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01.10.2018 | Original Article

First assessment of simultaneous dual isotope (¹²³I/^99mTc) cardiac SPECT on two different CZT cameras: A phantom study

verfasst von: Tanguy Blaire, MD, Alban Bailliez, MD, PhD, Fayçal Ben Bouallegue, PhD, Dimitri Bellevre, MD, Denis Agostini, MD, PhD, Alain Manrique, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 5/2018

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Abstract

Background

We studied the impact of simultaneous dual-isotope acquisition on ¹²³I/^99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International).

Methods

We used an anthropomorphic torso phantom (respectively filled with a solution of ¹²³I alone, ^99mTc alone, and a mixture of ¹²³I and ^99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated.

Results

The acquisition mode (single vs dual) significantly impacted (i) ^99mTc (but not ¹²³I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using ¹²³I and DNM 530c, P < .0001; and using both ¹²³I and ^99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin’s concordance correlation coefficient and Bland–Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (¹²³I and ^99mTc).

Conclusions

This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on ¹²³I and ^99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.

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Titel: First assessment of simultaneous dual isotope (123I/99mTc) cardiac SPECT on two different CZT cameras: A phantom study
verfasst von: Tanguy Blaire, MD
Alban Bailliez, MD, PhD
Fayçal Ben Bouallegue, PhD
Dimitri Bellevre, MD
Denis Agostini, MD, PhD
Alain Manrique, MD, PhD
Publikationsdatum: 01.10.2018
Verlag: Springer US
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 5/2018
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-0841-z

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First assessment of simultaneous dual isotope (¹²³I/^99mTc) cardiac SPECT on two different CZT cameras: A phantom study

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Background

Methods

Results

Conclusions

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