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Annals of Nuclear Medicine

Erschienen in:

27.08.2016 | Original Article

Automated quantification of amyloid positron emission tomography: a comparison of PMOD and MIMneuro

verfasst von: Woo Hee Choi, Yoo Hyun Um, Won Sang Jung, Sung Hoon Kim

Erschienen in: Annals of Nuclear Medicine | Ausgabe 10/2016

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Abstract

Objective

The aim of this study was to examine and compare two automated quantitative software tools (PMOD and MIMneuro) for the quantification of amyloid positron emission tomography (PET).

Methods

A total of 30 subjects—15 Alzheimer’s disease (AD) patients and 15 cognitively normal age- and sex-matched controls—were enrolled. All subjects underwent structural volumetric magnetic resonance imaging (MRI) and amyloid PET scans with F-18 florbetaben. Regional standardized uptake value ratios (SUVRs) using the cerebellar cortex as a reference region were obtained using PMOD and MIMneuro.

Results

The SUVRs using both PMOD and MIMneuro showed high discriminatory power between the AD patients and cognitively normal controls. While PMOD and MIMneuro yielded significantly different SUVRs in some brain regions, the two methods had good overall agreement.

Conclusion

MIMneuro provides comparable performance to PMOD without the need to acquire brain MRI. Therefore, MIMneuro might be suitable for clinical use to determine amyloid positivity.

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Titel: Automated quantification of amyloid positron emission tomography: a comparison of PMOD and MIMneuro
verfasst von: Woo Hee Choi
Yoo Hyun Um
Won Sang Jung
Sung Hoon Kim
Publikationsdatum: 27.08.2016
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 10/2016
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-016-1115-6

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

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