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Annals of Nuclear Medicine

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01.02.2015 | Original Article

The potential usefulness of ¹⁸F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults

verfasst von: Jae Pil Hwang, Sang-Keun Woo, Sang Yun Yoon, Su Young Jeong

Erschienen in: Annals of Nuclear Medicine | Ausgabe 2/2015

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Abstract

Objective

The aim of this study was to evaluate the potential usefulness of ¹⁸F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.

Methods

614 subjects were enrolled in this retrospective study. They underwent both ¹⁸F-FDG PET/CT and colonoscopy in the same day as part of a cancer-screening program. Small focal FDG accumulation along the colorectum on ¹⁸F-FDG PET/CT images were compared with colonoscopy findings. Size of lesion was measured on colonoscopy and histology was determined by biopsy or polypectomy.

Results

In 614 ¹⁸F-FDG PET/CT images, 27 foci of FDG uptakes were observed in the colorectal area in 25 subjects. The overall sensitivity and specificity of ¹⁸F-FDG PET/CT were 5.6 and 96.8 %, respectively, but sensitivity to detect lesions larger than or equal to 1 cm was 25.8 %. On the ROC analysis, the optimal cut-off value for differentiating premalignant and malignant lesions from other benign conditions was 5.0 (sensitivity = 50 %, specificity = 88 %, AUC = 0.643).

Conclusions

Colonoscopic evaluation could be recommended by presence of focal colonic FDG uptake on ¹⁸F-FDG PET/CT, especially when SUV_max is over 5.

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Titel: The potential usefulness of 18F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults
verfasst von: Jae Pil Hwang
Sang-Keun Woo
Sang Yun Yoon
Su Young Jeong
Publikationsdatum: 01.02.2015
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 2/2015
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-014-0922-x

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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