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01.07.2015 | Research

Correlations Between Prognosis and Regional Biomarker Profiles in Head and Neck Squamous Cell Carcinomas

verfasst von: Gabriella Szentkúti, Kornél Dános, Diána Brauswetter, Gergő Kiszner, Tibor Krenács, László Csákó, Gábor Répássy, László Tamás

Erschienen in: Pathology & Oncology Research | Ausgabe 3/2015

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Abstract

Head and neck squamous cell carcinomas (HNSCC) show diverse clinicopathological features and are mostly linked with poor outcome. In this study, we tested if the expression of tumor growth, cell cycle and basement membrane anchorage related biomarkers allow prognostic and clinicopathological stratification of HNSCC. Archived HNSCC samples from 226 patients included into tissue microarrays (TMA) were tested using immunohistochemistry. Histopathological evaluation and the analysis of immunostaining for EGFR, Ki67, p53, p16^ink4 and Collagen XVII proteins were carried out in digital whole slides. Statistical evaluation was carried out using Pearson’s Chi-square test and Kaplan-Meier survival analysis. In the tested cohort, hypopharyngeal cancers had the least favorable, and glottic cancers had the most favorable prognosis. High Ki67 positive tumor cell fractions were associated with significantly worse prognosis and elevated rate of lymph node metastasis. Both Ki67 and EGFR expression correlated significantly with the tumor localization. Ki67 index was the highest in the hypopharyngeal region and it proved to be the lowest in the glottic region. EGFR expression was the highest in the oral cavity and the lowest in the glottic region. The survival rate of patients with p16^ink4-negative cancer was significantly lower than of those with p16^ink4-positive disease. A significant inverse correlation was found between histological grade and the prognosis of HNSCC. Our data support that elevated Ki67 positive proliferating cell fractions contribute to the unfavorable prognosis of hypopharyngeal cancers, while glottic cancers have the most favorable prognosis because of the lowest Ki67 expression rate.

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Titel: Correlations Between Prognosis and Regional Biomarker Profiles in Head and Neck Squamous Cell Carcinomas
verfasst von: Gabriella Szentkúti
Kornél Dános
Diána Brauswetter
Gergő Kiszner
Tibor Krenács
László Csákó
Gábor Répássy
László Tamás
Publikationsdatum: 01.07.2015
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 3/2015
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-014-9869-4

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Correlations Between Prognosis and Regional Biomarker Profiles in Head and Neck Squamous Cell Carcinomas

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