Erschienen in:
01.04.2010 | Original Article
Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT
verfasst von:
Fabio P. Esteves, MD, Jonathan A. Nye, PhD, Akbar Khan, MD, Russell D. Folks, CNMT, Raghuveer K. Halkar, MD, Ernest V. Garcia, PhD, David M. Schuster, MD, Stamatios Lerakis, MD, Paolo Raggi, MD, PhD, John R. Votaw, PhD
Erschienen in:
Journal of Nuclear Cardiology
|
Ausgabe 2/2010
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Abstract
Objective
To compare the diagnostic accuracy of Rb-82 myocardial perfusion three-dimensional (3D) PET with and without prompt-gamma compensation (PGC).
Methods and results
Retrospective, single center study of 76 patients who had rest and adenosine stress Rb-82 myocardial perfusion 3D PET. All studies were acquired using a Siemens Biograph-40 PET/CT scanner and were reconstructed with and without PGC. Fifty-seven patients (mean age 63 ± 11 years, 26 men) had coronary angiography within 40 days of Rb-82 imaging. Nineteen patients (mean age 43 ± 7 years, 10 men) had low likelihood of coronary artery disease (CAD). All PET images were scored by consensus of two blinded readers on a standard 5-point scale using a 17-segment left ventricular model. A normal PET test was defined as a summed stress score of less than four. Obstructive CAD at coronary angiography was used as the gold-standard and was defined as luminal stenoses ≥50% in one or more major coronary arteries. The prevalence of obstructive disease at coronary angiography was 68% (39/57). The mean summed stress score was 12 ± 12 for PGC images and was 18 ± 14 for non-PGC images. Sensitivity and specificity for obstructive CAD were 90% (95% CI 88-99) and 72% (95% CI 52-93) for PGC images and 95% (95% CI 88-100) and 22% (95% CI 3-41) for non-PGC images.
Conclusion
PGC in Rb-82 3D PET improves the specificity for obstructive CAD at coronary angiography with no significant loss in sensitivity.