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Current Reviews in Musculoskeletal Medicine

Erschienen in:

07.02.2018 | Rotator Cuff Repair (M Tao and M Teusink, section editors)

The Role of Biologic Therapy in Rotator Cuff Tears and Repairs

verfasst von: Michael D. Charles, David R. Christian, Brian J. Cole

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 1/2018

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Abstract

Purpose of Review

The purpose of this review was to establish the foundation of the major biologic adjuvants to rotator cuff repairs and review recent scientific findings.

Recent Findings

Platelet-rich plasma (PRP) overall has no significant impact on functional outcomes and repair integrity, but may be more advantageous in small to medium tears. Further studies should focus on leukocyte-rich versus poor preparations and the use of PRP in patients that are high risk for repair failure. Biologic and synthetic patches or augments provide mechanical stability for large and massive rotator cuff tears and decrease re-tear rates. Mesenchymal stem cells have demonstrated improved healing rates without an impact on outcomes. Cytokines and growth factors show promise in animal models, but require human trials to further evaluate.

Summary

In massive or revision repairs, allograft or synthetic patch augmentation should be considered. Platelet-rich plasma may have benefit in smaller tears. Further studies are needed to evaluate the value of mesenchymal stem cells and various cytologic chemical signals.

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Titel: The Role of Biologic Therapy in Rotator Cuff Tears and Repairs
verfasst von: Michael D. Charles
David R. Christian
Brian J. Cole
Publikationsdatum: 07.02.2018
Verlag: Springer US
Erschienen in: Current Reviews in Musculoskeletal Medicine / Ausgabe 1/2018
Elektronische ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-018-9469-0

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The Role of Biologic Therapy in Rotator Cuff Tears and Repairs

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