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Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications

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Abstracts

Gold nanoparticles (AuNPs) can be readily synthesized and modified with chemical and biological molecules, making them attractive inorganic biomaterials for drug delivery and molecular diagnostics. The surface of AuNPs supports the efficient attachment of various biomacromolecules via chemisorption, chemical conjugation and electrostatic interaction. Based on advantages of facile surface modification and unique optical properties, AuNPs have been extensively used as drug carriers for the intracellular delivery of therapeutics as well as molecular nanoprobes for detection and monitoring of the target molecules of interest. In this review, we highlight advanced approaches in the biomedical applications of AuNPs such as gene and drug therapy, molecular diagnostics and imaging.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2012R1A1A1039030) and the Ewha Womans University Research Grant of 2013.

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Correspondence to Hyukjin Lee.

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Jeong, E.H., Jung, G., Hong, C.A. et al. Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications. Arch. Pharm. Res. 37, 53–59 (2014). https://doi.org/10.1007/s12272-013-0273-5

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  • DOI: https://doi.org/10.1007/s12272-013-0273-5

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