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Erschienen in: Breast Cancer 2/2008

01.04.2008 | Review Article

Basal-like subtype of breast cancer: a review of its unique characteristics and their clinical significance

verfasst von: Shunzo Kobayashi

Erschienen in: Breast Cancer | Ausgabe 2/2008

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Abstract

Subtyping of breast cancers by means of DNA microarray analyses has given rise to the new concept of the basal-like subtype; this subtype is in effect the equivalent of so-called “triple-negative” breast cancer. Basal-like breast cancer has aggressive characteristics, such as high histological grade, mutation of the TP53 gene, and negative hormone receptors. It tends to occur in relatively young women and is highly correlated with suppression of BRCA1 function. The EGFR gene is often overexpressed in this subtype. Here, research carried out in the last few years into the basal-like subtype of breast cancer will be reviewed.
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Metadaten
Titel
Basal-like subtype of breast cancer: a review of its unique characteristics and their clinical significance
verfasst von
Shunzo Kobayashi
Publikationsdatum
01.04.2008
Verlag
Springer Japan
Erschienen in
Breast Cancer / Ausgabe 2/2008
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-008-0034-3

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