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01.04.2018 | Original Article

Sympathetic cardiac function in early sepsis: Noninvasive evaluation with [¹²³I]-meta-iodobenzylguanidine (¹²³I-MIBG) in vivo SPECT imaging

verfasst von: Romain Clerc, MSc, Sophia Doll, MSc, Laurent M. Riou, PhD, Pascale Perret, PhD, Alexis Broisat, PhD, Audrey Soubies, BSc, Marie-Dominique Desruet, PharmD, PhD, Daniel Fagret, MD, PhD, Carole Schwebel, MD, PhD, Catherine Ghezzi, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 2/2018

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Abstract

Background

Sympathetic system abnormalities have been reported in sepsis-related cardiac dysfunction. The present study aimed at evaluating the potential of the norepinephrine radiolabeled analogue [¹²³I]-meta-iodobenzylguanidine (¹²³I-MIBG) for the noninvasive assessment of modifications in cardiac sympathetic activity occurring in lipopolysaccharide (LPS)-induced experimental acute sepsis by single-photon emission computed tomographic imaging (SPECT).

Methods and Results

Sepsis was induced in male Wistar rats by intraperitoneal injection of 10 mg·kg⁻¹ lipopolysaccharide (n = 16), whereas control animals (n = 7) were injected with vehicle (NaCl 0.9%). Echocardiography in LPS-injected animals (n = 8) demonstrated systolic and diastolic cardiac dysfunction. ¹²³I-MIBG was injected 1 hour after LPS or vehicle administration (n = 8 and 7, respectively), and in vivo SPECT imaging was performed early and late (20 and 180 minutes) after tracer injection prior to animal euthanasia and ex vivo assessment of ¹²³I-MIBG biodistribution. Global and 17-segment SPECT image analysis indicated that early ¹²³I-MIBG activity was not affected by LPS treatment, whereas late cardiac tracer activity was significantly decreased in LPS-treated animals. Consequently, the cardiac washout of ¹²³I-MIBG was significantly higher in LPS-treated (63.3% ± 4.0%) than that in control animals (56.7% ± 5.8%) (P < .05).

Conclusion

Sepsis-induced modifications in cardiac sympathetic nervous system activity were evidenced by noninvasive in vivo ¹²³I-MIBG SPECT imaging.

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Titel: Sympathetic cardiac function in early sepsis: Noninvasive evaluation with [123I]-meta-iodobenzylguanidine (123I-MIBG) in vivo SPECT imaging
verfasst von: Romain Clerc, MSc
Sophia Doll, MSc
Laurent M. Riou, PhD
Pascale Perret, PhD
Alexis Broisat, PhD
Audrey Soubies, BSc
Marie-Dominique Desruet, PharmD, PhD
Daniel Fagret, MD, PhD
Carole Schwebel, MD, PhD
Catherine Ghezzi, PhD
Publikationsdatum: 01.04.2018
Verlag: Springer US
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 2/2018
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0619-8

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Methods and Results

Conclusion

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