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01.02.2018 | Original Article

Early-phase myocardial uptake intensity of ^99mTc-HMDP vs ^99mTc-DPD in patients with hereditary transthyretin-related cardiac amyloidosis

verfasst von: Mukedaisi Abulizi, MD, Anne-Ségolène Cottereau, MD, Aziz Guellich, PhD, Stéphanie Vandeventer, MD, Arnault Galat, MD, Axel Van Der Gucht, MD, Violaine Plante-Bordeneuve, MD, PhD, Jean-Luc Dubois-Randé, MD, PhD, Diane Bodez, MD, Jean Rosso, MD, Thibaud Damy, MD, PhD, Emmanuel Itti, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 1/2018

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Abstract

Background

This study sought to compare the intensity of early-phase myocardial uptake of two phosphonate-based radiotracers, ^99mTc-hydroxymethylene diphosphonate (HMDP) and ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), in patients with hereditary transthyretin-related cardiac amyloidosis (TTR-CA).

Methods

Six patients with biopsy-proven diagnosis of TTR-CA and characteristic amyloid fibril composition underwent early-phase ^99mTc-HMDP myocardial scintigraphy as part of their routine workup; they were later assessed by ^99mTc-DPD scintigraphy after having signed informed written consent. Heart-to-mediastinum-ratio was measured at both time points as well as regional distribution on 17-segment analysis.

Results

All patients had an H/M ratio >1.28 on both imaging. ^99mTc-DPD uptake was slightly higher than ^99mTc-HMDP uptake in 3 patients, but no statistical difference was found (P = 0.13). Regional distribution of the two radiotracers was well correlated on bull’s eyes analysis, with only slight underestimation of ^99mTc-DPD uptake in the anterior/apical segments, compared with ^99mTc-HMDP.

Conclusion

^99mTc-HMDP and ^99mTc-DPD show comparable myocardial uptake intensity on early-phase scintigraphy and can be used alternatively for the diagnosis of TTR-CA.

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Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003;349:583–96.CrossRefPubMed

Rowczenio DM, Noor I, Gillmore JD, Lachmann HJ, Whelan C, Hawkins PN, et al. Online registry for mutations in hereditary amyloidosis including nomenclature recommendations. Hum Mutat 2014;35:E2403–12.CrossRefPubMed

Coelho T, Maurer MS, Suhr OB. THAOS—the transthyretin amyloidosis outcomes survey: initial report on clinical manifestations in patients with hereditary and wild-type transthyretin amyloidosis. Curr Med Res Opin 2013;29:63–76.CrossRefPubMed

Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016;133:2404–12.CrossRefPubMed

Galat A, Van der Gucht A, Guellich A, Bodez D, Cottereau AS, Guendouz S et al. Early Phase ⁹⁹Tc-HMDP Scintigraphy for the Diagnosis and Typing of Cardiac Amyloidosis. JACC Cardiovasc Imaging 2016;in press.

Perugini E, Guidalotti PL, Salvi F, Cooke RM, Pettinato C, Riva L, et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J Am Coll Cardiol 2005;46:1076–84.CrossRefPubMed

Rapezzi C, Quarta CC, Guidalotti PL, Pettinato C, Fanti S, Leone O, et al. Role of (99 m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis. JACC Cardiovasc Imaging 2011;4:659–70.CrossRefPubMed

Hutt DF, Quigley AM, Page J, Hall ML, Burniston M, Gopaul D, et al. Utility and limitations of 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in systemic amyloidosis. Eur Heart J Cardiovasc Imaging 2014;15:1289–98.CrossRefPubMed

Glaudemans AW, van Rheenen RW, van den Berg MP, Noordzij W, Koole M, Blokzijl H, et al. Bone scintigraphy with (99m)technetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis. Amyloid 2014;21:35–44.CrossRefPubMed

10.

Galat A, Rosso J, Guellich A, Van Der Gucht A, Rappeneau S, Bodez D, et al. Usefulness of (99m)Tc-HMDP scintigraphy for the etiologic diagnosis and prognosis of cardiac amyloidosis. Amyloid 2015;22:210–20.CrossRefPubMed

11.

Castano A, DeLuca A, Weinberg R, Pozniakoff T, Blaner WS, Pirmohamed A et al. Serial scanning with technetium pyrophosphate (^99mTc-PYP) in advanced ATTR cardiac amyloidosis. J Nucl Cardiol 2015.

12.

Worsley DF, Lentle BC. Uptake of technetium-99m MDP in primary amyloidosis with a review of the mechanisms of soft tissue localization of bone seeking radiopharmaceuticals. J Nucl Med 1993;34:1612–5.PubMed

13.

Kulhanek J, Movahed A. Uptake of technetium 99m HDP in cardiac amyloidosis. Int J Cardiovasc Imaging 2003;19:225–7.CrossRefPubMed

14.

Van Der Gucht A, Galat A, Rosso J, Guellich A, Garot J, Bodez D, et al. [¹⁸F]NaF PET/CT imaging in cardiac amyloidosis. J Nucl Cardiol 2016;23:846–9.CrossRef

15.

Kula RW, Engel WK, Line BR. Scanning for soft-tissue amyloid. Lancet 1977;1:92–3.CrossRefPubMed

16.

Bodez D, Ternacle J, Guellich A, Galat A, Lim P, Radu C et al. Prognostic value of right ventricular systolic function in cardiac amyloidosis. Amyloid 2016;23:158–67.CrossRefPubMed

17.

Germano G, Kavanagh PB, Waechter P, Areeda J, Van Kriekinge S, Sharir T, et al. A new algorithm for the quantitation of myocardial perfusion SPECT. I: technical principles and reproducibility. J Nucl Med 2000;41:712–9.PubMed

18.

Buroni F, Persico MG, Lodola L, Concardi M, Aprile C. In vitro study: binding of ^99mTc-DPD to synthetic amyloid fibrils. Curr Issues Pharm Med Sci 2015;28:231–5.

19.

Lakkis NM, He ZX, Verani MS. Diagnosis of coronary artery disease by exercise thallium-201 tomography in patients with a right ventricular pacemaker. J Am Coll Cardiol 1997;29:1221–5.CrossRefPubMed

Titel: Early-phase myocardial uptake intensity of 99mTc-HMDP vs 99mTc-DPD in patients with hereditary transthyretin-related cardiac amyloidosis
verfasst von: Mukedaisi Abulizi, MD
Anne-Ségolène Cottereau, MD
Aziz Guellich, PhD
Stéphanie Vandeventer, MD
Arnault Galat, MD
Axel Van Der Gucht, MD
Violaine Plante-Bordeneuve, MD, PhD
Jean-Luc Dubois-Randé, MD, PhD
Diane Bodez, MD
Jean Rosso, MD
Thibaud Damy, MD, PhD
Emmanuel Itti, MD, PhD
Publikationsdatum: 01.02.2018
Verlag: Springer US
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 1/2018
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0707-9

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Early-phase myocardial uptake intensity of ^99mTc-HMDP vs ^99mTc-DPD in patients with hereditary transthyretin-related cardiac amyloidosis

Abstract

Background

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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