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01.02.2018 | Original Article

Routine evaluation of left ventricular function using CZT-SPECT, with low injected activities and limited recording times

verfasst von: Marine Claudin, MD, Laetitia Imbert, PhD, Wassila Djaballah, MD, Nicolas Veran, PharmD, Sylvain Poussier, PhD, Véronique Roch, CRA, Mathieu Perrin, MD, Antoine Verger, MD, Henri Boutley, Tech, Gilles Karcher, MD, PhD, Pierre-Yves Marie, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 1/2018

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Abstract

Purpose

Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI.

Methods

The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest). SPECT images were reconstructed with a method maintaining rather high spatial (8 mm) and temporal (16 frames/cycle) resolutions.

Results

Seventy-six patients were included, and mean effective dose was 3.5 ± 1.7 mSv for the total MPI protocol. Correlations between CZT-SPECT and MRI were good to excellent for ejection fraction (r ² = 0.77), end-diastolic (r ² = 0.88) and end-systolic (r ² = 0.93) volumes, and the analysis of segmental contractility correlated well between the two techniques (kappa score = 0.72 ± 0.02).

Conclusion

LV function, assessed on a CZT camera with low injected activities and limited recording times, correlates well with the reference assessment from cardiac MRI.

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Titel: Routine evaluation of left ventricular function using CZT-SPECT, with low injected activities and limited recording times
verfasst von: Marine Claudin, MD
Laetitia Imbert, PhD
Wassila Djaballah, MD
Nicolas Veran, PharmD
Sylvain Poussier, PhD
Véronique Roch, CRA
Mathieu Perrin, MD
Antoine Verger, MD
Henri Boutley, Tech
Gilles Karcher, MD, PhD
Pierre-Yves Marie, MD, PhD
Publikationsdatum: 01.02.2018
Verlag: Springer US
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 1/2018
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0615-z

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