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Neuroscience Bulletin

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01.02.2019 | Original Article

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

verfasst von: Yu Deng, Xing Tan, Miao-Ling Li, Wei-Zhong Wang, Yang-Kai Wang

Erschienen in: Neuroscience Bulletin | Ausgabe 1/2019

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Abstract

The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.

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Titel: Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats
verfasst von: Yu Deng
Xing Tan
Miao-Ling Li
Wei-Zhong Wang
Yang-Kai Wang
Publikationsdatum: 01.02.2019
Verlag: Springer Singapore
Erschienen in: Neuroscience Bulletin / Ausgabe 1/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-018-0298-3

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Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

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