Erschienen in:
01.06.2014 | Original Article
Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging
verfasst von:
Lena Johansson, BMSc, Lars Edenbrandt, MD, PhD, Kenichi Nakajima, MD, PhD, Milan Lomsky, MD, PhD, Sven-Eric Svensson, MD, PhD, Elin Trägårdh, MD, PhD
Erschienen in:
Journal of Nuclear Cardiology
|
Ausgabe 3/2014
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Abstract
Background
The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI HeartTM (EXINI), and PERFEXTM (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages.
Methods
We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPI studies. The reference standard classifications for the MPI studies were obtained from three experienced physicians who separately classified all cases regarding the presence or absence of ischemia and/or infarction. Automatic processing was carried out using EXINI and PERFEX to obtain CAD results and SSS values based on the 17-segment model.
Results
The three experts’ classifications showed ischemia in 257 patients and abnormal studies, i.e., either ischemia or infarction or both, in 318 patients. Accuracy was significantly higher in EXINI than in PERFEX, regarding both the detection of ischemia (87.4 vs 77.6%; P < 0.0001) and the detection of abnormal studies (91.6 vs 67.9%; P < 0.0001). EXINI’s CAD system showed a higher specificity than its SSS values (86.8 vs 73.6%; P < 0.0001) at the same level of sensitivity.
Conclusions
EXINI demonstrated greater diagnostic accuracy for detection of ischemia and abnormal studies than did PERFEX. EXINI CAD also outperformed its SSS analysis.