Skip to main content
Erschienen in: Der Kardiologe 2/2016

01.04.2016 | Übersichten

Fraktionelle Flussreserve in der Diagnostik der koronaren Herzerkrankung

Klinische Bedeutung, Durchführung und Interpretation

verfasst von: Prof. Dr. H. Möllmann, T. Rudolph, J. Rieber, H. Eggebrecht, G. Richardt, T. Schmitz, N. Werner, S. Achenbach

Erschienen in: Die Kardiologie | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die invasive Bestimmung der fraktionellen Flussreserve („fractional flow reserve“, FFR) gestattet die Ermittlung der hämodynamischen Relevanz von Stenosen der Koronararterien. Verschiedene Studien konnten nachweisen, dass die Indikationsstellung zur myokardialen Revaskularisation, basierend auf den Ergebnissen einer FFR-Messung, mit einem verbesserten Outcome verbunden ist im Vergleich zur rein visuellen Quantifizierung des Schweregrades einer Stenose. Dies hat dazu geführt, dass die FFR-Messung Eingang in die Leitlinien gefunden hat. Die vorliegende Arbeit zeigt den theoretischen Hintergrund der FFR-Messung auf, fasst die entscheidenden klinischen Daten zusammen und bietet eine umfassende Praxisanleitung für die sichere und schnelle Durchführung der Messung im klinischen Alltag.
Literatur
1.
Zurück zum Zitat Pijls NH, De Bruyne B, Peels K et al (1996) Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 334(26):1703–1708CrossRefPubMed Pijls NH, De Bruyne B, Peels K et al (1996) Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 334(26):1703–1708CrossRefPubMed
2.
Zurück zum Zitat Windecker S, Kolh P, Alfonso F et al (2014) 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 35(37):2541–2619 Windecker S, Kolh P, Alfonso F et al (2014) 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 35(37):2541–2619
3.
Zurück zum Zitat Van Belle E, Rioufol G, Pouillot C et al (2014) Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry. Circulation 129(2):173–185CrossRefPubMed Van Belle E, Rioufol G, Pouillot C et al (2014) Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry. Circulation 129(2):173–185CrossRefPubMed
4.
Zurück zum Zitat Lachance P, Déry JP, Rodés-Cabau J et al (2008) Impact of fractional flow reserve measurement on the clinical management of patients with coronary artery disease evaluated with noninvasive stress tests prior to cardiac catheterization. Cardiovasc Revasc Med 9(4):229–234CrossRefPubMed Lachance P, Déry JP, Rodés-Cabau J et al (2008) Impact of fractional flow reserve measurement on the clinical management of patients with coronary artery disease evaluated with noninvasive stress tests prior to cardiac catheterization. Cardiovasc Revasc Med 9(4):229–234CrossRefPubMed
5.
Zurück zum Zitat Toth GG, Toth B, Johnson NP et al (2014) Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy. Circ Cardiovasc Interv 7(6):751–759CrossRefPubMed Toth GG, Toth B, Johnson NP et al (2014) Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy. Circ Cardiovasc Interv 7(6):751–759CrossRefPubMed
6.
Zurück zum Zitat AQUA-Institut (2014) AQUA-Qualitätssicherung 2008 und 2013. In: Deutsche Herzstiftung (Hrsg) Deutscher Herzbericht 2014. Deutsche Herzstiftung, Frankfurt am Main, S 63 AQUA-Institut (2014) AQUA-Qualitätssicherung 2008 und 2013. In: Deutsche Herzstiftung (Hrsg) Deutscher Herzbericht 2014. Deutsche Herzstiftung, Frankfurt am Main, S 63
7.
Zurück zum Zitat De Bruyne B, Pijls NH, Kalesan B et al (2012) Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med 367(11):991–1001CrossRefPubMed De Bruyne B, Pijls NH, Kalesan B et al (2012) Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med 367(11):991–1001CrossRefPubMed
8.
Zurück zum Zitat Bech GJW, De Bruyne B, Pijls NHJ et al (2001) Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial. Circulation 103(24):2928–2934CrossRefPubMed Bech GJW, De Bruyne B, Pijls NHJ et al (2001) Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial. Circulation 103(24):2928–2934CrossRefPubMed
9.
Zurück zum Zitat Pijls NHJ, van Schaardenburgh P, Manoharan G et al (2007) Percutaneous coronary intervention of functionally nonsignificant stenosis: 5‑year follow-up of the DEFER study. J Am Coll Cardiol 49(21):2105–2111CrossRefPubMed Pijls NHJ, van Schaardenburgh P, Manoharan G et al (2007) Percutaneous coronary intervention of functionally nonsignificant stenosis: 5‑year follow-up of the DEFER study. J Am Coll Cardiol 49(21):2105–2111CrossRefPubMed
10.
Zurück zum Zitat Pijls NHJ (2015) 15-year follow-up of the DEFER trial Presented at: EuroPCR; May 19, 2015; Paris, France Pijls NHJ (2015) 15-year follow-up of the DEFER trial Presented at: EuroPCR; May 19, 2015; Paris, France
11.
Zurück zum Zitat Tonino PAL, de Bruyne B, Pijls NHJ et al (2009) Fractional flow reserve versus angiography for guiding Percutaneous coronary intervention. N Engl J Med 360(3):213–224CrossRefPubMed Tonino PAL, de Bruyne B, Pijls NHJ et al (2009) Fractional flow reserve versus angiography for guiding Percutaneous coronary intervention. N Engl J Med 360(3):213–224CrossRefPubMed
12.
Zurück zum Zitat Pijls NHJ, Fearon WF, Tonino PAL et al (2010) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease : 2‑year follow-up of the FaME (fractional flow reserve versus Angiography for Multivessel evaluation) study. J Am Coll Cardiol 56(3):177–184CrossRefPubMed Pijls NHJ, Fearon WF, Tonino PAL et al (2010) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease : 2‑year follow-up of the FaME (fractional flow reserve versus Angiography for Multivessel evaluation) study. J Am Coll Cardiol 56(3):177–184CrossRefPubMed
13.
Zurück zum Zitat van Nunen LX, Zimmermann FM, Tonino PA et al (2015) Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5‑year follow-up of a randomised controlled trial. Lancet doi:10.1016/S0140-6736(15)00057-4 van Nunen LX, Zimmermann FM, Tonino PA et al (2015) Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5‑year follow-up of a randomised controlled trial. Lancet doi:10.1016/S0140-6736(15)00057-4
14.
Zurück zum Zitat De Bruyne D, Fearon WF, Pijls NHJ et al (2014) Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 371(13):1208–1217CrossRefPubMed De Bruyne D, Fearon WF, Pijls NHJ et al (2014) Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 371(13):1208–1217CrossRefPubMed
15.
Zurück zum Zitat Zhang D, Lv S, Xiantao SX et al (2015) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention: a meta-analysis. Heart 101(6):455–462CrossRefPubMedPubMedCentral Zhang D, Lv S, Xiantao SX et al (2015) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention: a meta-analysis. Heart 101(6):455–462CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Johnson NP, Tóth GG, Lai D et al (2014) Prognostic value of fractional flow reserve : linking physiologic severity to clinical outcomes. J Am Coll Cardiol 64(16):1641–1654CrossRefPubMed Johnson NP, Tóth GG, Lai D et al (2014) Prognostic value of fractional flow reserve : linking physiologic severity to clinical outcomes. J Am Coll Cardiol 64(16):1641–1654CrossRefPubMed
17.
Zurück zum Zitat Adjedj J, De Bruyne B, Floré V et al (2016) Significance of intermediate values of fractional flow reserve in patients with coronary artery disease. Circulation 133(5):502–508CrossRefPubMed Adjedj J, De Bruyne B, Floré V et al (2016) Significance of intermediate values of fractional flow reserve in patients with coronary artery disease. Circulation 133(5):502–508CrossRefPubMed
18.
Zurück zum Zitat Ozdemir M, Yazici GE, Turkoglu S et al (2007) Metoprolol does not effect myocardial fractional flow reserve in patients with intermediate coronary stenoses. Int Heart J 48(4):477–483CrossRefPubMed Ozdemir M, Yazici GE, Turkoglu S et al (2007) Metoprolol does not effect myocardial fractional flow reserve in patients with intermediate coronary stenoses. Int Heart J 48(4):477–483CrossRefPubMed
19.
Zurück zum Zitat Aqel RA, Zoghbi GJ, Trimm JR et al (2004) Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 93(3):343–346CrossRefPubMed Aqel RA, Zoghbi GJ, Trimm JR et al (2004) Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 93(3):343–346CrossRefPubMed
20.
Zurück zum Zitat Hage FG, Iskandrian AE (2012) The effect of caffeine on adenosine myocardial perfusion imaging: time to reassess? J Nucl Cardiol 19(3):415–419CrossRefPubMed Hage FG, Iskandrian AE (2012) The effect of caffeine on adenosine myocardial perfusion imaging: time to reassess? J Nucl Cardiol 19(3):415–419CrossRefPubMed
21.
Zurück zum Zitat Salcedo J, Kern MJ (2009) Effects of caffeine and theophylline on coronary hyperemia induced by adenosine or dipyridamole. Catheter Cardiovasc Interv 74(4):598–605CrossRefPubMed Salcedo J, Kern MJ (2009) Effects of caffeine and theophylline on coronary hyperemia induced by adenosine or dipyridamole. Catheter Cardiovasc Interv 74(4):598–605CrossRefPubMed
22.
Zurück zum Zitat Lindstaedt M, Bojara W, Holland-Letz T et al (2009) Adenosine-induced maximal coronary hyperemia for myocardial fractional flow reserve measurements: comparison of administration by femoral venous versus antecubital venous access. Clin Res Cardiol 98(11):717–723CrossRefPubMed Lindstaedt M, Bojara W, Holland-Letz T et al (2009) Adenosine-induced maximal coronary hyperemia for myocardial fractional flow reserve measurements: comparison of administration by femoral venous versus antecubital venous access. Clin Res Cardiol 98(11):717–723CrossRefPubMed
23.
Zurück zum Zitat Prasad A, Zareh M, Doherty R et al (2014) Use of regadenoson for measurement of fractional flow reserve. Catheter Cardiovasc Interv 83(3):369–374CrossRefPubMed Prasad A, Zareh M, Doherty R et al (2014) Use of regadenoson for measurement of fractional flow reserve. Catheter Cardiovasc Interv 83(3):369–374CrossRefPubMed
24.
Zurück zum Zitat Hakeem A, Uretsky B (2014) Regadenoson for FFR: time to say good-bye to adenosine? Catheter Cardiovasc Interv 83(3):375–376CrossRefPubMed Hakeem A, Uretsky B (2014) Regadenoson for FFR: time to say good-bye to adenosine? Catheter Cardiovasc Interv 83(3):375–376CrossRefPubMed
25.
Zurück zum Zitat Thomas GS, Tammelin BR, Schiffman GL et al (2008) Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial (RegCOPD trial). J Nucl Cardiol 15(3):319–328CrossRef Thomas GS, Tammelin BR, Schiffman GL et al (2008) Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial (RegCOPD trial). J Nucl Cardiol 15(3):319–328CrossRef
26.
Zurück zum Zitat Al Jaroudi W, Iskandrian AE (2009) Regadenoson: a new myocardial stress agent. J Am Coll Cardiol 54(13):1123–1130CrossRefPubMed Al Jaroudi W, Iskandrian AE (2009) Regadenoson: a new myocardial stress agent. J Am Coll Cardiol 54(13):1123–1130CrossRefPubMed
27.
Zurück zum Zitat Casella G, Leibig M, Schiele TM et al (2004) Are high doses of intracoronary adenosine an alternative to standard intravenous adenosine for the assessment of fractional flow reserve? Am Heart J 148(4):590–595CrossRefPubMed Casella G, Leibig M, Schiele TM et al (2004) Are high doses of intracoronary adenosine an alternative to standard intravenous adenosine for the assessment of fractional flow reserve? Am Heart J 148(4):590–595CrossRefPubMed
28.
Zurück zum Zitat Murtagh B, Higano S, Lennon R et al (2003) Role of incremental doses of intracoronary adenosine for fractional flow reserve assessment. Am Heart J 146(1):99–105CrossRefPubMed Murtagh B, Higano S, Lennon R et al (2003) Role of incremental doses of intracoronary adenosine for fractional flow reserve assessment. Am Heart J 146(1):99–105CrossRefPubMed
29.
Zurück zum Zitat De Luca G, Venegoni L, Iorio S et al (2011) Effects of increasing doses of intracoronary adenosine on the assessment of fractional flow reserve. JACC Cardiovasc Interv 4(10):1079–1084CrossRefPubMed De Luca G, Venegoni L, Iorio S et al (2011) Effects of increasing doses of intracoronary adenosine on the assessment of fractional flow reserve. JACC Cardiovasc Interv 4(10):1079–1084CrossRefPubMed
30.
Zurück zum Zitat Schlundt C, Bietau C, Klinghammer L et al (2015) Comparison of intracoronary versus intravenous administration of adenosine for measurement of coronary fractional flow reserve. Circ Cardiovasc Interv 8(5):e001781 doi:10.1161/CIRCINTERVENTIONS.114.001781CrossRefPubMed Schlundt C, Bietau C, Klinghammer L et al (2015) Comparison of intracoronary versus intravenous administration of adenosine for measurement of coronary fractional flow reserve. Circ Cardiovasc Interv 8(5):e001781 doi:10.1161/CIRCINTERVENTIONS.114.001781CrossRefPubMed
31.
Zurück zum Zitat Wilson RF, White CW (1986) Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans. Circulation 73(3):444–451CrossRefPubMed Wilson RF, White CW (1986) Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans. Circulation 73(3):444–451CrossRefPubMed
32.
Zurück zum Zitat Wilson RF, White CW (1988) Serious ventricular dysrhythmias after intracoronary papaverine. Am J Cardiol 62(17):1301–1302CrossRefPubMed Wilson RF, White CW (1988) Serious ventricular dysrhythmias after intracoronary papaverine. Am J Cardiol 62(17):1301–1302CrossRefPubMed
33.
Zurück zum Zitat Lim MJ, Kern MJ (2005) Utility of coronary physiologic hemodynamics for bifurcation, aorto-ostial, and ostial branch stenoses to guide treatment decisions. Catheter Cardiovasc Interv 65(4):461–468CrossRefPubMed Lim MJ, Kern MJ (2005) Utility of coronary physiologic hemodynamics for bifurcation, aorto-ostial, and ostial branch stenoses to guide treatment decisions. Catheter Cardiovasc Interv 65(4):461–468CrossRefPubMed
34.
Zurück zum Zitat Jokhi P, Curzen N (2009) Percutaneous coronary intervention of ostial lesions. EuroIntervention 5(4):511–514CrossRefPubMed Jokhi P, Curzen N (2009) Percutaneous coronary intervention of ostial lesions. EuroIntervention 5(4):511–514CrossRefPubMed
35.
Zurück zum Zitat Hamilos M, Muller O, Cuisset T et al (2009) Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis. Circulation 120(15):1505–1512CrossRefPubMed Hamilos M, Muller O, Cuisset T et al (2009) Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis. Circulation 120(15):1505–1512CrossRefPubMed
36.
Zurück zum Zitat Daniels DV, van’t Veer M, Pijls NHJ et al (2012) The impact of downstream coronary stenoses on fractional flow reserve assessment of intermediate left main disease. JACC Cardiovasc Interv 5(10):1021–1025CrossRefPubMed Daniels DV, van’t Veer M, Pijls NHJ et al (2012) The impact of downstream coronary stenoses on fractional flow reserve assessment of intermediate left main disease. JACC Cardiovasc Interv 5(10):1021–1025CrossRefPubMed
37.
Zurück zum Zitat Mallidi J, Atreya AR, Cook J et al (2015) Long-term outcomes following fractional flow reserve-guided treatment of angiographically ambiguous left main coronary artery disease: a meta-analysis of prospective cohort studies. Catheter Cardiovasc Interv 86(1):12–18CrossRefPubMed Mallidi J, Atreya AR, Cook J et al (2015) Long-term outcomes following fractional flow reserve-guided treatment of angiographically ambiguous left main coronary artery disease: a meta-analysis of prospective cohort studies. Catheter Cardiovasc Interv 86(1):12–18CrossRefPubMed
38.
Zurück zum Zitat Fearon W, Yong A (2015) The impact of downstream coronary stenosis on fractional flow reserve assessment of intermediate left main coronary artery disease: human validation. J Am Coll Cardiol Intv 8(3):398–403CrossRef Fearon W, Yong A (2015) The impact of downstream coronary stenosis on fractional flow reserve assessment of intermediate left main coronary artery disease: human validation. J Am Coll Cardiol Intv 8(3):398–403CrossRef
39.
Zurück zum Zitat Park SJ, Ahn JM, Pijls NH et al (2012) Validation of functional state of coronary tandem lesions using computational flow dynamics. Am J Cardiol 110(11):1578–1584CrossRefPubMed Park SJ, Ahn JM, Pijls NH et al (2012) Validation of functional state of coronary tandem lesions using computational flow dynamics. Am J Cardiol 110(11):1578–1584CrossRefPubMed
40.
Zurück zum Zitat Kim HL, Koo BK, Nam CW et al (2012) Clinical and physiological outcomes of fractional flow reserve-guided percutaneous coronary intervention in patients with serial stenoses within one coronary artery. JACC Cardiovasc Interv 5(10):1013–1018CrossRefPubMed Kim HL, Koo BK, Nam CW et al (2012) Clinical and physiological outcomes of fractional flow reserve-guided percutaneous coronary intervention in patients with serial stenoses within one coronary artery. JACC Cardiovasc Interv 5(10):1013–1018CrossRefPubMed
41.
Zurück zum Zitat De Bruyne B, Pijls NH, Heyndrickx GR et al (2000) Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation. Circulation 101(15):1840–1847CrossRefPubMed De Bruyne B, Pijls NH, Heyndrickx GR et al (2000) Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation. Circulation 101(15):1840–1847CrossRefPubMed
42.
Zurück zum Zitat Pijls NH, De Bruyne B, Bech GJ et al (2000) Coronary pressure measurement to assess the hemodynamic significance of serial stenoses within one coronary artery: validation in humans. Circulation 102(19):2371–2377CrossRefPubMed Pijls NH, De Bruyne B, Bech GJ et al (2000) Coronary pressure measurement to assess the hemodynamic significance of serial stenoses within one coronary artery: validation in humans. Circulation 102(19):2371–2377CrossRefPubMed
43.
Zurück zum Zitat Iguchi T, Hasegawa T, Nishimura S et al (2013) Impact of lesion length on functional significance in intermediate coronary lesions. Clin Cardiol 36(3):172–177CrossRefPubMed Iguchi T, Hasegawa T, Nishimura S et al (2013) Impact of lesion length on functional significance in intermediate coronary lesions. Clin Cardiol 36(3):172–177CrossRefPubMed
44.
Zurück zum Zitat López-Palop R, Carrillo P, Cordero A et al (2013) Effect of lesion length on functional significance of intermediate long coronary lesions. Catheter Cardiovasc Interv 81(4):E186–94CrossRefPubMed López-Palop R, Carrillo P, Cordero A et al (2013) Effect of lesion length on functional significance of intermediate long coronary lesions. Catheter Cardiovasc Interv 81(4):E186–94CrossRefPubMed
45.
Zurück zum Zitat Cuculi F, De Maria GL, Meier P et al (2014) Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. J Am Coll Cardiol 64(18):1894–1904CrossRefPubMed Cuculi F, De Maria GL, Meier P et al (2014) Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. J Am Coll Cardiol 64(18):1894–1904CrossRefPubMed
46.
Zurück zum Zitat Cuculi F, Dall’Armellina E, Manlhiot C et al (2014) Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction. Eur Heart J 35(29):1971–1980CrossRefPubMed Cuculi F, Dall’Armellina E, Manlhiot C et al (2014) Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction. Eur Heart J 35(29):1971–1980CrossRefPubMed
47.
Zurück zum Zitat Layland J, Carrick D, McEntegart M et al (2013) Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv 6(3):231–236CrossRefPubMed Layland J, Carrick D, McEntegart M et al (2013) Vasodilatory capacity of the coronary microcirculation is preserved in selected patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv 6(3):231–236CrossRefPubMed
48.
Zurück zum Zitat Ntalianis A, Sels JW, Davidavicius G et al (2010) Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction. JACC Cardiovasc Interv 3(12):1274–1281CrossRefPubMed Ntalianis A, Sels JW, Davidavicius G et al (2010) Fractional flow reserve for the assessment of nonculprit coronary artery stenoses in patients with acute myocardial infarction. JACC Cardiovasc Interv 3(12):1274–1281CrossRefPubMed
49.
Zurück zum Zitat Layland J, Rauhalammi S, Watkins S et al (2015) Assessment of fractional flow reserve in patients with recent non-ST-segment-elevation myocardial infarction: comparative study with 3‑T stress perfusion cardiac magnetic resonance imaging. Circ Cardiovasc Interv 8(8):e002207 doi:10.1161/CIRCINTERVENTIONS.114.002207CrossRefPubMed Layland J, Rauhalammi S, Watkins S et al (2015) Assessment of fractional flow reserve in patients with recent non-ST-segment-elevation myocardial infarction: comparative study with 3‑T stress perfusion cardiac magnetic resonance imaging. Circ Cardiovasc Interv 8(8):e002207 doi:10.1161/CIRCINTERVENTIONS.114.002207CrossRefPubMed
50.
Zurück zum Zitat Leesar MA, Abdul-Baki T, Akkus NI et al (2003) Use of fractional flow reserve versus stress perfusion scintigraphy after unstable angina. Effect on duration of hospitalization, cost, procedural characteristics, and clinical outcome. J Am Coll Cardiol 41(7):1115–1121CrossRefPubMed Leesar MA, Abdul-Baki T, Akkus NI et al (2003) Use of fractional flow reserve versus stress perfusion scintigraphy after unstable angina. Effect on duration of hospitalization, cost, procedural characteristics, and clinical outcome. J Am Coll Cardiol 41(7):1115–1121CrossRefPubMed
51.
Zurück zum Zitat Sels JW, Tonino PA, Siebert U et al (2011) Fractional flow reserve in unstable angina and non-ST-segment elevation myocardial infarction: experience from the FAME (Fractional flow reserve versus Angiography for Multivessel Evaluation) study. JACC Cardiovasc Interv 4(11):1183–1189CrossRefPubMed Sels JW, Tonino PA, Siebert U et al (2011) Fractional flow reserve in unstable angina and non-ST-segment elevation myocardial infarction: experience from the FAME (Fractional flow reserve versus Angiography for Multivessel Evaluation) study. JACC Cardiovasc Interv 4(11):1183–1189CrossRefPubMed
52.
Zurück zum Zitat Layland J, Oldroyd KG, Curzen N et al (2015) Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial. Eur Heart J 36(2):100–111CrossRefPubMedPubMedCentral Layland J, Oldroyd KG, Curzen N et al (2015) Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial. Eur Heart J 36(2):100–111CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Lopez-Palop R, Carrillo P, Torres F et al (2012) Results of fractional flow reserve measurement to evaluate nonculprit coronary artery stenoses in patients with acute coronary syndrome. Rev Esp Cardiol (Engl Ed) 65(2):164–170CrossRef Lopez-Palop R, Carrillo P, Torres F et al (2012) Results of fractional flow reserve measurement to evaluate nonculprit coronary artery stenoses in patients with acute coronary syndrome. Rev Esp Cardiol (Engl Ed) 65(2):164–170CrossRef
55.
Zurück zum Zitat Singh IM, Subbarao RA, Sadanandan S (2008) Limitation of fractional flow reserve in evaluating coronary artery myocardial bridge. J Invasive Cardiol 2:E161 Singh IM, Subbarao RA, Sadanandan S (2008) Limitation of fractional flow reserve in evaluating coronary artery myocardial bridge. J Invasive Cardiol 2:E161
56.
Zurück zum Zitat Gould KL, Johnson NP (2015) Myocardial Bridges: Lessons in Clinical Coronary Pathophysiology. JACC Cardiovasc Imaging 8:705–709CrossRefPubMed Gould KL, Johnson NP (2015) Myocardial Bridges: Lessons in Clinical Coronary Pathophysiology. JACC Cardiovasc Imaging 8:705–709CrossRefPubMed
57.
Zurück zum Zitat Pijls NH, Klauss V, Siebert U et al (2002) Coronary pressure measurement after stenting predicts adverse events at follow-up: a multicenter registry. Circulation 105(25):2950–2954CrossRefPubMed Pijls NH, Klauss V, Siebert U et al (2002) Coronary pressure measurement after stenting predicts adverse events at follow-up: a multicenter registry. Circulation 105(25):2950–2954CrossRefPubMed
58.
Zurück zum Zitat Rieber J, Schiele TM, Erdin P et al (2002) Fractional flow reserve predicts major adverse cardiac events after coronary stent implantation. Z Kardiol 3:132–136CrossRef Rieber J, Schiele TM, Erdin P et al (2002) Fractional flow reserve predicts major adverse cardiac events after coronary stent implantation. Z Kardiol 3:132–136CrossRef
59.
Zurück zum Zitat Hanekamp CEE, Koolen JJ, Pijls N et al (1999) Comparison of quantitative coronary angiography, intravascular ultrasound, and coronary pressure measurement to assess optimum stent deployment. Circulation 99(8):1015–1021CrossRefPubMed Hanekamp CEE, Koolen JJ, Pijls N et al (1999) Comparison of quantitative coronary angiography, intravascular ultrasound, and coronary pressure measurement to assess optimum stent deployment. Circulation 99(8):1015–1021CrossRefPubMed
60.
Zurück zum Zitat Chen S‑L, Ye F, Zhang J‑L et al (2015) Randomized comparison of FFR-guided and angiography-guided provisional Stenting of true coronary bifurcation lesions: the DKCRUSH-VI trial (double kissing crush versus provisional Stenting technique for treatment of coronary bifurcation lesions VI). JACC Cardiovasc Interv 8(4):536–546CrossRefPubMed Chen S‑L, Ye F, Zhang J‑L et al (2015) Randomized comparison of FFR-guided and angiography-guided provisional Stenting of true coronary bifurcation lesions: the DKCRUSH-VI trial (double kissing crush versus provisional Stenting technique for treatment of coronary bifurcation lesions VI). JACC Cardiovasc Interv 8(4):536–546CrossRefPubMed
61.
Zurück zum Zitat Tu S, Echavarria-Pinto M, von Birgelen C et al (2015) Fractional flow reserve and coronary bifurcation anatomy : a novel quantitative model to assess and report the stenosis severity of bifurcation lesions. JACC Cardiovasc Interv 8(4):564–574CrossRefPubMed Tu S, Echavarria-Pinto M, von Birgelen C et al (2015) Fractional flow reserve and coronary bifurcation anatomy : a novel quantitative model to assess and report the stenosis severity of bifurcation lesions. JACC Cardiovasc Interv 8(4):564–574CrossRefPubMed
62.
Zurück zum Zitat Koo BK, Park KW, Kang HJ et al (2008) Physiological evaluation of the provisional side-branch intervention strategy for bifurcation lesions using fractional flow reserve. Eur Heart J 29(6):726–732CrossRefPubMed Koo BK, Park KW, Kang HJ et al (2008) Physiological evaluation of the provisional side-branch intervention strategy for bifurcation lesions using fractional flow reserve. Eur Heart J 29(6):726–732CrossRefPubMed
63.
Zurück zum Zitat Sen S, Escaned J, Malik IS et al (2012) Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol 59(15):1392–1402CrossRefPubMed Sen S, Escaned J, Malik IS et al (2012) Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol 59(15):1392–1402CrossRefPubMed
64.
Zurück zum Zitat Petraco R, Al-Lamee R, Gotberg M et al (2014) Real-time use of instantaneous wave-free ratio: results of the ADVISE in-practice: an international, multicenter evaluation of instantaneous wave-free ratio in clinical practice. Am Heart J 168(5):739–748CrossRefPubMedPubMedCentral Petraco R, Al-Lamee R, Gotberg M et al (2014) Real-time use of instantaneous wave-free ratio: results of the ADVISE in-practice: an international, multicenter evaluation of instantaneous wave-free ratio in clinical practice. Am Heart J 168(5):739–748CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Berry C, van ’t Veer M, Witt N et al (2013) VERIFY (VERification of instantaneous wave-free ratio and fractional flow reserve for the assessment of coronary artery stenosis severity in everyday practice): a multicenter study in consecutive patients. J Am Coll Cardiol 61(13):1421–1427CrossRefPubMed Berry C, van ’t Veer M, Witt N et al (2013) VERIFY (VERification of instantaneous wave-free ratio and fractional flow reserve for the assessment of coronary artery stenosis severity in everyday practice): a multicenter study in consecutive patients. J Am Coll Cardiol 61(13):1421–1427CrossRefPubMed
66.
Zurück zum Zitat Jeremias A, Maehara A, Généreux P et al (2014) Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J Am Coll Cardiol 63(13):1253–1261CrossRefPubMed Jeremias A, Maehara A, Généreux P et al (2014) Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J Am Coll Cardiol 63(13):1253–1261CrossRefPubMed
67.
Zurück zum Zitat van de Hoef TP, Siebes M, Spaan JA et al (2015) Fundamentals in clinical coronary physiology: why coronary flow is more important than coronary pressure. Eur Heart J 36(47):3312–3319CrossRefPubMed van de Hoef TP, Siebes M, Spaan JA et al (2015) Fundamentals in clinical coronary physiology: why coronary flow is more important than coronary pressure. Eur Heart J 36(47):3312–3319CrossRefPubMed
68.
Zurück zum Zitat McClish JC, Ragosta M, Powers ER et al (2004) Effect of acute myocardial infarction on the utility of fractional flow reserve for the physiologic assessment of the severity of coronary artery narrowing. Am J Cardiol 93(9):1102–1106CrossRefPubMed McClish JC, Ragosta M, Powers ER et al (2004) Effect of acute myocardial infarction on the utility of fractional flow reserve for the physiologic assessment of the severity of coronary artery narrowing. Am J Cardiol 93(9):1102–1106CrossRefPubMed
69.
Zurück zum Zitat Pijls NH, Kern MJ, Yock PG et al (2000) Practice and potential pitfalls of coronary pressure measurement. Catheter Cardiovasc Interv 49(1):1–16CrossRefPubMed Pijls NH, Kern MJ, Yock PG et al (2000) Practice and potential pitfalls of coronary pressure measurement. Catheter Cardiovasc Interv 49(1):1–16CrossRefPubMed
70.
Zurück zum Zitat Claeys MJ, Bosmans JM, Hendrix J et al (2001) Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: importance of flow on translesional pressure gradient. Catheter Cardiovasc Interv 54(4):427–434CrossRefPubMed Claeys MJ, Bosmans JM, Hendrix J et al (2001) Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: importance of flow on translesional pressure gradient. Catheter Cardiovasc Interv 54(4):427–434CrossRefPubMed
71.
Zurück zum Zitat Verdier-Watts F, Rioufol G, Mewton N et al (2015) Influence of arterial hypotension on fractional flow reserve measurements. EuroIntervention 11(4):416–420CrossRefPubMed Verdier-Watts F, Rioufol G, Mewton N et al (2015) Influence of arterial hypotension on fractional flow reserve measurements. EuroIntervention 11(4):416–420CrossRefPubMed
72.
Zurück zum Zitat Seto AH, Tehrani DM, Bharmal MI et al (2014) Variations of coronary hemodynamic responses to intravenous adenosine infusion: implications for fractional flow reserve measurements. Catheter Cardiovasc Interv 84(3):416–425CrossRefPubMed Seto AH, Tehrani DM, Bharmal MI et al (2014) Variations of coronary hemodynamic responses to intravenous adenosine infusion: implications for fractional flow reserve measurements. Catheter Cardiovasc Interv 84(3):416–425CrossRefPubMed
73.
Zurück zum Zitat Min JK, Leipsic J, Pencina MJ et al (2012) Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA 308(12):1237–1245CrossRefPubMedPubMedCentral Min JK, Leipsic J, Pencina MJ et al (2012) Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA 308(12):1237–1245CrossRefPubMedPubMedCentral
74.
Zurück zum Zitat Koo BK, Erglis A, Doh JH et al (2011) Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol 58(19):1989–1997CrossRefPubMed Koo BK, Erglis A, Doh JH et al (2011) Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol 58(19):1989–1997CrossRefPubMed
75.
Zurück zum Zitat Norgaard BL, Leipsic J, Gaur S et al (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 63(12):1145–1155CrossRef Norgaard BL, Leipsic J, Gaur S et al (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 63(12):1145–1155CrossRef
76.
Zurück zum Zitat Gaur S, Bezerra HG, Lassen JF et al (2014) Fractional flow reserve derived from coronary CT angiography: variation of repeated analyses. J Cardiovasc Comput Tomogr 8(4):307–314CrossRefPubMed Gaur S, Bezerra HG, Lassen JF et al (2014) Fractional flow reserve derived from coronary CT angiography: variation of repeated analyses. J Cardiovasc Comput Tomogr 8(4):307–314CrossRefPubMed
77.
Zurück zum Zitat Morris PD, van de Vosse FN, Lawford PV et al (2015) “Virtual” (Computed) Fractional Flow Reserve: Current Challenges and Limitations. JACC Cardiovasc Interv 8(8):1009–1017CrossRefPubMedPubMedCentral Morris PD, van de Vosse FN, Lawford PV et al (2015) “Virtual” (Computed) Fractional Flow Reserve: Current Challenges and Limitations. JACC Cardiovasc Interv 8(8):1009–1017CrossRefPubMedPubMedCentral
78.
Zurück zum Zitat Morris PD, Ryan D, Morton AC et al (2013) Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study. JACC Cardiovasc Interv 6(2):149–157CrossRefPubMed Morris PD, Ryan D, Morton AC et al (2013) Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study. JACC Cardiovasc Interv 6(2):149–157CrossRefPubMed
79.
Zurück zum Zitat Papafaklis MI, Muramatsu T, Ishibashi Y et al (2014) Fast virtual functional assessment of intermediate coronary lesions using routine angiographic data and blood flow simulation in humans: comparison with pressure wire – fractional flow reserve. EuroIntervention 10(5):574–583CrossRefPubMed Papafaklis MI, Muramatsu T, Ishibashi Y et al (2014) Fast virtual functional assessment of intermediate coronary lesions using routine angiographic data and blood flow simulation in humans: comparison with pressure wire – fractional flow reserve. EuroIntervention 10(5):574–583CrossRefPubMed
80.
Zurück zum Zitat Tu S, Barbato E, Köszegi Z et al (2014) Fractional flow reserve calculation from 3‑dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries. JACC Cardiovasc Interv 7(7):768–777CrossRefPubMed Tu S, Barbato E, Köszegi Z et al (2014) Fractional flow reserve calculation from 3‑dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries. JACC Cardiovasc Interv 7(7):768–777CrossRefPubMed
81.
Zurück zum Zitat Tröbs M, Achenbach S, Röther J et al (2016) Comparison of fractional flow reserve based on computational fluid dynamics modeling using coronary angiographic vessel morphology versus Invasively measured fractional flow reserve. Am J Cardiol 117(1):29–35CrossRefPubMed Tröbs M, Achenbach S, Röther J et al (2016) Comparison of fractional flow reserve based on computational fluid dynamics modeling using coronary angiographic vessel morphology versus Invasively measured fractional flow reserve. Am J Cardiol 117(1):29–35CrossRefPubMed
82.
Zurück zum Zitat Zafar H, Sharif F, Leahy MJ (2014) Feasibility of intracoronary frequency domain optical coherence tomography derived fractional flow reserve for the assessment of coronary artery stenosis. Int Heart J 55(4):307–311CrossRefPubMed Zafar H, Sharif F, Leahy MJ (2014) Feasibility of intracoronary frequency domain optical coherence tomography derived fractional flow reserve for the assessment of coronary artery stenosis. Int Heart J 55(4):307–311CrossRefPubMed
83.
Zurück zum Zitat Zafar H, Ullah I, Dinneen K et al (2014) Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters. J Cardiol 64(1):19–24CrossRefPubMed Zafar H, Ullah I, Dinneen K et al (2014) Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters. J Cardiol 64(1):19–24CrossRefPubMed
Metadaten
Titel
Fraktionelle Flussreserve in der Diagnostik der koronaren Herzerkrankung
Klinische Bedeutung, Durchführung und Interpretation
verfasst von
Prof. Dr. H. Möllmann
T. Rudolph
J. Rieber
H. Eggebrecht
G. Richardt
T. Schmitz
N. Werner
S. Achenbach
Publikationsdatum
01.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Kardiologie / Ausgabe 2/2016
Print ISSN: 2731-7129
Elektronische ISSN: 2731-7137
DOI
https://doi.org/10.1007/s12181-016-0049-5

Weitere Artikel der Ausgabe 2/2016

Der Kardiologe 2/2016 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.