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Estimation of Ischemia Modified Albumin (IMA) Levels in Patients with Acute Coronary Syndrome

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Abstract

Myocardial ischemia produces free radicals that catalyze a series of oxidative reactions that damage healthy tissues. The N-terminal sequence of albumin is one of the proteins modified by these highly reactive oxygen species and forms the ischemia modified albumin (IMA). This study involves investigations undertaken in different study groups to assess the levels of IMA. Mean serum IMA levels (U/mL) in patients with ST-segment elevated myocardial infarction (92.1 ± 10.6), non-ST-segment elevated myocardial infarction (87.3 ± 5.95) and unstable angina (UA) (88.9 ± 6.16) were significantly higher than non-cardiac chest pain (77.9 ± 6.69) and also healthy subjects (54.7 ± 17.2) (p < 0.001). IMA is a highly sensitive marker and has a high predictive value, which might prove the usefulness of this biomarker for early detection of myocardial ischemia. These data indicate a possible role of the IMA test in the early triage of patients with chest pain.

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Acknowledgments

We would like to thank Indian Council of Medical Research, New Delhi (BMS-52/14/2006) for the research Grant.

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Authors and Affiliations

  1. Department of Biochemistry, Frontier Lifeline Hospital & Dr. K. M. Cherian’s Heart Foundation, RC-30, Ambattur Estate Road, Mogappair, Chennai, 600101, Tamilnadu, India

    Prema Gurumurthy, Sai Krishna Borra, Rama Krishna Reddy Yeruva, Dolice Victor & Sai Babu

  2. Department of Cardiology, Frontier Lifeline Hospital & Dr. K. M. Cherian’s Heart Foundation, RC-30, Ambattur Estate Road, Mogappair, Chennai, 600101, Tamilnadu, India

    K. M. Cherian

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  1. Prema Gurumurthy
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  2. Sai Krishna Borra
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  4. Dolice Victor
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Correspondence to Prema Gurumurthy.

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Gurumurthy, P., Borra, S.K., Yeruva, R.K.R. et al. Estimation of Ischemia Modified Albumin (IMA) Levels in Patients with Acute Coronary Syndrome. Ind J Clin Biochem 29, 367–371 (2014). https://doi.org/10.1007/s12291-013-0367-3

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  • DOI: https://doi.org/10.1007/s12291-013-0367-3

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