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Grape Seed Extract Alleviates Dexamethasone-Induced Hyperlipidemia, Lipid Peroxidation, and Hematological Alteration in Rats

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Abstract

The ameliorative effects of dietary natural compounds have drawn increasing attention. Dietary antioxidant is considered a common practice adopted in traditional and alternative medicine. The current study was considered to assess the ameliorative effect of grape seed extract on dexamethasone-induced hepatotoxicity in rats. Rats were injected with dexamethasone, (0.1 mg/kg; i.m.), three times per week, for 30 days. The other groups; dexamethasone (0.1 mg/kg) and grape seed extract at a dose of 200 and 400 mg/kg were given orally to rats, respectively. Dexamethasone treatment resulted in a significant elevation in liver function markers activities, lipid profile, and hematological alterations; also, a remarkable increase in hepatic lipid peroxidation marker whereas decreased antioxidant activities in rats. However, administration of grape seed extract resulted in a reversal of dexamethasone-induced lipid peroxidation, antioxidant enzyme activities, liver function markers and lipid profile, and hematological alterations. Moreover, grape seed extract demonstrated preventive action against dexamethasone-induced histopathological changes in rat liver tissues. In conclusion, grape seed extract exhibited a protective effect in rats against oxidative stress, hyperlipidemia and hematological alterations induced by dexamethasone.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia

    Nabil Hasona

  2. Biochemistry Division, Chemistry Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt

    Nabil Hasona

  3. Pathology Department, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia

    Abdullah Morsi

Authors
  1. Nabil Hasona
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  2. Abdullah Morsi
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Correspondence to Nabil Hasona.

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The author declares that he has no conflict of interest.

Ethical Approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. The study protocol was approved by the Animal Ethics Committee in the College of medicine, Hail University.

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Hasona, N., Morsi, A. Grape Seed Extract Alleviates Dexamethasone-Induced Hyperlipidemia, Lipid Peroxidation, and Hematological Alteration in Rats. Ind J Clin Biochem 34, 213–218 (2019). https://doi.org/10.1007/s12291-018-0736-z

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  • DOI: https://doi.org/10.1007/s12291-018-0736-z

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