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01.09.2010

c-kit (CD117) Expression in Human Tumors and its Prognostic Value: An Immunohistochemical Analysis

verfasst von: Michael Medinger, Manuela Kleinschmidt, Klaus Mross, Barbara Wehmeyer, Clemens Unger, Hans-Eckart Schaefer, Renate Weber, Marc Azemar

Erschienen in: Pathology & Oncology Research | Ausgabe 3/2010

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Abstract

c-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types to their correlation with prognosis. Paraffin-embedded tumor tissues from 282 patients were analyzed immunohistochemically for c-kit expression. Survival and follow-up data were available from 192/282 (68%) patients. c-kit immunopositivity was found in 62/282 (22%) cases. c-kit expression was found in 14/83 (17%) colorectal cancers, in 13/62 (21%) breast cancers, in 7/20 sarcomas (35%), in 5/14 (36%) renal cell carcinomas, in 2/12 ovarian cancers (17%) and in 2/12 (17%) hepatocellular carcinomas. We found no significant correlation between c-kit expression and prognosis although a trend to a worse prognosis in patients with c-kit positive tumors could be observed. Expression of c-kit was found in tumor samples with varying intensities and infrequently.

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Titel: c-kit (CD117) Expression in Human Tumors and its Prognostic Value: An Immunohistochemical Analysis
verfasst von: Michael Medinger
Manuela Kleinschmidt
Klaus Mross
Barbara Wehmeyer
Clemens Unger
Hans-Eckart Schaefer
Renate Weber
Marc Azemar
Publikationsdatum: 01.09.2010
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 3/2010
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-010-9247-9

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