Excerpt

The assessment of left ventricular mechanical dyssynchrony (LVD) using phase analysis of gated myocardial perfusion SPECT (MPS) was introduced in 2005, allowing for the simultaneous assessment of left ventricular (LV) perfusion, function, and mechanical dyssynchrony.1 Phase analysis has shown excellent reproducibility and repeatability for assessing LVD.2 Also, compared to other imaging modalities, such as echocardiography, magnetic resonance imaging, and equilibrium radionuclide angiography, phase analysis of MPS has shown several advantages, such as simplicity, widespread availability, superior reproducibility, applicability to retrospective data, and ability to simultaneously assess myocardial scar location and severity for optimizing cardiac resynchronization therapy (CRT) in heart failure patients.3,4 Aljaroudi5 outlined other potential clinical applications of LVD including prognostication and risk stratification of patients with ischemic,6 non-ischemic cardiomyopathy,7 implantable defibrillators8, and end-stage renal disease.9,10 …