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Journal of Cardiovascular Translational Research
Erschienen in: Journal of Cardiovascular Translational Research 3/2010

01.06.2010

MicroRNAs in Cardiac Apoptosis

verfasst von: Peifeng Li

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 3/2010

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Abstract

MicroRNAs (miRNAs) are small and highly conserved non-coding RNA molecules that function to regulate gene expression. They play important roles in regulating cardiac physiological and pathological events such as hypertrophy, apoptosis, and heart failure. Induction of apoptosis in cardiomyocytes cannot be compensated by efficient cell proliferation, thereby leading to pathophysiological disorders. The miRNAs involved in cardiac apoptosis may provide a mechanism for the pathogenesis and treatment of heart diseases. This review summarizes the role of miRNAs in regulating cardiac apoptosis. In particular, it discusses the potential therapeutic approaches for apoptosis-related cardiac diseases by modulating miRNAs.
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Metadaten
Titel
MicroRNAs in Cardiac Apoptosis
verfasst von
Peifeng Li
Publikationsdatum
01.06.2010
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 3/2010
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-010-9175-9

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