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Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population

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Abstract

Platelet-endothelial cell adhesion molecule-1 (PECAM-1) has role in atherosclerotic plaque development as well as in thrombosis leading to myocardial infarction (MI). Present study was aimed to analyse the association of PECAM-1 Leu125Val gene polymorphism with MI in Indian population. Subjects included healthy individuals as control (N = 116) and MI patients (N = 100) divided into two groups; MI patients at presentation of the acute event (MI-Group-1, N = 46) and patients with recent event of MI stabilized with treatment 4.5 days from their symptoms (MI-Group-2, N = 54). The difference in the distribution of Leu125Val genotype frequencies of controls and patients did not reach statistical significance. However Leu allele frequency (0.57) was more associated with MI patients as compared to control (0.504). sPECAM-1 levels were significantly elevated in patients at acute event of MI (MI-Group-1) by 44.1% (P = 0.009) as compared to controls and by 95.2% (P = 0.001) as compared to stabilized MI patients (MI-Group-2).

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Authors and Affiliations

  1. Sir H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004, India

    Kavita K. Shalia, Rajashree A. Mokal, Shilpa M. Mithbawkar, Ketki V. Kudalkar, Ajin Abraham & Priti K. Thakur

  2. Department of Cardiology, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004, India

    Manoj R. Mashru, Surendra L. Soneji & Vinod K. Shah

  3. Department of Cardiology, Rajawadi Municipal Hospital, Ghatkopar (East), Mumbai, India

    Satchidanand Payannavar & Amar Walvalkar

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  1. Kavita K. Shalia
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  2. Manoj R. Mashru
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  3. Surendra L. Soneji
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Correspondence to Kavita K. Shalia.

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Shalia, K.K., Mashru, M.R., Soneji, S.L. et al. Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population. Indian J Clin Biochem 25, 273–279 (2010). https://doi.org/10.1007/s12291-010-0063-5

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