Effects of left ventricular size on the accuracy of diastolic parameters derived from myocardial perfusion SPECT: comparison with tissue Doppler echocardiography

Impaired left ventricular (LV) diastolic function is a sensitive and early sign of myocardial ischemia. We evaluated the effects of LV size on the accuracy of diastolic parameters derived from SPECT.

There were 43 patients with end-systolic volume (ESV) of ≤10 ml, 43 patients with ESV of 11–20 ml and 65 patients with ESV of >20 ml. There were significant differences in PFR (p < 0.001), 1/3 MFR (p < 0.001) or TPFR/RR (p = 0.01) among the 3 groups. These diastolic parameters were increased with decreased LV size. In overall patients, PFR (r = 0.24, p = 0.003) and 1/3 MFR (r = 0.31, p < 0.001) were positively, and TPFR/RR (r = −0.23, p = 0.004) was inversely correlated with e′. Multivariate linear regression analyses showed that male gender (β = −0.14, p = 0.07; β = −0.16, p = 0.04), ESV (β = −0.63, p < 0.001; β = −0.45, p < 0.001) and e′ (β = 0.36, p < 0.001; β = 0.40, p < 0.001) were significant factors associated with PFR or 1/3 MFR. Multivariate linear regression analysis also showed that ESV (β = −0.17, p = 0.03) and e′ (β = −0.21, p = 0.01) were significant factors associated with TPFR/RR.