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01.04.2011 | Original Article

Left-ventricular systolic and diastolic dyssynchrony as assessed by multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging in patients with end-stage renal disease and normal LVEF

verfasst von: Ji Chen, PhD, Andreas P. Kalogeropoulos, MD, Liudmila Verdes, MD, Javed Butler, MD, MPH, Ernest V. Garcia, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 2/2011

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Abstract

Background

The purpose of this study was to develop a multi-harmonic phase analysis method to measure diastolic dyssynchrony from conventional gated SPECT myocardial perfusion imaging (MPI) data and to compare it with systolic dyssynchrony in normal subjects and in patients with end-stage renal disease (ESRD) and normal left-ventricular ejection fraction (LVEF).

Methods

121 consecutive patients with ESRD and normal LVEF and 30 consecutive normal controls were enrolled. Diastolic dyssynchrony parameters were calculated using 3-harmonic phase analysis. Systolic dyssynchrony parameters were calculated using the established 1-harmonic phase analysis.

Results

The systolic and diastolic dyssynchrony parameters were correlated, but significantly different in both control and ESRD groups, indicating they were physiologically related but measured different LV mechanisms. The systolic and diastolic dyssynchrony parameters were each significantly different between the control and the ESRD groups. Significant systolic and diastolic dyssynchrony were found in 47% and 65% of the entire ESRD group.

Conclusion

Multi-harmonic phase analysis has been developed to assess diastolic dyssynchrony, which measured a new LV mechanism of regional function from gated SPECT MPI and showed a significantly higher prevalence rate than systolic dyssynchrony in patients with ESRD and normal LVEF.

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Titel: Left-ventricular systolic and diastolic dyssynchrony as assessed by multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging in patients with end-stage renal disease and normal LVEF
verfasst von: Ji Chen, PhD
Andreas P. Kalogeropoulos, MD
Liudmila Verdes, MD
Javed Butler, MD, MPH
Ernest V. Garcia, PhD
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 2/2011
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-010-9331-2

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Left-ventricular systolic and diastolic dyssynchrony as assessed by multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging in patients with end-stage renal disease and normal LVEF

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Conclusion

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