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Cancer Microenvironment

Erschienen in:

01.08.2013 | Original Article

Monocytes and Macrophages in Cancer: Development and Functions

verfasst von: David M. Richards, Jan Hettinger, Markus Feuerer

Erschienen in: Cancer Microenvironment | Ausgabe 2/2013

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Abstract

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local progression and distant metastasis. Therefore, targeting monocytes and macrophages is a promising immunotherapeutic approach. This review will focus on the development of monocytes as macrophage precursors, the functions of tumor-associated macrophages and the possibility of interfering with tumor development and progression by targeting these myeloid cells.

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Titel: Monocytes and Macrophages in Cancer: Development and Functions
verfasst von: David M. Richards
Jan Hettinger
Markus Feuerer
Publikationsdatum: 01.08.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Microenvironment / Ausgabe 2/2013
Print ISSN: 1875-2292
Elektronische ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-012-0123-x

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