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International Journal of Hematology
Erschienen in: International Journal of Hematology 5/2016

23.03.2016 | Progress in Hematology

Cell cycle regulation of hematopoietic stem or progenitor cells

verfasst von: Sha Hao, Chen Chen, Tao Cheng

Erschienen in: International Journal of Hematology | Ausgabe 5/2016

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Abstract

The highly regulated process of blood production is achieved through the hierarchical organization of hematopoietic stem cell (HSC) subsets and their progenies, which differ in self-renewal and differentiation potential. Genetic studies in mice have demonstrated that cell cycle is tightly controlled by the complex interplay between extrinsic cues and intrinsic regulatory pathways involved in HSC self-renewal and differentiation. Deregulation of these cellular programs may transform HSCs or hematopoietic progenitor cells (HPCs) into disease-initiating stem cells, and can result in hematopoietic malignancies such as leukemia. While previous studies have shown roles for some cell cycle regulators and related signaling pathways in HSCs and HPCs, a more complete picture regarding the molecular mechanisms underlying cell cycle regulation in HSCs or HPCs is lacking. Based on accumulated studies in this field, the present review introduces the basic components of the cell cycle machinery and discusses their major cellular networks that regulate the dormancy and cell cycle progression of HSCs. Knowledge on this topic would help researchers and clinicians to better understand the pathogenesis of relevant blood disorders and to develop new strategies for therapeutic manipulation of HSCs.
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Metadaten
Titel
Cell cycle regulation of hematopoietic stem or progenitor cells
verfasst von
Sha Hao
Chen Chen
Tao Cheng
Publikationsdatum
23.03.2016
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 5/2016
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-016-1984-4

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