Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Journal of Nuclear Cardiology
Erschienen in: Journal of Nuclear Cardiology 4/2018

01.08.2018 | Review Article

Isolated cardiac sarcoidosis: A focused review of an under-recognized entity

verfasst von: David R. Okada, MD, Paco E. Bravo, MD, Tomas Vita, MD, Vikram Agarwal, MBBS, Michael T. Osborne, MD, Viviany R. Taqueti, MD, MPH, Hicham Skali, MD, MSc, Panithaya Chareonthaitawee, MD, Sharmila Dorbala, MD, MPH, Garrick Stewart, MD, Marcelo Di Carli, MD, Ron Blankstein, MD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

There is accumulating evidence for the existence of a phenotype of isolated cardiac sarcoidosis (ICS), or sarcoidosis that only involves the heart. In the absence of biopsy-confirmed cardiac sarcoidosis (CS), existing diagnostic criteria require the presence of extra-cardiac sarcoidosis as an inclusion criterion for the diagnosis of CS. Consequently, in the absence of a positive endomyocardial biopsy, ICS is not diagnosable by current guidelines. Therefore, there is uncertainty regarding the epidemiology, pathobiology, clinical characteristics, prognosis, and optimal treatment of ICS. This review will summarize the available data related to the prevalence and prognosis of ICS and will discuss challenges surrounding the diagnosis and management of this under-recognized entity.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736–55.CrossRef
2.
Longcope WT, Freiman DG. A study of sarcoidosis; based on a combined investigation of 160 cases including 30 autopsies from The Johns Hopkins Hospital and Massachusetts General Hospital. Medicine. 1952;31:1–132.CrossRefPubMed
3.
Silverman KJ, Hutchins GM, Bulkley BH. Cardiac sarcoid: A clinicopathologic study of 84 unselected patients with systemic sarcoidosis. Circulation. 1978;58:1204–11.CrossRefPubMed
4.
5.
Matsui Y, Iwai K, Tachibana T, Fruie T, Shigematsu N, Izumi T, Homma AH, Mikami R, Hongo O, Hiraga Y, Yamamoto M. Clinicopathological study of fatal myocardial sarcoidosis. Ann N Y Acad Sci. 1976;278:455–69.CrossRefPubMed
6.
Brown ML, Reeder G, Unni KK, Mullany C. Intraoperative diagnosis of isolated cardiac sarcoid. Heart Lung Circ. 2007;16:315–7.CrossRefPubMed
7.
White J, Sutton T, Kerr A. Isolated primary cardiac sarcoidosis: MRI diagnosis and monitoring of treatment response with cardiac enzymes. Circ Heart Fail. 2010;3:e28–9.CrossRefPubMed
8.
Kandolin R, Lehtonen J, Graner M, Schildt J, Salmenkivi K, Kivisto SM, Kupari M. Diagnosing isolated cardiac sarcoidosis. J Intern Med. 2011;270:461–8.CrossRefPubMed
9.
Chang TI, Chi NH, Chou NK, Tsao CI, Yu HY, Chen YS, Wang SS. Isolated cardiac sarcoidosis in heart transplantation. Transpl Proc. 2012;44:903–6.CrossRef
10.
Tsai JH, Chou NK, Wang SS, Shun CT. Isolated cardiac sarcoidosis: case experience in heart transplantation. J Formos Med Assoc. 2013;112:499–500.CrossRefPubMed
11.
Chinitz JS, Inra LA, Stein KM, Weinsaft JW. Isolated cardiac sarcoid in a patient with unexplained syncope. J Cardiovasc Electrophysiol. 2010;21:333.CrossRefPubMed
12.
Mc Ardle BA. Leung E, Ohira H, Cocker MS, deKemp RA, DaSilva J, Birnie D, Beanlands RS and Nery PB. The role of F(18)-fluorodeoxyglucose positron emission tomography in guiding diagnosis and management in patients with known or suspected cardiac sarcoidosis. J Nucl Cardiol. 2013;20:297–306.
13.
Nery PB, Keren A, Healey J, Leug E, Beanlands RS, Birnie DH. Isolated cardiac sarcoidosis: Establishing the diagnosis with electroanatomic mapping-guided endomyocardial biopsy. Can J Cardiol. 1015;29:e1–3.
14.
Sugizaki Y, Tanaka H, Imanishi J, Konishi A, Yamashita T, Shinke T, Ishida T, Kawai H, Hirata K. Isolated primary cardiac sarcoidosis presenting as acute heart failure. Intern Med. 2013;52:71–4.CrossRefPubMed
15.
Adamson P, Melton I, O’Donnell J, MacDonald S, Crozier I. Cardiac sarcoidosis: The Christchurch experience. Intern Med J. 2014;44:70–6.CrossRefPubMed
16.
Nery PB, Mc Ardle BA, Redpath CJ, Leung E, Lemery R, Dekemp R, et al. Prevalence of cardiac sarcoidosis in patients presenting with monomorphic ventricular tachycardia. Pacing Clin Electrophysiol. 2014;37:364–74.
17.
Galati G, Leone O, Rapezzi C. The difficult diagnosis of isolated cardiac sarcoidosis: Usefulness of an integrated MRI and PET approach. Heart. 2014;100:89–90.CrossRefPubMed
18.
19.
Ehl NF, Maeder MT, Joerg L. Isolated cardiac sarcoidosis: Critical role of cardiac MRI for diagnosis and management. Eur Heart J. 2015;36:3434.CrossRefPubMed
20.
Kandolin R, Lehtonen J, Airaksinen J, Vihinen T, Miettinen H, Ylitalo K, Kaikkonen K, Tuohinen S, Haataja P, Kerola T, Kokkonen J, Pelkonen M, Pietila-Effati P, Utrianen S, Kupari M. Cardiac sarcoidosis: Epidemiology, characteristics, and outcome over 25 years in a nationwide study. Circulation. 2015;131:624–32.CrossRefPubMed
21.
Tezuka D, Terashima M, Kato Y, Toriihara A, Hirasawa K, Sasaoka T, Yoshikawa S, Maejima Y, Ashikaga T, Suzuki J, Hirao K, Isobe M. Clinical characteristics of definite or suspected isolated cardiac sarcoidosis: Application of cardiac magnetic resonance imaging and 18F-Fluoro-2-deoxyglucose positron-emission tomography/computerized tomography. J Card Fail. 2015;21:313–22.CrossRefPubMed
22.
Sperry BW, Oldan J, Hachamovitch R, Tamarappoo BK. Insights into biopsy-proven cardiac sarcoidosis in patients with heart failure. J Heart Lung Transpl. 2016;35:392–3.CrossRef
23.
Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R. American Heart A, American College of C and European Society of C. The role of endomyocardial biopsy in the management of cardiovascular disease: A scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation. 2007;116:2216–33.CrossRefPubMed
24.
Uemura A, Morimoto S, Hiramitsu S, Kato Y, Ito T, Hishida H. Histologic diagnostic rate of cardiac sarcoidosis: Evaluation of endomyocardial biopsies. Am Heart J. 1999;138:299–302.CrossRefPubMed
25.
Tavora F, Cresswell N, Li L, Ripple M, Solomon C, Burke A. Comparison of necropsy findings in patients with sarcoidosis dying suddenly from cardiac sarcoidosis versus dying suddenly from other causes. Am J Cardiol. 2009;104:571–7.CrossRefPubMed
26.
Patel MR, Cawley PJ, Heitner JF, Klem I, Parker MA, Jaroudi WA, Meine TJ, White JB, Elliott MD, Kim HW, Judd RM, Kim RJ. Detection of myocardial damage in patients with sarcoidosis. Circulation. 2009;120:1969–77.CrossRefPubMedPubMedCentral
27.
Otsuka K, Terasaki F, Eishi Y, Shimomura H, Ogura Y, Horii T, Isomura T, Suma H, Kitaura Y. Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: Importance of mediastinal lymphadenopathy in differential diagnosis. Circ J. 2007;71:1937–41.CrossRefPubMed
28.
Ishimaru S, Tsujino I, Takei T, Tsukamoto E, Sakaue S, Kamigaki M, Ito N, Ohira H, Ikeda D, Tamaki N, Nishimura M. Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis. Eur Heart J. 2005;26:1538–43.CrossRefPubMed
29.
Blankstein R, Osborne M, Naya M, Waller A, Kim CK, Murthy VL, Kazemian P, Kwong RY, Tokuda M, Skali H, Padera R, Hainer J, Stevenson WG, Dorbala S, Di Carli MF. Cardiac positron emission tomography enhances prognostic assessments of patients with suspected cardiac sarcoidosis. J Am Coll Cardiol. 2014;63:329–36.CrossRefPubMed
30.
Blankstein R, Waller AH. Evaluation of known or suspected cardiac sarcoidosis. Circ Cardiovasc Imaging. 2016;9:e000867.CrossRefPubMed
31.
Soussan M, Brillet PY, Nunes H, Pop G, Ouvrier MJ, Naggara N, Valeyre D, Weinmann P. Clinical value of a high-fat and low-carbohydrate diet before FDG-PET/CT for evaluation of patients with suspected cardiac sarcoidosis. J Nucl Cardiol. 2013;20:120–7.CrossRefPubMed
32.
Orii M, Hirata K, Tanimoto T, Ota S, Shiono Y, Yamano T, Matsuo Y, Ino Y, Yamaguchi T, Kubo T, Tanaka A, Akasaka T. Comparison of cardiac MRI and 18F-FDG positron emission tomography manifestations and regional response to corticosteroid therapy in newly diagnosed cardiac sarcoidosis with complet heart block. Heart Rhythm. 2015;12:2477–85.CrossRefPubMed
33.
Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, et al. Comparison of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis. Eur J Nucl Med Mol Imaging. 2016;43:259–69.
34.
Kron J, Sauer W, Mueller G, Schuller J, Bogun F, Sarsam S, Rosenfeld L, Mitiku TY, Cooper JM, Mehta D, Greenspon AJ, Ortman M, Delurgio DB, Valadri R, Narasimhan C, Swapna N, Singh JP, Danik S, Markowitz SM, Almquist AK, Krahn AD, Wolfe LG, Feinstein S, Ellenbogen KA, Crawford T. Outcomes of patients with definite and suspected isolated cardiac sarcoidosis treated with an implantable cardiac defibrillator. J Interv Card Electrophysiol. 2015;43:55–64.CrossRefPubMed
35.
Chiu CZ, Nakatani S, Zhang G, Tachibana T, Ohmori F, Yamagishi M, Kitakaze M, Tomoike H, Miyatake K. Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. Am J Cardiol. 2005;95:143–6.CrossRefPubMed
36.
Osborne MT, Hulten EA, Singh A, Waller AH, Bittencourt MS, Stewart GC, Hainer J, Murthy VL, Skali H, Dorbala S, Di Carli MF, Blankstein R. Reduction in (1)(8)F-fluorodeoxyglucose uptake on serial cardiac positron emission tomography is associated with improved left ventricular ejection fraction in patients with cardiac sarcoidosis. J Nucl Cardiol. 2014;21:166–74.CrossRefPubMed
37.
Oni AA, Hershberger RE, Norman DJ, Ray J, Hovaguimian H, Cobanoglu AM, Hosenpud JD. Recurrence of sarcoidosis in a cardiac allograft: Control with augmented corticosteroids. J Heart Lung Transpl. 1992;11:367–9.
38.
Yager JE, Hernandez AF, Steenbergen C, Persing B, Russell SD, Milano C, Felker GM. Recurrence of cardiac sarcoidosis in a heart transplant recipient. J Heart Lung Transpl. 2005;24:1988–90.CrossRef
39.
Luk A, Lee A, Ahn E, Soor GS, Ross HJ, Butany J. Cardiac sarcoidosis: Recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. Can J Cardiol. 2010;26:e273–5.CrossRefPubMedPubMedCentral
40.
Osborne M, Kolli S, Padera RF, Naya M, Lewis E, Dorbala S, Di Carli MF, Blankstein R. Use of multimodality imaging to diagnose cardiac sarcoidosis as well as identify recurrence following heart transplantation. J Nucl Cardiol. 2013;20:310–2.CrossRefPubMed
41.
Tung R, Bauer B, Schelbert H, Lynch JP 3rd, Auerbach M, Gupta P, Schiepers C, Chan S, Ferris J, Barrio M, Ajijola O, Bradfield J, Shivkumar K. Incidence of abnormal positron emission tomography in patients with unexplained cardiomyopathy and ventricular arrhythmias: The potential role of occult inflammation in arrhythmogenesis. Heart Rhythm. 2015;12:2488–98.CrossRefPubMedPubMedCentral
42.
Osborne MT, Hulten EA, Murthy VL, Skali H, Taqueti VR, Dorbala S, et al. Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. J Nucl Cardiol. 2016.
43.
Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, Judson MA, Kron J, Mehta D, Cosedis Nielsen J, Patel AR, Ohe T, Raatikainen P, Soejima K. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm. 2014;11(7):1305–23.
44.
Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31:19–27.
45.
Norikane T, Yamamoto Y, Maeda Y, Noma T, Nishiyama Y. 18F-FLT PET imaging in a patient with sarcoidosis with cardiac involvement. Clin Nucl Med. 2015;40:433–4.
46.
Reiter T, Werner RA, Bauer WR, Lapa C. Detection of cardiac sarcoidosis by macrophage-directed somatostatin receptor 2-based positron emission tomography/computed tomography. Eur Heart J. 2015;36:2404.
Metadaten
Titel
Isolated cardiac sarcoidosis: A focused review of an under-recognized entity
verfasst von
David R. Okada, MD
Paco E. Bravo, MD
Tomas Vita, MD
Vikram Agarwal, MBBS
Michael T. Osborne, MD
Viviany R. Taqueti, MD, MPH
Hicham Skali, MD, MSc
Panithaya Chareonthaitawee, MD
Sharmila Dorbala, MD, MPH
Garrick Stewart, MD
Marcelo Di Carli, MD
Ron Blankstein, MD
Publikationsdatum
01.08.2018
Verlag
Springer US
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 4/2018
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-016-0658-1

Weitere Artikel der Ausgabe 4/2018

Journal of Nuclear Cardiology 4/2018 Zur Ausgabe

Editorial

A further step towards getting cardiac respiratory motion under control

Editorial

Role of myocardial perfusion scintigraphy in octogenarians: Time for reappraisal?

Review Article

Radiopharmaceutical tracers for cardiac imaging

ASNC PRESIDENT’S MESSAGE

The ASNC Industry Forum: Advancing a Cherished Relationship

Editorial

Imaging of cardiac sympathetic activity in heart failure: Not out of the woods yet

Technical Corner

Count density curves for gated SPECT myocardial perfusion imaging studies: An overview of technical considerations, patterns in various arrhythmia-related artifacts, and a technologist’s guide for curve plotting

Neu im Fachgebiet Kardiologie

23.04.2024 | Ablationstherapie | Nachrichten

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 | Prävention und Rehabilitation in der Kardiologie | Nachrichten

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

19.04.2024 | Vorhofflimmern | Nachrichten

Parodontalbehandlung verbessert Prognose bei Katheterablation

18.04.2024 | Arterielle Hypertonie | Nachrichten

Antihypertensiva schützen auch alte Menschen noch vor Demenz
weitere anzeigen

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen