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Cancer Microenvironment
Erschienen in: Cancer Microenvironment 3/2011

01.12.2011

Immunosuppressive Tumor Microenvironment in Cervical Cancer Patients

verfasst von: Sytse J. Piersma

Erschienen in: Cancer Microenvironment | Ausgabe 3/2011

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Abstract

Cervical cancer is caused by Human papillomavirus (HPV) in virtually all cases. These HPV-induced cancers express the viral oncogenes E6 and E7 and are therefore potentially recognized by the immune system. Despite the abundant presence of these foreign antigens, the immune system is unable to cope with the tumor. Due to the constant immunological pressure, cervical cancers can evolve different immune evasion strategies, which will be described in the current review. Several approaches for immunotherapy of cervical cancer are currently under development, which aim at inducing strong HPV-specific immunity. Besides the reinforcement of potent anti-tumor immune responses, immunotherapy could also enhance HPV-specific T regulatory cells. Supplementary strategies that neutralize an immunosuppressive milieu may have great potential. These strategies are discussed as well.
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Metadaten
Titel
Immunosuppressive Tumor Microenvironment in Cervical Cancer Patients
verfasst von
Sytse J. Piersma
Publikationsdatum
01.12.2011
Verlag
Springer Netherlands
Erschienen in
Cancer Microenvironment / Ausgabe 3/2011
Print ISSN: 1875-2292
Elektronische ISSN: 1875-2284
DOI
https://doi.org/10.1007/s12307-011-0066-7

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