Introduction
Methods
Subjects
Cardiac 82Rb PET/CT MPI
Coronary Artery and TAC Scoring
Quantification of CFR
Statistical Analysis
Results
Parameter | Overall (n = 75) | Normal PET MPI (n = 46) | Abnormal PET MPI (n = 29) |
P value |
---|---|---|---|---|
Age | 59 ± 13 | 54 ± 1 | 67 ± 12 | .00001 |
Male gender | 37 (49%) | 17 (37%) | 20 (69%) | .009 |
Diabetes | 21 (28%) | 11 (24%) | 10 (35%) | ns |
Hypertension | 47 (63%) | 27 (59%) | 20 (69%) | ns |
Hyperlipidemia | 42 (56%) | 24 (52%) | 18 (62%) | ns |
Smoking | 7 (9%) | 4 (9%) | 3 (10%) | ns |
Family history | 16 (21%) | 12 (26%) | 4 (14%) | ns |
BMI | 32 ± 10 | 32 ± 9 | 32 ± 10 | ns |
CAC score | 288 ± 647 | 59 ± 182 | 651 ± 911 | .0001 |
CAC percentile | 55 ± 31 | 46 ± 32 | 69 ± 25 | .001 |
CFR | 2.1 ± 0.5 | 2.3 ± 0.5 | 1.8 ± 0.5 | .00001 |
TAC score | 877 ± 2,244 | 445 ± 1,562 | 1,563 ± 2,932 | .03 |
Rest | ||||
HR | 71 ± 11 | 70 ± 10 | 71 ± 13 | ns |
SBP | 134 ± 24 | 131 ± 26 | 139 ± 20 | ns |
DBP | 76 ± 14 | 76 ± 15 | 77 ± 11 | ns |
RPP | 9,523 ± 2,550 | 9,272 ± 2,419 | 9,921 ± 2,741 | ns |
Stress | ||||
HR | 92 ± 14 | 94 ± 13 | 89 ± 15 | ns |
SBP | 125 ± 19 | 123 ± 21 | 128 ± 17 | ns |
DBP | 68 ± 12 | 69 ± 14 | 68 ± 10 | ns |
RPP | 11,551 ± 2,644 | 11,587 ± 2,662 | 11,493 ± 2,662 | ns |
% d RPP | 0.2 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.2 | ns |
SRS | 1.2 ± 4.4 | 0.3 ± 0.8 | 2.6 ± 6.8 | .03 |
SSS | 3.3 ± 6.5 | 0.4 ± 0.9 | 7.9 ± 8.6 | .00001 |
SDS | 2.1 ± 4.5 | 0.1 ± 0.4 | 5.4 ± 6.0 | .00001 |
LVEF | 55 ± 12 | 57 ± 9 | 52 ± 11 | .05 |
The Relationships of CAC, TAC, and CFR with Severity of Ischemia
Mild, moderate & severe | Moderate & severe | |||||
---|---|---|---|---|---|---|
CAC | TAC | CFR | CAC | TAC | CFR | |
Sensitivity (%) | 79 (60–92) | 72 (53–87) | 83 (64–94) | 83 (52–97) | 75 (43–94) | 83 (52–97) |
Specificity (%) | 70 (54–82) | 65 (50–79) | 72 (57–84) | 83 (71–91) | 73 (60–83) | 62 (49–74) |
PPV (%) | 62 | 57 | 65 | 48 | 35 | 29 |
NPV (%) | 84 | 79 | 87 | 96 | 94 | 95 |
AUC | .85 (.75–.92)* | .74 (.63–.84)* | .77 (.66–.86) | .91 (.83–.97)** | .77 (.66–.86)** | .84 (.73–.91) |
Cut-Off | 20 | 100 | 1.97 | 100 | 250 | 1.94 |
Intercorrelation Between CAC, TAC, and CFR
CAC, TAC, and CFR by Age and Gender: Predictors of Ischemia
OR |
P value | CI | |
---|---|---|---|
CFR (≤2) | 0.13 | .0001 | 0.04–0.36 |
Age (≥65) | 9.00 | .0001 | 3.06–26.59 |
CAC (>50) | 12.47 | .0001 | 4.09–38.04 |
Gender (male) | 3.79 | .006 | 1.41–10.18 |
TAC | |||
Quartile 2 vs 1 | 3.43 | .17 | 0.59–19.80 |
Quartile 3 vs 1 | 5.82 | .046 | 1.03–32.79 |
Quartile 4 vs 1 | 20.80 | .001 | 3.45–125.29 |
Diabetes mellitus | 1.67 | .3 | 0.60–4.66 |
Hypertension | 1.56 | .4 | 0.59–4.17 |
Hyperlipidemia | 1.50 | .4 | 0.58–3.87 |
Smoking | 1.21 | .8 | 0.25–5.85 |
Family history | 2.20 | .2 | 0.63–7.65 |
BMI (≥25) | 1.01 | 1.0 | 0.34–3.00 |
LVEF (<40) | 0.60 | .2 | 0.11–3.22 |