Introduction
Indolent B cell neoplasms | ||
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2001 Classification | 2008 Classification | Notable aspects of 2008 classification |
Chronic lymphocytic leukemia/small lymphocytic leukemia | Chronic lymphocytic leukemia/small lymphocytic leukemia | Explicit requirement for ≥5 × 109/L monoclonal B cells with CLL phenotype, if extramedullary disease is absent. Monoclonal lymphocytosis of undertermined significance may be "precursor" lesion within the CLL/SLL spectrum |
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia | Lymphoplasmacytic lymphoma | As in 2008 definition |
Waldenström’s macroglobulinemia | Definition now incorporates the morphological diagnosis of LPL with bone marrow involvement, and due consideration given to the fact that IgM paraprotein may be present in non-LPL lymphomas | |
Splenic marginal zone lymphomia | Splenic B cell marginal zone lymphomia | As in 2008 definition |
Splenic B cell lymphoma/leukemia, unclassifiable
| ||
Splenic diffuse red pulp small B cell lymphoma
| Diffuse proliferation of small-sized lymphocytes predominantly localized to the spleen and bone marrow sinusoids but with villous projections. DBA44+, IgM+, IgD- | |
Hairy cell leukemia-variant
| Variant cytological features intermediate between HCL and B-PLL. Immunophenotype: DBA44+, CD11c+, sIg++, CD103+, TRAP-/+, CD25-/+, CD103-, CD123-, Annexin A1-. | |
Hairy cell leukemia | Hairy cell leukemia | As in 2008 definition |
Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) | Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) | As in 2008 definition |
Nodal marginal zone B cell lymphoma | Nodal marginal zone lymphoma | As in 2008 definition |
Pediatric nodal marginal zone lymphoma
| Distinct predilection for males, and histologically associated with proliferation around progressively transformed germinal centers | |
Follicular lymphoma | Follicular lymphoma | As in 2008 definition. Recognition of in situ follicular lymphoma |
Pediatric follicular lymphoma (variant)
| Recognition of a distinct follicular lymphoma variant in children distinct from adult disease and exhibiting a favorable prognosis with durable remissions as compared to adult disease | |
Extranodal follicular lymphoma | ||
Primary intestinal follicular lymphoma | Recognition of a distinct follicular lymphoma variant in bowel (often in duodenum) with excellent prognosis. Similar genetic features to nodal follicular lymphoma |