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Journal of Cardiovascular Translational Research

Erschienen in:

01.02.2014

Randomized Comparison of Ticagrelor versus Prasugrel in Patients with Acute Coronary Syndrome and Planned Invasive Strategy—Design and Rationale of the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial

verfasst von: Stefanie Schulz, Dominick J. Angiolillo, David Antoniucci, Isabell Bernlochner, Christian Hamm, Juliane Jaitner, Karl-Ludwig Laugwitz, Katharina Mayer, Barbara von Merzljak, Tanja Morath, Franz-Josef Neumann, Gert Richardt, Judith Ruf, Gisela Schömig, Helmut Schühlen, Heribert Schunkert, Adnan Kastrati, Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial Investigators

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 1/2014

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Abstract

In acute coronary syndromes (ACS), a dual antiplatelet regimen with an adenosine diphosphate (ADP) receptor antagonist plus aspirin has become the cornerstone of treatment. The third-generation thienopyridine prasugrel and the cyclopentyl-triazolo-pyrimidine ticagrelor provide a greater, more rapid and consistent platelet inhibition compared to their predecessor clopidogrel. Based on their advantages over clopidogrel in two landmark studies, both drugs received a class I recommendation for their use in ACS patients with and without ST segment elevation. Due to differences in ACS populations and conditions investigated, the relative merits of ticagrelor versus prasugrel in the treatment of ACS patients with planned invasive strategy cannot be reliably estimated from independent trials. To date, no direct head-to-head comparison of ticagrelor and prasugrel in terms of clinical outcome exists. The aim of this multicenter, randomized, open-label trial is to assess whether ticagrelor is superior to prasugrel in ACS patients with planned invasive strategy.

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Titel: Randomized Comparison of Ticagrelor versus Prasugrel in Patients with Acute Coronary Syndrome and Planned Invasive Strategy—Design and Rationale of the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial
verfasst von: Stefanie Schulz
Dominick J. Angiolillo
David Antoniucci
Isabell Bernlochner
Christian Hamm
Juliane Jaitner
Karl-Ludwig Laugwitz
Katharina Mayer
Barbara von Merzljak
Tanja Morath
Franz-Josef Neumann
Gert Richardt
Judith Ruf
Gisela Schömig
Helmut Schühlen
Heribert Schunkert
Adnan Kastrati
Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial Investigators
Publikationsdatum: 01.02.2014
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 1/2014
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9527-3

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Randomized Comparison of Ticagrelor versus Prasugrel in Patients with Acute Coronary Syndrome and Planned Invasive Strategy—Design and Rationale of the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 Trial

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