. Clin Infect Dis. 1994;18:601–5.PubMedCrossRef Knockaert DC, Mortelmans LA, Deroo MC, Bobbaers HJ. Clinical-value of Ga-67 scintigraphy in evaluation of fever of unknown origin. Clin Infect Dis. 1994;18:601–5.PubMedCrossRef
82.
Zurück zum Zitat Marienhagen J, Hennemann B, Andreesen R, Eilles C. In-111-oxine labeling of tumor-cytotoxic macrophages generated in vitro from circulating blood monocytes—an in vitro evaluation. Nucl Med Commun. 1995;16:357–61.PubMedCrossRef Marienhagen J, Hennemann B, Andreesen R, Eilles C. In-111-oxine labeling of tumor-cytotoxic macrophages generated in vitro from circulating blood monocytes—an in vitro evaluation. Nucl Med Commun. 1995;16:357–61.PubMedCrossRef
83.
Zurück zum Zitat van Hemert FJ, Thurlings R, Dohmen SE, Voennansc C, Tak PP, Eck-Smit BLF, et al. Labeling of autologous monocytes with Tc-99m-HMPAO at very high specific radioactivity. Nucl Med Biol. 2007;34:933–8.PubMedCrossRef van Hemert FJ, Thurlings R, Dohmen SE, Voennansc C, Tak PP, Eck-Smit BLF, et al. Labeling of autologous monocytes with Tc-99m-HMPAO at very high specific radioactivity. Nucl Med Biol. 2007;34:933–8.PubMedCrossRef
84.
Zurück zum Zitat van Hemert FJ, Voermans C, Eck-Smit BLF, Bennink RJ. Labeling monocytes for imaging chronic inflammation. Q J Nucl Med Mol Imaging. 2009;53:78–88.PubMed van Hemert FJ, Voermans C, Eck-Smit BLF, Bennink RJ. Labeling monocytes for imaging chronic inflammation. Q J Nucl Med Mol Imaging. 2009;53:78–88.PubMed
85.
Zurück zum Zitat Banati RB, Goerres GW, Myers R, Gunn RN, Turkheimer FE, Kreutzberg GW, et al. [C-11](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen’s encephalitis. Neurology. 1999;53:2199–203.PubMed Banati RB, Goerres GW, Myers R, Gunn RN, Turkheimer FE, Kreutzberg GW, et al. [C-11](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen’s encephalitis. Neurology. 1999;53:2199–203.PubMed
86.
Zurück zum Zitat Cagnin A, Myers R, Gunn RN, Lawrence AD, Stevens T, Kreutzberg GW, et al. In vivo visualization of activated glia by [C-11] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain. 2001;124:2014–27.PubMedCrossRef Cagnin A, Myers R, Gunn RN, Lawrence AD, Stevens T, Kreutzberg GW, et al. In vivo visualization of activated glia by [C-11] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain. 2001;124:2014–27.PubMedCrossRef
87.
Zurück zum Zitat Hammoud DA, Endres CJ, Chander AR, Guilarte TR, Wong DF, Sacktor NC, et al. Imaging glial cell activation with [C-11]-R-PK11195 in patients with AIDS. J Neurovirol. 2005;11:346–55.PubMedCrossRef Hammoud DA, Endres CJ, Chander AR, Guilarte TR, Wong DF, Sacktor NC, et al. Imaging glial cell activation with [C-11]-R-PK11195 in patients with AIDS. J Neurovirol. 2005;11:346–55.PubMedCrossRef
88.
Zurück zum Zitat Tahara N, Imaizumi T, Virmani R, Narula J. Clinical feasibility of molecular imaging of plaque inflammation in atherosclerosis. J Nucl Med. 2009;50:331–4.PubMedCrossRef Tahara N, Imaizumi T, Virmani R, Narula J. Clinical feasibility of molecular imaging of plaque inflammation in atherosclerosis. J Nucl Med. 2009;50:331–4.PubMedCrossRef
89.
Zurück zum Zitat Tokita N, Hasegawa S, Maruyama K, Izumi T, Blankenberg FG, Tait JF, et al. Tc-99m-Hynic-annexin V imaging to evaluate inflammation and apoptosis in rats with autoimmune myocarditis. Eur J Nucl Med Mol Imaging. 2003;30:232–8.PubMedCrossRef Tokita N, Hasegawa S, Maruyama K, Izumi T, Blankenberg FG, Tait JF, et al. Tc-99m-Hynic-annexin V imaging to evaluate inflammation and apoptosis in rats with autoimmune myocarditis. Eur J Nucl Med Mol Imaging. 2003;30:232–8.PubMedCrossRef
90.
Zurück zum Zitat Annovazzi A, D’Alessandria C, Bonanno E, Mather SJ, Cornelissen B, van de Wiele C, et al. Synthesis of Tc-99m-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes. Eur J Nucl Med Mol Imaging. 2006;33:474–82.PubMedCrossRef Annovazzi A, D’Alessandria C, Bonanno E, Mather SJ, Cornelissen B, van de Wiele C, et al. Synthesis of Tc-99m-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes. Eur J Nucl Med Mol Imaging. 2006;33:474–82.PubMedCrossRef
91.
Zurück zum Zitat Glaudemans AW, Dierckx RA, Kallenberg CG, Anzola Fuentes KL. The role of radiolabelled anti-TNFa monoclonal antibodies for diagnostic purposes and therapy evaluation. Q J Nucl Med Mol Imaging. 2010;54:639–53.PubMed Glaudemans AW, Dierckx RA, Kallenberg CG, Anzola Fuentes KL. The role of radiolabelled anti-TNFa monoclonal antibodies for diagnostic purposes and therapy evaluation. Q J Nucl Med Mol Imaging. 2010;54:639–53.PubMed
92.
Zurück zum Zitat Malviya G, D’Alessandria C, Bonanno E, Vexler V, Massari R, Trotta C, et al. Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes. J Nucl Med. 2009;50:1683–91.PubMedCrossRef Malviya G, D’Alessandria C, Bonanno E, Vexler V, Massari R, Trotta C, et al. Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes. J Nucl Med. 2009;50:1683–91.PubMedCrossRef
93.
Zurück zum Zitat Prager E, Wehrschuetz M, Bisail B, Woltsche M, Schwarz T, Lanz H, et al. Comparison of F-18-FDG and Ga-67-citrate in sarcoidosis imaging. Nuklearmedizin (Nucl Med). 2008;47:18–23. Prager E, Wehrschuetz M, Bisail B, Woltsche M, Schwarz T, Lanz H, et al. Comparison of F-18-FDG and Ga-67-citrate in sarcoidosis imaging. Nuklearmedizin (Nucl Med). 2008;47:18–23.
94.
Zurück zum Zitat Teirstein AS, Machac J, Almeida O, Lu P, Padilla ML, Iannuzzi MC. Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest. 2007;132:1949–53.PubMedCrossRef Teirstein AS, Machac J, Almeida O, Lu P, Padilla ML, Iannuzzi MC. Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest. 2007;132:1949–53.PubMedCrossRef
95.
Zurück zum Zitat Beckers C, Ribbens C, Andre B, Marcelis S, Kaye O, Mathy L, et al. Assessment of disease activity in rheumatoid arthritis with F-18-FDG PET. J Nucl Med. 2004;45:956–64.PubMed Beckers C, Ribbens C, Andre B, Marcelis S, Kaye O, Mathy L, et al. Assessment of disease activity in rheumatoid arthritis with F-18-FDG PET. J Nucl Med. 2004;45:956–64.PubMed
96.
Zurück zum Zitat Palmer WE, Rosenthal DI, Schoenberg OI, Fischman AJ, Simon LS, Rubin RH, et al. Quantification of inflammation in the wrist with gadolinium-enhanced MR-imaging and PET with 2-[F-18]-fluoro-2-deoxy-d-glucose. Radiology. 1995;196:647–55.PubMed Palmer WE, Rosenthal DI, Schoenberg OI, Fischman AJ, Simon LS, Rubin RH, et al. Quantification of inflammation in the wrist with gadolinium-enhanced MR-imaging and PET with 2-[F-18]-fluoro-2-deoxy-d-glucose. Radiology. 1995;196:647–55.PubMed
97.
Zurück zum Zitat Chianelli M, D’Alessandria C, Conti F, Priori R, Valesini G, Annovazzi A, et al. New radiopharmaceuticals for imaging rheumatoid arthritis. Q J Nucl Med Mol Imaging. 2006;50:217–25.PubMed Chianelli M, D’Alessandria C, Conti F, Priori R, Valesini G, Annovazzi A, et al. New radiopharmaceuticals for imaging rheumatoid arthritis. Q J Nucl Med Mol Imaging. 2006;50:217–25.PubMed
98.
Zurück zum Zitat Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo F-18-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol. 2006;48:1818–24.PubMedCrossRef Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo F-18-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol. 2006;48:1818–24.PubMedCrossRef
99.
Zurück zum Zitat Rudd JHF, Hyafil F, Fayad ZA. Inflammation imaging in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:1009–16.PubMedCrossRef Rudd JHF, Hyafil F, Fayad ZA. Inflammation imaging in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:1009–16.PubMedCrossRef
100.
Zurück zum Zitat Glaudemans AWJM, Slart RHJA, Bozzao A, Bonanno E, Arca M, Dierckx RAJO, et al. Molecular imaging in atherosclerosis. Eur J Nucl Med Mol Imaging. 2010;37:2381–97.PubMedCrossRef Glaudemans AWJM, Slart RHJA, Bozzao A, Bonanno E, Arca M, Dierckx RAJO, et al. Molecular imaging in atherosclerosis. Eur J Nucl Med Mol Imaging. 2010;37:2381–97.PubMedCrossRef
101.
Zurück zum Zitat Kinne RW, Becker W, Simon G, Paganelli G, PalomboKinne E, Wolski A, et al. Joint uptake and body distribution of a Tc-99M-labeled anti-rat-CD4 monoclonal-antibody in rat adjuvant arthritis. J Nucl Med. 1993;34:92–8.PubMed Kinne RW, Becker W, Simon G, Paganelli G, PalomboKinne E, Wolski A, et al. Joint uptake and body distribution of a Tc-99M-labeled anti-rat-CD4 monoclonal-antibody in rat adjuvant arthritis. J Nucl Med. 1993;34:92–8.PubMed
102.
Zurück zum Zitat Kinne RW, Becker W, Koscheck T, Kuhlmann J, Sharkey RM, Behr T, et al. Rat adjuvant arthritis - imaging with technetium-99M-anti-CD4 Fab’ fragments. J Nucl Med. 1995;36:2268–75.PubMed Kinne RW, Becker W, Koscheck T, Kuhlmann J, Sharkey RM, Behr T, et al. Rat adjuvant arthritis - imaging with technetium-99M-anti-CD4 Fab’ fragments. J Nucl Med. 1995;36:2268–75.PubMed
103.
Zurück zum Zitat Kinne RW, Becker W, Schwab J, Horneff G, Schwarz A, Kalden JR, et al. Comparison of (99)Tcm-labeled specific murine anti-CD4 monoclonal-antibodies and nonspecific human-immunoglobulin for imaging inflamed joints in rheumatoid-arthritis. Nucl Med Commun. 1993;14:667–75.PubMedCrossRef Kinne RW, Becker W, Schwab J, Horneff G, Schwarz A, Kalden JR, et al. Comparison of (99)Tcm-labeled specific murine anti-CD4 monoclonal-antibodies and nonspecific human-immunoglobulin for imaging inflamed joints in rheumatoid-arthritis. Nucl Med Commun. 1993;14:667–75.PubMedCrossRef
104.
Zurück zum Zitat Kinne RW, Wolski A, Palombo-Kinne E, Wolf F, Emmrich F, Becker W. Minimal contribution of cell-bound antibodies to the immunoscintigraphy of inflamed joints with Tc-99m-anti-CD4 monoclonal antibodies. Nuklearmedizin (Nucl Med). 2002;41:129–34. Kinne RW, Wolski A, Palombo-Kinne E, Wolf F, Emmrich F, Becker W. Minimal contribution of cell-bound antibodies to the immunoscintigraphy of inflamed joints with Tc-99m-anti-CD4 monoclonal antibodies. Nuklearmedizin (Nucl Med). 2002;41:129–34.
105.
Zurück zum Zitat Dalessandria C, Malviya G, Viscido A, Aratari A, Maccioni F, Amato A, et al. Use of a Tc-99m labeled anti-TNF alpha monoclonal antibody in Crohn’s disease: in vitro and in vivo studies. Q J Nucl Med Mol Imaging. 2007;51:334–42. Dalessandria C, Malviya G, Viscido A, Aratari A, Maccioni F, Amato A, et al. Use of a Tc-99m labeled anti-TNF alpha monoclonal antibody in Crohn’s disease: in vitro and in vivo studies. Q J Nucl Med Mol Imaging. 2007;51:334–42.
106.
Zurück zum Zitat Conti F, Priori R, Chimenti MS, Coari G, Annovazzi A, Valesini G, et al. Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy—a role for scintigraphy with Tc-99m-infliximab. Arthritis Rheum. 2005;52:1224–6.PubMedCrossRef Conti F, Priori R, Chimenti MS, Coari G, Annovazzi A, Valesini G, et al. Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy—a role for scintigraphy with Tc-99m-infliximab. Arthritis Rheum. 2005;52:1224–6.PubMedCrossRef
107.
Zurück zum Zitat Malviya G, Conti F, Chianelli M, Scopinaro F, Dierckx RA, Signore A. Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies. Eur J Nucl Med Mol Imaging. 2010;37:386–98.PubMedCrossRef Malviya G, Conti F, Chianelli M, Scopinaro F, Dierckx RA, Signore A. Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies. Eur J Nucl Med Mol Imaging. 2010;37:386–98.PubMedCrossRef
108.
Zurück zum Zitat Lucia P, Parisella MG, Danese C, Bruno F, Manetti LL, Capriotti G, et al. Diagnosis and followup of Takayasu’s arteritis by scintigraphy with radiolabelled interleukin 2. J Rheumatol. 2004;31:1225–7.PubMed Lucia P, Parisella MG, Danese C, Bruno F, Manetti LL, Capriotti G, et al. Diagnosis and followup of Takayasu’s arteritis by scintigraphy with radiolabelled interleukin 2. J Rheumatol. 2004;31:1225–7.PubMed
109.
Zurück zum Zitat Signore A, Chianelli M, Toscano A, Monetini L, Ronga G, Nimmon CC, et al. A radiopharmaceutical for imaging areas of lymphocytic infiltration—I-125 interleukin-2—labeling procedure and animal studies. Nucl Med Commun. 1992;13:713–22.PubMed Signore A, Chianelli M, Toscano A, Monetini L, Ronga G, Nimmon CC, et al. A radiopharmaceutical for imaging areas of lymphocytic infiltration—I-125 interleukin-2—labeling procedure and animal studies. Nucl Med Commun. 1992;13:713–22.PubMed
110.
Zurück zum Zitat Signore A, Chianelli M, Ferretti E, Tomei E, Pozzilli P, Ronga G, et al. Detection of pancreatic insulitis in type-1 diabetes by using 123I-labeled interleukin-2. Eur J Nucl Med. 1992;19:583. Signore A, Chianelli M, Ferretti E, Tomei E, Pozzilli P, Ronga G, et al. Detection of pancreatic insulitis in type-1 diabetes by using 123I-labeled interleukin-2. Eur J Nucl Med. 1992;19:583.
111.
Zurück zum Zitat Signore A, Chianelli M, Parisella MG, Capriotti G, Giacalone P, Di Leve G, et al. In vivo imaging of insulitis in autoimmune diabetes. J Endocrinol Invest. 1999;22:151–8.PubMed Signore A, Chianelli M, Parisella MG, Capriotti G, Giacalone P, Di Leve G, et al. In vivo imaging of insulitis in autoimmune diabetes. J Endocrinol Invest. 1999;22:151–8.PubMed
112.
Zurück zum Zitat Chianelli M, Parisella MG, Visalli N, Mather SJ, D’Alessandria C, Pozzilli P, et al. Pancreatic scintigraphy with 99mTc-interleukin-2 at diagnosis of type 1 diabetes and after 1 year of nicotinamide therapy. Diabetes Metab Res Rev. 2008;24:115–22.PubMedCrossRef Chianelli M, Parisella MG, Visalli N, Mather SJ, D’Alessandria C, Pozzilli P, et al. Pancreatic scintigraphy with 99mTc-interleukin-2 at diagnosis of type 1 diabetes and after 1 year of nicotinamide therapy. Diabetes Metab Res Rev. 2008;24:115–22.PubMedCrossRef
113.
Zurück zum Zitat Signore A, Chianelli M, Annovazzi A, Rosi M, Maiuri L, Greco M, et al. Imaging active lymphocytic infiltration in coeliac disease with iodine-123-interleukin-2 and the response to diet. Eur J Nucl Med. 2000;27:18–24.PubMedCrossRef Signore A, Chianelli M, Annovazzi A, Rosi M, Maiuri L, Greco M, et al. Imaging active lymphocytic infiltration in coeliac disease with iodine-123-interleukin-2 and the response to diet. Eur J Nucl Med. 2000;27:18–24.PubMedCrossRef
114.
Zurück zum Zitat Signore A, Chianelli M, Annovazzi A, Bonanno E, Spagnoli LG, Pozzilli P, et al. I-123-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohn’s disease. J Nucl Med. 2000;41:242–9.PubMed Signore A, Chianelli M, Annovazzi A, Bonanno E, Spagnoli LG, Pozzilli P, et al. I-123-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohn’s disease. J Nucl Med. 2000;41:242–9.PubMed
115.
Zurück zum Zitat Annovazzi A, Biancone L, Caviglia R, Chianelli M, Capriotti G, Mather SJ, et al. Tc-99m-interleukin-2 and Tc-99m-HMPAO granulocyte scintigraphy in patients with inactive Crohn’s disease. Eur J Nucl Med Mol Imaging. 2003;30:374–82.PubMedCrossRef Annovazzi A, Biancone L, Caviglia R, Chianelli M, Capriotti G, Mather SJ, et al. Tc-99m-interleukin-2 and Tc-99m-HMPAO granulocyte scintigraphy in patients with inactive Crohn’s disease. Eur J Nucl Med Mol Imaging. 2003;30:374–82.PubMedCrossRef
116.
Zurück zum Zitat Signore A, Annovazzi A, Barone R, Bonanno E, D’Alessandria C, Chianelli M, et al. Tc-99m-Interleukin-2 scintigraphy as a potential tool for evaluating tumor-infiltrating lymphocytes in melanoma lesions: a validation study. J Nucl Med. 2004;45:1647–52.PubMed Signore A, Annovazzi A, Barone R, Bonanno E, D’Alessandria C, Chianelli M, et al. Tc-99m-Interleukin-2 scintigraphy as a potential tool for evaluating tumor-infiltrating lymphocytes in melanoma lesions: a validation study. J Nucl Med. 2004;45:1647–52.PubMed
117.
Zurück zum Zitat Procaccini E, Chianelli M, Pantano P, Signore A. Imaging of autoimmune diseases. Q J Nucl Med. 1999;43:100–12.PubMed Procaccini E, Chianelli M, Pantano P, Signore A. Imaging of autoimmune diseases. Q J Nucl Med. 1999;43:100–12.PubMed
118.
Zurück zum Zitat Chianelli M, Mather SJ, Grossman A, Sobnak R, Fritzberg A, Britton KE, et al. Tc-99m-interleukin-2 scintigraphy in normal subjects and in patients with autoimmune thyroid diseases: a feasibility study. Eur J Nucl Med Mol Imaging. 2008;35:2286–93.PubMedCrossRef Chianelli M, Mather SJ, Grossman A, Sobnak R, Fritzberg A, Britton KE, et al. Tc-99m-interleukin-2 scintigraphy in normal subjects and in patients with autoimmune thyroid diseases: a feasibility study. Eur J Nucl Med Mol Imaging. 2008;35:2286–93.PubMedCrossRef
119.
Zurück zum Zitat Annovazzi A, Bonanno E, Arca M, D’Alessandria C, Marcoccia A, Spagnoli LG, et al. Tc-99m-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2006;33:117–26.PubMedCrossRef Annovazzi A, Bonanno E, Arca M, D’Alessandria C, Marcoccia A, Spagnoli LG, et al. Tc-99m-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2006;33:117–26.PubMedCrossRef
Metadaten
Titel
The molecular imaging approach to image infections and inflammation by nuclear medicine techniques
verfasst von
Alberto Signore
Andor W. J. M. Glaudemans
Publikationsdatum
01.12.2011
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 10/2011
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-011-0521-z

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