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Association of Inflammatory Biomarker C-Reactive Protein, Lipid Peroxidation and Antioxidant Capacity Marker with HbF Level in Sickle Cell Disease Patients from Chattisgarh

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Abstract

This study was undertaken to determine the association of inflammatory biomarker, oxidative stress and antioxidant capacity marker with fetal haemoglobin (HbF) level among sickle cell trait and sickle cell disease (SCD) patients in Chattisgarh. The study group consisted of 51 SCD (SS) patients with painful episode, 49 SCD (SS) patients with steady state, 50 sickle cell trait (AS) and 50 controls. Malondialdehyde (MDA), CRP, total antioxidant power (FARP), total thiol and HbF levels were quantified. We found a significant positive (p < 0.0001) association between CRP and MDA levels and its inverse association with HbF level in SS patients. We also observed that antioxidant capacity had significantly positively (p < 0.0001) associated with HbF level. The protective effect of HbF was found, because the increase in HbF levels resulted in decrease in lipid peroxidation and inflammation in SCD patients. A decrease in the HbF level and its antioxidant capacity has been associated with the pathogenesis of SCD. These finding may explain the high level of HbF is ameliorating oxidative stress and inflammation in SCD patients.

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Acknowledgments

The authors are thankful to all the donors of blood samples for the present study.

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Authors and Affiliations

  1. Department of Biochemistry, Pt. Jawahar Lal Nehru Memorial Medical College, Jail Road, Raipur, 492001, Chattisgarh, India

    Sanjana Bhagat & Pradeep Kumar Patra

  2. Department of Biochemistry, Govt. Medical College, Jagdalpur, Chattisgarh, India

    Amar Singh Thakur

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  1. Sanjana Bhagat
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  2. Pradeep Kumar Patra
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  3. Amar Singh Thakur
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Correspondence to Sanjana Bhagat.

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Bhagat, S., Patra, P.K. & Thakur, A.S. Association of Inflammatory Biomarker C-Reactive Protein, Lipid Peroxidation and Antioxidant Capacity Marker with HbF Level in Sickle Cell Disease Patients from Chattisgarh. Ind J Clin Biochem 27, 394–399 (2012). https://doi.org/10.1007/s12291-012-0231-x

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