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Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model

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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The medicinal plant, Terminalia bellirica (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it’s rejuvenating as well as health promoting effects. The present study evaluates protective role of aqueous acetone extract of T. bellirica fruits (AATB) against CCl4 induced liver toxicity in animal model. The liver damage was assessed by liver function markers including ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin and albumin-globulin ratio. The levels of MDA, ROS, and NO along with the tissue antioxidants were evaluated to assess hepatic oxidative stress and level of lipid peroxidation. Treatment with AATB prior to the exposure of CCl4 significantly reduced the damage when compared to the control rats. The outcome of the present study advocates the traditional use of the plant as ethnic food and health tonic.

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Acknowledgements

The authors are grateful to School of Biosciences and DBT-MSUB-IPLS (BUILDER) programme for providing the research facilities required for the study. J.K. gratefully acknowledges UGC for providing teacher fellowship under the UGC-FDP scheme. Authors acknowledge Dr. K.C. Pillai, Scientist, KFRI, Peechi, Kerala, India for providing the plant material.

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Authors and Affiliations

  1. School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India

    Kuriakose Jayesh, Lal Raisa Helen, A. Vysakh, Eldhose Binil & M. S. Latha

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  1. Kuriakose Jayesh
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  2. Lal Raisa Helen
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  3. A. Vysakh
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  4. Eldhose Binil
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Correspondence to M. S. Latha.

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This article does not contain any studies with human performed by any of the authors.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Jayesh, K., Helen, L.R., Vysakh, A. et al. Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Ind J Clin Biochem 34, 155–163 (2019). https://doi.org/10.1007/s12291-017-0732-8

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