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Radiological Physics and Technology

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11.11.2017

Radiobiological analysis of stereotactic body radiation therapy for an evidence-based planning target volume of the lung using multiphase CT images obtained with a pneumatic abdominal compression apparatus: a case study

verfasst von: Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar

Erschienen in: Radiological Physics and Technology | Ausgabe 4/2017

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Abstract

This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose–volume parameters. Pneumatic abdominal compression improved the TCP by 15%. This novel protocol improved the TCP by 0.5% but reduced the NTCP for lung pneumonitis (0.2%) and rib fracture (1.0%). Beyond the observed variations in the patient’s treatment setup, the institutional protocol yielded a significantly consistent TCP (p < 0.005). The successful clinical outcome of this case study corroborates predictions based on radiobiological evaluation and deserves validation through an increased number of patients.

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Titel: Radiobiological analysis of stereotactic body radiation therapy for an evidence-based planning target volume of the lung using multiphase CT images obtained with a pneumatic abdominal compression apparatus: a case study
verfasst von: Arun Chairmadurai
Harish Chandra Goel
Sandeep Kumar Jain
Pawan Kumar
Publikationsdatum: 11.11.2017
Verlag: Springer Singapore
Erschienen in: Radiological Physics and Technology / Ausgabe 4/2017
Print ISSN: 1865-0333
Elektronische ISSN: 1865-0341
DOI: https://doi.org/10.1007/s12194-017-0431-4

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Radiobiological analysis of stereotactic body radiation therapy for an evidence-based planning target volume of the lung using multiphase CT images obtained with a pneumatic abdominal compression apparatus: a case study

Abstract

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