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Pathology & Oncology Research

Erschienen in:

01.10.2013 | Review

Klotho Acts as a Tumor Suppressor in Cancers

verfasst von: Biao Xie, Jinhui Chen, Bin Liu, Junkun Zhan

Erschienen in: Pathology & Oncology Research | Ausgabe 4/2013

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Abstract

The klotho gene is a classical “aging suppressor” gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of several types of human cancers. Klotho functions as a tumor suppressor by inhibiting insulin/IGF1, p53/p21, and Wnt signaling. Silencing klotho gene expression is mainly mediated through promoter hypermethylation and histone deacetylation in cancer. Klotho has been proposed to take part in cell proliferation, survival, autophagy, and resistance to anti-cancer therapies.

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Titel: Klotho Acts as a Tumor Suppressor in Cancers
verfasst von: Biao Xie
Jinhui Chen
Bin Liu
Junkun Zhan
Publikationsdatum: 01.10.2013
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 4/2013
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-013-9663-8

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Klotho Acts as a Tumor Suppressor in Cancers

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

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