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Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes

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Abstract

It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 Diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 Diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 Diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.

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Acknowledgments

The author was supported by grants from the American Diabetes Association (RA 110BS97), Pilot and Feasibility awards from the Boston Obesity Nutrition Research Center (DK046200, NIDDK) and NIH/NIDDK (DK80380).

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    Jongsoon Lee

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Lee, J. Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes. Arch. Pharm. Res. 36, 208–222 (2013). https://doi.org/10.1007/s12272-013-0023-8

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