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01.10.2012 | Original article

Novel method for quantitative evaluation of cardiac amyloidosis using ²⁰¹TlCl and ^99mTc-PYP SPECT

verfasst von: Yasushi Yamamoto, Masahisa Onoguchi, Masuo Haramoto, Nobuhiro Kodani, Akio Komatsu, Hajime Kitagaki, Kazuaki Tanabe

Erschienen in: Annals of Nuclear Medicine | Ausgabe 8/2012

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Abstract

Objective

The degree of myocardial technetium-^99m-pyrophosphate (^99mTc-PYP) accumulation in cardiac amyloidosis is conventionally evaluated by the PYP score. This method involves qualitative visual evaluation on two-dimensional images. Here, we performed three-dimensional quantitative analysis using software developed in our laboratory.

Methods

We performed dual myocardial imaging using thallium-²⁰¹-chloride (²⁰¹Tl-Cl) and ^99mTc-PYP in cases of suspected cardiac amyloidosis and calculated the PYP accumulation rates of all myocardial pixels showing ^99mTc-PYP accumulation. We defined this procedure as quantitative evaluation of the degree of ^99mTc-PYP accumulation in the myocardium. Patients were divided into two groups with and without a diagnosis of cardiac amyloidosis, and we examined the PYP accumulation rates in both groups. In addition, we examined the PYP scores of the two groups by conventional qualitative evaluation.

Results

The PYP scores of the cardiac amyloidosis group were significantly higher than those of the other group. The PYP accumulation rates of the cardiac amyloidosis group were significantly higher than those of the other group. There were significant differences in the PYP accumulation rate and PYP score between the two groups. There was considered to be a threshold between the two groups in the case of the PYP accumulation rate.

Conclusions

When the threshold of the PYP score was defined as 3+ and that of the PYP accumulation rate as 41.5 %, the sensitivity of the PYP score and PYP accumulation rate was 84.6 %. However, the specificity of the PYP accumulation rate was higher than that of the PYP score. Quantitative evaluation by the PYP accumulation rate of the degree of ^99mTc-PYP accumulation in the myocardium may be useful in the diagnosis of cardiac amyloidosis.

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Titel: Novel method for quantitative evaluation of cardiac amyloidosis using 201TlCl and 99mTc-PYP SPECT
verfasst von: Yasushi Yamamoto
Masahisa Onoguchi
Masuo Haramoto
Nobuhiro Kodani
Akio Komatsu
Hajime Kitagaki
Kazuaki Tanabe
Publikationsdatum: 01.10.2012
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 8/2012
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-012-0627-y

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Novel method for quantitative evaluation of cardiac amyloidosis using ²⁰¹TlCl and ^99mTc-PYP SPECT

Abstract

Objective

Methods

Results

Conclusions

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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