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Erschienen in: Journal of Nuclear Cardiology 4/2017

01.08.2017 | ASNC Consensus Statement

Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease—state-of-the-evidence and clinical recommendations

verfasst von: Viviany R. Taqueti, MD, MPH, Sharmila Dorbala, MD, MPH, David Wolinsky, MD, Brian Abbott, MD, Gary V. Heller, MD, PhD, Timothy M. Bateman, MD, Jennifer H. Mieres, MD, Lawrence M. Phillips, MD, Nanette K. Wenger, MD, Leslee J. Shaw, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2017

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Abstract

This document from the American Society of Nuclear Cardiology represents an updated consensus statement on the evidence base of stress myocardial perfusion imaging (MPI), emphasizing new developments in single-photon emission tomography (SPECT) and positron emission tomography (PET) in the clinical evaluation of women presenting with symptoms of stable ischemic heart disease (SIHD). The clinical evaluation of symptomatic women is challenging due to their varying clinical presentation, clinical risk factor burden, high degree of comorbidity, and increased risk of major ischemic heart disease events. Evidence is substantial that both SPECT and PET MPI effectively risk stratify women with SIHD. The addition of coronary flow reserve (CFR) with PET improves risk detection, including for women with nonobstructive coronary artery disease and coronary microvascular dysfunction. With the advent of PET with computed tomography (CT), multiparametric imaging approaches may enable integration of MPI and CFR with CT visualization of anatomical atherosclerotic plaque to uniquely identify at-risk women. Radiation dose-reduction strategies, including the use of ultra-low-dose protocols involving stress-only imaging, solid-state detector SPECT, and PET, should be uniformly applied whenever possible to all women undergoing MPI. Appropriate candidate selection for stress MPI and for post-MPI indications for guideline-directed medical therapy and/or invasive coronary angiography are discussed in this statement. The critical need for randomized and comparative trial data in female patients is also emphasized.
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Literatur
1.
Zurück zum Zitat Baldassarre LA, Raman SV, Min JK, Mieres JH, Gulati M, Wenger NK, et al. Noninvasive imaging to evaluate women with stable ischemic heart disease. JACC Cardiovasc Imaging 2016;9:421-35.PubMedPubMedCentralCrossRef Baldassarre LA, Raman SV, Min JK, Mieres JH, Gulati M, Wenger NK, et al. Noninvasive imaging to evaluate women with stable ischemic heart disease. JACC Cardiovasc Imaging 2016;9:421-35.PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Bairey Merz CN, Regitz-Zagrosek V. The case for sex- and gender-specific Med. JAMA Intern Med 2014;174:1348-9.PubMedCrossRef Bairey Merz CN, Regitz-Zagrosek V. The case for sex- and gender-specific Med. JAMA Intern Med 2014;174:1348-9.PubMedCrossRef
3.
Zurück zum Zitat Taqueti VR, Di Carli MF. Radionuclide myocardial perfusion imaging for the evaluation of patients with known or suspected coronary artery disease in the era of multimodality cardiovascular imaging. Prog Cardiovasc Dis 2015;57:644-53.PubMedPubMedCentralCrossRef Taqueti VR, Di Carli MF. Radionuclide myocardial perfusion imaging for the evaluation of patients with known or suspected coronary artery disease in the era of multimodality cardiovascular imaging. Prog Cardiovasc Dis 2015;57:644-53.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Shaw LJ, Tandon S, Rosen S, Mieres JH. Evaluation of suspected ischemic heart disease in symptomatic women. Can J Cardiol 2014;30:729-37.PubMedCrossRef Shaw LJ, Tandon S, Rosen S, Mieres JH. Evaluation of suspected ischemic heart disease in symptomatic women. Can J Cardiol 2014;30:729-37.PubMedCrossRef
5.
Zurück zum Zitat Mieres JH, Gulati M, Bairey Merz N, Berman DS, Gerber TC, Hayes SN, et al. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: A consensus statement from the American Heart Association. Circulation 2014;130:350-79.PubMedCrossRef Mieres JH, Gulati M, Bairey Merz N, Berman DS, Gerber TC, Hayes SN, et al. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: A consensus statement from the American Heart Association. Circulation 2014;130:350-79.PubMedCrossRef
6.
Zurück zum Zitat Taqueti VR, Dorbala S. The role of positron emission tomography in the evaluation of myocardial ischemia in women. J Nucl Cardiol 2016;23:1008-15.PubMedCrossRef Taqueti VR, Dorbala S. The role of positron emission tomography in the evaluation of myocardial ischemia in women. J Nucl Cardiol 2016;23:1008-15.PubMedCrossRef
7.
Zurück zum Zitat Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 2012;60:e44-164.CrossRefPubMed Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 2012;60:e44-164.CrossRefPubMed
8.
Zurück zum Zitat Mieres JH, Shaw LJ, Hendel RC, Miller DD, Bonow RO, Berman DS, et al. American Society of Nuclear Cardiology consensus statement: Task force on women and coronary artery disease—the role of myocardial perfusion imaging in the clinical evaluation of coronary artery disease in women [correction]. J Nucl Cardiol 2003;10:95-101.PubMedCrossRef Mieres JH, Shaw LJ, Hendel RC, Miller DD, Bonow RO, Berman DS, et al. American Society of Nuclear Cardiology consensus statement: Task force on women and coronary artery disease—the role of myocardial perfusion imaging in the clinical evaluation of coronary artery disease in women [correction]. J Nucl Cardiol 2003;10:95-101.PubMedCrossRef
9.
Zurück zum Zitat Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, Kramer CM, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol 2014;63:380-406.PubMedCrossRef Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, Kramer CM, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol 2014;63:380-406.PubMedCrossRef
10.
Zurück zum Zitat Ouyang P, Wenger NK, Taylor D, Rich-Edwards JW, Steiner M, Shaw LJ, et al. Strategies and methods to study female-specific cardiovascular health and disease: A guide for clinical scientists. Biol Sex Differ 2016;7:19.PubMedPubMedCentralCrossRef Ouyang P, Wenger NK, Taylor D, Rich-Edwards JW, Steiner M, Shaw LJ, et al. Strategies and methods to study female-specific cardiovascular health and disease: A guide for clinical scientists. Biol Sex Differ 2016;7:19.PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation 2007;115:12. Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation 2007;115:12.
12.
Zurück zum Zitat Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: A guideline from the American Heart Association. J Am Coll Cardiol 2011;57:1404-23.PubMedPubMedCentralCrossRef Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: A guideline from the American Heart Association. J Am Coll Cardiol 2011;57:1404-23.PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Wilmot KA, O’Flaherty M, Capewell S, Ford ES, Vaccarino V. Coronary heart disease mortality declines in the United States From 1979 through 2011: Evidence for stagnation in young adults, especially women. Circulation 2015;132:997-1002.PubMedPubMedCentralCrossRef Wilmot KA, O’Flaherty M, Capewell S, Ford ES, Vaccarino V. Coronary heart disease mortality declines in the United States From 1979 through 2011: Evidence for stagnation in young adults, especially women. Circulation 2015;132:997-1002.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation 2009;119:e561-87.PubMed Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation 2009;119:e561-87.PubMed
15.
Zurück zum Zitat Shaw LJ, Mieres JH, Hendel RH, Boden WE, Gulati M, Veledar E, et al. Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease: Results from the What Is the Optimal Method for Ischemia Evaluation in Women (WOMEN) trial. Circulation 2011;124:1239-49.CrossRefPubMed Shaw LJ, Mieres JH, Hendel RH, Boden WE, Gulati M, Veledar E, et al. Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease: Results from the What Is the Optimal Method for Ischemia Evaluation in Women (WOMEN) trial. Circulation 2011;124:1239-49.CrossRefPubMed
16.
Zurück zum Zitat Woodard PK, White RD, Abbara S, Araoz PA, Cury RC, Dorbala S, et al. ACR appropriateness criteria chronic chest pain-low to intermediate probability of coronary artery disease. J Am Coll Radiol 2013;10:329-34.PubMedCrossRef Woodard PK, White RD, Abbara S, Araoz PA, Cury RC, Dorbala S, et al. ACR appropriateness criteria chronic chest pain-low to intermediate probability of coronary artery disease. J Am Coll Radiol 2013;10:329-34.PubMedCrossRef
17.
Zurück zum Zitat Berwick DM, Nolan TW, Whittington J. The triple aim: Care, health, and cost. Health Aff 2008;27:759-69.CrossRef Berwick DM, Nolan TW, Whittington J. The triple aim: Care, health, and cost. Health Aff 2008;27:759-69.CrossRef
18.
19.
Zurück zum Zitat Dolor RJ, Patel MR, Melloni C, Chatterjee R, McBroom AJ, Musty MD, et al. Noninvasive technologies for the diagnosis of coronary artery disease in women Rockville (MD): AHRQ Comparative Effectiveness Reviews 2012;Report No.: 12-EHC034-EF. Dolor RJ, Patel MR, Melloni C, Chatterjee R, McBroom AJ, Musty MD, et al. Noninvasive technologies for the diagnosis of coronary artery disease in women Rockville (MD): AHRQ Comparative Effectiveness Reviews 2012;Report No.: 12-EHC034-EF.
20.
Zurück zum Zitat Sanders GD, Patel MR, Chatterjee R, Ross AK, Bastian LA, Coeytaux RR, et al. Noninvasive technologies for the diagnosis of coronary artery disease in women: Identification of future research needs from comparative effectiveness review No 58. Rockville (MD): AHRQ comparative effectiveness reviews 2013; Report No.: 13-EHC072-EF. Sanders GD, Patel MR, Chatterjee R, Ross AK, Bastian LA, Coeytaux RR, et al. Noninvasive technologies for the diagnosis of coronary artery disease in women: Identification of future research needs from comparative effectiveness review No 58. Rockville (MD): AHRQ comparative effectiveness reviews 2013; Report No.: 13-EHC072-EF.
21.
Zurück zum Zitat Sharir T, Kang X, Germano G, Bax JJ, Shaw LJ, Gransar H, et al. Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: Gender-related differences in normal limits and outcomes. J Nucl Cardiol 2006;13:495-506.PubMedCrossRef Sharir T, Kang X, Germano G, Bax JJ, Shaw LJ, Gransar H, et al. Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: Gender-related differences in normal limits and outcomes. J Nucl Cardiol 2006;13:495-506.PubMedCrossRef
22.
Zurück zum Zitat Rivero A, Santana C, Folks RD, Esteves F, Verdes L, Esiashvili S, et al. Attenuation correction reveals gender-related differences in the normal values of transient ischemic dilation index in rest-exercise stress sestamibi myocardial perfusion imaging. J Nucl Cardiol 2006;13:338-44.PubMedCrossRef Rivero A, Santana C, Folks RD, Esteves F, Verdes L, Esiashvili S, et al. Attenuation correction reveals gender-related differences in the normal values of transient ischemic dilation index in rest-exercise stress sestamibi myocardial perfusion imaging. J Nucl Cardiol 2006;13:338-44.PubMedCrossRef
23.
Zurück zum Zitat Van Train KF, Maddahi J, Berman DS, Kiat H, Areeda J, Prigent F, et al. Quantitative analysis of tomographic stress thallium-201 myocardial scintigrams: A multicenter trial. J Nucl Med 1990;31:1168-79.PubMed Van Train KF, Maddahi J, Berman DS, Kiat H, Areeda J, Prigent F, et al. Quantitative analysis of tomographic stress thallium-201 myocardial scintigrams: A multicenter trial. J Nucl Med 1990;31:1168-79.PubMed
24.
Zurück zum Zitat Sharma P, Patel CD, Karunanithi S, Maharjan S, Malhotra A. Comparative accuracy of CT attenuation-corrected and non-attenuation-corrected SPECT myocardial perfusion imaging. Clin Nucl Med 2012;37:332-8.PubMedCrossRef Sharma P, Patel CD, Karunanithi S, Maharjan S, Malhotra A. Comparative accuracy of CT attenuation-corrected and non-attenuation-corrected SPECT myocardial perfusion imaging. Clin Nucl Med 2012;37:332-8.PubMedCrossRef
25.
Zurück zum Zitat Ficaro EP, Fessler JA, Shreve PD, Kritzman JN, Rose PA, Corbett JR. Simultaneous transmission/emission myocardial perfusion tomography. Diagnostic accuracy of attenuation-corrected 99mTc-sestamibi single-photon emission computed tomography. Circulation 1996;93:463-73.PubMedCrossRef Ficaro EP, Fessler JA, Shreve PD, Kritzman JN, Rose PA, Corbett JR. Simultaneous transmission/emission myocardial perfusion tomography. Diagnostic accuracy of attenuation-corrected 99mTc-sestamibi single-photon emission computed tomography. Circulation 1996;93:463-73.PubMedCrossRef
26.
Zurück zum Zitat Masood Y, Liu YH, Depuey G, Taillefer R, Araujo LI, Allen S, et al. Clinical validation of SPECT attenuation correction using x-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation. J Nucl Cardiol 2005;12:676-86.CrossRefPubMed Masood Y, Liu YH, Depuey G, Taillefer R, Araujo LI, Allen S, et al. Clinical validation of SPECT attenuation correction using x-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation. J Nucl Cardiol 2005;12:676-86.CrossRefPubMed
27.
Zurück zum Zitat Links JM, DePuey EG, Taillefer R, Becker LC. Attenuation correction and gating synergistically improve the diagnostic accuracy of myocardial perfusion SPECT. J Nucl Cardiol 2002;9:183-7.PubMedCrossRef Links JM, DePuey EG, Taillefer R, Becker LC. Attenuation correction and gating synergistically improve the diagnostic accuracy of myocardial perfusion SPECT. J Nucl Cardiol 2002;9:183-7.PubMedCrossRef
28.
Zurück zum Zitat Hendel RC, Berman DS, Cullom SJ, Follansbee W, Heller GV, Kiat H, et al. Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging. Circulation 1999;99:2742-9.CrossRefPubMed Hendel RC, Berman DS, Cullom SJ, Follansbee W, Heller GV, Kiat H, et al. Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging. Circulation 1999;99:2742-9.CrossRefPubMed
29.
Zurück zum Zitat Berman DS, Kang X, Nishina H, Slomka PJ, Shaw LJ, Hayes SW, et al. Diagnostic accuracy of gated Tc-99m sestamibi stress myocardial perfusion SPECT with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients. J Nucl Cardiol 2006;13:191-201.PubMedCrossRef Berman DS, Kang X, Nishina H, Slomka PJ, Shaw LJ, Hayes SW, et al. Diagnostic accuracy of gated Tc-99m sestamibi stress myocardial perfusion SPECT with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients. J Nucl Cardiol 2006;13:191-201.PubMedCrossRef
30.
Zurück zum Zitat Slomka PJ, Nishina H, Abidov A, Hayes SW, Friedman JD, Berman DS, et al. Combined quantitative supine-prone myocardial perfusion SPECT improves detection of coronary artery disease and normalcy rates in women. J Nucl Cardiol 2007;14:44-52.PubMedCrossRef Slomka PJ, Nishina H, Abidov A, Hayes SW, Friedman JD, Berman DS, et al. Combined quantitative supine-prone myocardial perfusion SPECT improves detection of coronary artery disease and normalcy rates in women. J Nucl Cardiol 2007;14:44-52.PubMedCrossRef
31.
Zurück zum Zitat Ben-Haim S, Almukhailed O, Neill J, Slomka P, Allie R, Shiti D, et al. Clinical value of supine and upright myocardial perfusion imaging in obese patients using the D-SPECT camera. J Nucl Cardiol 2014;21:478-85.PubMedCrossRef Ben-Haim S, Almukhailed O, Neill J, Slomka P, Allie R, Shiti D, et al. Clinical value of supine and upright myocardial perfusion imaging in obese patients using the D-SPECT camera. J Nucl Cardiol 2014;21:478-85.PubMedCrossRef
32.
Zurück zum Zitat Grossman GB, Garcia EV, Bateman TM, Heller GV, Johnson LL, Folks RD, et al. Quantitative Tc-99m sestamibi attenuation-corrected SPECT: Development and multicenter trial validation of myocardial perfusion stress gender-independent normal database in an obese population. J Nucl Cardiol 2004;11:263-72.PubMedCrossRef Grossman GB, Garcia EV, Bateman TM, Heller GV, Johnson LL, Folks RD, et al. Quantitative Tc-99m sestamibi attenuation-corrected SPECT: Development and multicenter trial validation of myocardial perfusion stress gender-independent normal database in an obese population. J Nucl Cardiol 2004;11:263-72.PubMedCrossRef
33.
Zurück zum Zitat Heller GV, Bateman TM, Johnson LL, Cullom SJ, Case JA, Galt JR, et al. Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging. J Nucl Cardiol 2004;11:273-81.PubMedCrossRef Heller GV, Bateman TM, Johnson LL, Cullom SJ, Case JA, Galt JR, et al. Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging. J Nucl Cardiol 2004;11:273-81.PubMedCrossRef
34.
Zurück zum Zitat Pepine CJ, Anderson RD, Sharaf BL, Reis SE, Smith KM, Handberg EM, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women’s Ischemia Syndrome Evaluation) study. J Am Coll Cardiol 2010;55:2825-32.PubMedPubMedCentralCrossRef Pepine CJ, Anderson RD, Sharaf BL, Reis SE, Smith KM, Handberg EM, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women’s Ischemia Syndrome Evaluation) study. J Am Coll Cardiol 2010;55:2825-32.PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Taqueti V, Shaw LJ, Murthy VL, Shah NR, Foster CR, Hainer J, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with impaired coronary flow reserve from diffuse versus obstructive coronary artery disease. Circulation 2017;135:566-77.PubMedCrossRef Taqueti V, Shaw LJ, Murthy VL, Shah NR, Foster CR, Hainer J, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with impaired coronary flow reserve from diffuse versus obstructive coronary artery disease. Circulation 2017;135:566-77.PubMedCrossRef
36.
Zurück zum Zitat Kohli P, Gulati M. Exercise stress testing in women: Going back to the basics. Circulation 2010;122:2570-80.PubMedCrossRef Kohli P, Gulati M. Exercise stress testing in women: Going back to the basics. Circulation 2010;122:2570-80.PubMedCrossRef
37.
Zurück zum Zitat Grzybowski A, Puchalski W, Zieba B, Gruchala M, Fijalkowski M, Storoniak K, et al. How to improve noninvasive coronary artery disease diagnostics in premenopausal women? The influence of menstrual cycle on ST depression, left ventricle contractility, and chest pain observed during exercise echocardiography in women with angina and normal coronary angiogram. Am Heart J 2008;156:964 e1-5.CrossRef Grzybowski A, Puchalski W, Zieba B, Gruchala M, Fijalkowski M, Storoniak K, et al. How to improve noninvasive coronary artery disease diagnostics in premenopausal women? The influence of menstrual cycle on ST depression, left ventricle contractility, and chest pain observed during exercise echocardiography in women with angina and normal coronary angiogram. Am Heart J 2008;156:964 e1-5.CrossRef
38.
Zurück zum Zitat Morise AP, Beto R. The specificity of exercise electrocardiography in women grouped by estrogen status. Int J Cardiol 1997;60:55-65.PubMedCrossRef Morise AP, Beto R. The specificity of exercise electrocardiography in women grouped by estrogen status. Int J Cardiol 1997;60:55-65.PubMedCrossRef
39.
Zurück zum Zitat Barolsky SM, Gilbert CA, Faruqui A, Nutter DO, Schlant RC. Differences in electrocardiographic response to exercise of women and men: A non-Bayesian factor. Circulation 1979;60:1021-7.PubMedCrossRef Barolsky SM, Gilbert CA, Faruqui A, Nutter DO, Schlant RC. Differences in electrocardiographic response to exercise of women and men: A non-Bayesian factor. Circulation 1979;60:1021-7.PubMedCrossRef
40.
Zurück zum Zitat Mora S, Redberg RF, Cui Y, Whiteman MK, Flaws JA, Sharrett AR, et al. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: A 20-year follow-up of the lipid research clinics prevalence study. JAMA 2003;290:1600-7.PubMedCrossRef Mora S, Redberg RF, Cui Y, Whiteman MK, Flaws JA, Sharrett AR, et al. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: A 20-year follow-up of the lipid research clinics prevalence study. JAMA 2003;290:1600-7.PubMedCrossRef
41.
Zurück zum Zitat Kwok Y, Kim C, Grady D, Segal M, Redberg R. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 1999;83:660-6.PubMedCrossRef Kwok Y, Kim C, Grady D, Segal M, Redberg R. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 1999;83:660-6.PubMedCrossRef
42.
Zurück zum Zitat Abbott BG, Afshar M, Berger AK, Wackers FJ. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. J Nucl Cardiol 2003;10:9-16.PubMedCrossRef Abbott BG, Afshar M, Berger AK, Wackers FJ. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. J Nucl Cardiol 2003;10:9-16.PubMedCrossRef
43.
Zurück zum Zitat Klodas E, Miller TD, Christian TF, Hodge DO, Gibbons RJ. Prognostic significance of ischemic electrocardiographic changes during vasodilator stress testing in patients with normal SPECT images. J Nucl Cardiol 2003;10:4-8.PubMedCrossRef Klodas E, Miller TD, Christian TF, Hodge DO, Gibbons RJ. Prognostic significance of ischemic electrocardiographic changes during vasodilator stress testing in patients with normal SPECT images. J Nucl Cardiol 2003;10:4-8.PubMedCrossRef
44.
Zurück zum Zitat Amanullah AM, Kiat H, Friedman JD, Berman DS. Adenosine technetium-99m sestamibi myocardial perfusion SPECT in women: Diagnostic efficacy in detection of coronary artery disease. J Am Coll Cardiol 1996;27:803-9.PubMedCrossRef Amanullah AM, Kiat H, Friedman JD, Berman DS. Adenosine technetium-99m sestamibi myocardial perfusion SPECT in women: Diagnostic efficacy in detection of coronary artery disease. J Am Coll Cardiol 1996;27:803-9.PubMedCrossRef
45.
Zurück zum Zitat Travin MI, Katz MS, Moulton AW, Miele NJ, Sharaf BL, Johnson LL. Accuracy of dipyridamole SPECT imaging in identifying individual coronary stenoses and multivessel disease in women versus men. J Nucl Cardiol 2000;7:213-20.PubMedCrossRef Travin MI, Katz MS, Moulton AW, Miele NJ, Sharaf BL, Johnson LL. Accuracy of dipyridamole SPECT imaging in identifying individual coronary stenoses and multivessel disease in women versus men. J Nucl Cardiol 2000;7:213-20.PubMedCrossRef
46.
Zurück zum Zitat Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Investigators A-MT. Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results. JACC Cardiovasc Imaging 2008;1:307-16.CrossRef Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Investigators A-MT. Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging integrated ADVANCE-MPI trial results. JACC Cardiovasc Imaging 2008;1:307-16.CrossRef
47.
Zurück zum Zitat Santana-Boado C, Candell-Riera J, Castell-Conesa J, Aguade-Bruix S, Garcia-Burillo A, Canela T, et al. Diagnostic accuracy of technetium-99m-MIBI myocardial SPECT in women and men. J Nucl Med 1998;39:751-5.PubMed Santana-Boado C, Candell-Riera J, Castell-Conesa J, Aguade-Bruix S, Garcia-Burillo A, Canela T, et al. Diagnostic accuracy of technetium-99m-MIBI myocardial SPECT in women and men. J Nucl Med 1998;39:751-5.PubMed
48.
Zurück zum Zitat Taillefer R, DePuey EG, Udelson JE, Beller GA, Latour Y, Reeves F. Comparative diagnostic accuracy of Tl-201 and Tc-99m sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women. J Am Coll Cardiol 1997;29:69-77.PubMedCrossRef Taillefer R, DePuey EG, Udelson JE, Beller GA, Latour Y, Reeves F. Comparative diagnostic accuracy of Tl-201 and Tc-99m sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women. J Am Coll Cardiol 1997;29:69-77.PubMedCrossRef
49.
Zurück zum Zitat Chae SC, Heo J, Iskandrian AS, Wasserleben V, Cave V. Identification of extensive coronary artery disease in women by exercise single-photon emission computed tomographic (SPECT) thallium imaging. J Am Coll Cardiol 1993;21:1305-11.PubMedCrossRef Chae SC, Heo J, Iskandrian AS, Wasserleben V, Cave V. Identification of extensive coronary artery disease in women by exercise single-photon emission computed tomographic (SPECT) thallium imaging. J Am Coll Cardiol 1993;21:1305-11.PubMedCrossRef
50.
Zurück zum Zitat Iskandrian AE, Heo J, Nallamothu N. Detection of coronary artery disease in women with use of stress single-photon emission computed tomography myocardial perfusion imaging. J Nucl Cardiol 1997;4:329-35.PubMedCrossRef Iskandrian AE, Heo J, Nallamothu N. Detection of coronary artery disease in women with use of stress single-photon emission computed tomography myocardial perfusion imaging. J Nucl Cardiol 1997;4:329-35.PubMedCrossRef
51.
Zurück zum Zitat Mullani NA, Caras D, Ahn C, Lundberg G, Page D, Kleinman D, et al. Fewer women than men have positive SPECT and PET cardiac findings among patients with no history of heart disease. J Nucl Med 2000;41:263-8.PubMed Mullani NA, Caras D, Ahn C, Lundberg G, Page D, Kleinman D, et al. Fewer women than men have positive SPECT and PET cardiac findings among patients with no history of heart disease. J Nucl Med 2000;41:263-8.PubMed
52.
Zurück zum Zitat Hansen CL, Crabbe D, Rubin S. Lower diagnostic accuracy of thallium-201 SPECT myocardial perfusion imaging in women: An effect of smaller chamber size. J Am Coll Cardiol 1996;28:1214-9.PubMedCrossRef Hansen CL, Crabbe D, Rubin S. Lower diagnostic accuracy of thallium-201 SPECT myocardial perfusion imaging in women: An effect of smaller chamber size. J Am Coll Cardiol 1996;28:1214-9.PubMedCrossRef
53.
Zurück zum Zitat Hachamovitch R, Berman DS, Kiat H, Bairey CN, Cohen I, Cabico A, et al. Effective risk stratification using exercise myocardial perfusion SPECT in women: Gender-related differences in prognostic nuclear testing. J Am Coll Cardiol 1996;28:34-44.PubMedCrossRef Hachamovitch R, Berman DS, Kiat H, Bairey CN, Cohen I, Cabico A, et al. Effective risk stratification using exercise myocardial perfusion SPECT in women: Gender-related differences in prognostic nuclear testing. J Am Coll Cardiol 1996;28:34-44.PubMedCrossRef
54.
Zurück zum Zitat Santos MT, Parker MW, Heller GV. Evaluating gender differences in prognosis following SPECT myocardial perfusion imaging among patients with diabetes and known or suspected coronary disease in the modern era. J Nucl Cardiol 2013;20:1021-9.PubMedCrossRef Santos MT, Parker MW, Heller GV. Evaluating gender differences in prognosis following SPECT myocardial perfusion imaging among patients with diabetes and known or suspected coronary disease in the modern era. J Nucl Cardiol 2013;20:1021-9.PubMedCrossRef
55.
Zurück zum Zitat Pancholy SB, Fattah AA, Kamal AM, Ghods M, Heo J, Iskandrian AS. Independent and incremental prognostic value of exercise thallium single-photon emission computed tomographic imaging in women. J Nucl Cardiol 1995;2:110-6.PubMed Pancholy SB, Fattah AA, Kamal AM, Ghods M, Heo J, Iskandrian AS. Independent and incremental prognostic value of exercise thallium single-photon emission computed tomographic imaging in women. J Nucl Cardiol 1995;2:110-6.PubMed
56.
Zurück zum Zitat Marwick TH, Shaw LJ, Lauer MS, Kesler K, Hachamovitch R, Heller GV, et al. The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease. Economics of noninvasive diagnosis (END) study group. Am J Med 1999;106:172-8.PubMedCrossRef Marwick TH, Shaw LJ, Lauer MS, Kesler K, Hachamovitch R, Heller GV, et al. The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease. Economics of noninvasive diagnosis (END) study group. Am J Med 1999;106:172-8.PubMedCrossRef
57.
Zurück zum Zitat Metz LD, Beattie M, Hom R, Redberg RF, Grady D, Fleischmann KE. The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: A meta-analysis. J Am Coll Cardiol 2007;49:227-37.PubMedCrossRef Metz LD, Beattie M, Hom R, Redberg RF, Grady D, Fleischmann KE. The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: A meta-analysis. J Am Coll Cardiol 2007;49:227-37.PubMedCrossRef
58.
Zurück zum Zitat Shaw LJ, Hage FG, Berman DS, Hachamovitch R, Iskandrian A. Prognosis in the era of comparative effectiveness research: Where is nuclear cardiology now and where should it be? J Nucl Cardiol 2012;19:1026-43.PubMedCrossRef Shaw LJ, Hage FG, Berman DS, Hachamovitch R, Iskandrian A. Prognosis in the era of comparative effectiveness research: Where is nuclear cardiology now and where should it be? J Nucl Cardiol 2012;19:1026-43.PubMedCrossRef
59.
Zurück zum Zitat Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 1999;100:1035-42.CrossRefPubMed Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 1999;100:1035-42.CrossRefPubMed
60.
Zurück zum Zitat Valeti US, Miller TD, Hodge DO, Gibbons RJ. Exercise single-photon emission computed tomography provides effective risk stratification of elderly men and elderly women. Circulation 2005;111:1771-6.PubMedCrossRef Valeti US, Miller TD, Hodge DO, Gibbons RJ. Exercise single-photon emission computed tomography provides effective risk stratification of elderly men and elderly women. Circulation 2005;111:1771-6.PubMedCrossRef
61.
Zurück zum Zitat Cerci MS, Cerci JJ, Cerci RJ, Pereira Neto CC, Trindade E, Delbeke D, et al. Myocardial perfusion imaging is a strong predictor of death in women. JACC Cardiovasc Imaging. 2011;4:880-8PubMedCrossRef Cerci MS, Cerci JJ, Cerci RJ, Pereira Neto CC, Trindade E, Delbeke D, et al. Myocardial perfusion imaging is a strong predictor of death in women. JACC Cardiovasc Imaging. 2011;4:880-8PubMedCrossRef
62.
Zurück zum Zitat Chang SM, Nabi F, Xu J, Raza U, Mahmarian JJ. Normal stress-only versus standard stress/rest myocardial perfusion imaging: Similar patient mortality with reduced radiation exposure. J Am Coll Cardiol 2010;55:221-30.PubMedCrossRef Chang SM, Nabi F, Xu J, Raza U, Mahmarian JJ. Normal stress-only versus standard stress/rest myocardial perfusion imaging: Similar patient mortality with reduced radiation exposure. J Am Coll Cardiol 2010;55:221-30.PubMedCrossRef
63.
Zurück zum Zitat Duvall WL, Wijetunga MN, Klein TM, Razzouk L, Godbold J, Croft LB, et al. The prognosis of a normal stress-only Tc-99m myocardial perfusion imaging study. J Nucl Cardiol 2010;17:370-7.PubMedCrossRef Duvall WL, Wijetunga MN, Klein TM, Razzouk L, Godbold J, Croft LB, et al. The prognosis of a normal stress-only Tc-99m myocardial perfusion imaging study. J Nucl Cardiol 2010;17:370-7.PubMedCrossRef
64.
Zurück zum Zitat Chang SM, Nabi F, Xu J, Peterson LE, Achari A, Pratt CM, et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol 2009;54:1872-82.CrossRefPubMed Chang SM, Nabi F, Xu J, Peterson LE, Achari A, Pratt CM, et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol 2009;54:1872-82.CrossRefPubMed
65.
Zurück zum Zitat He ZX, Hedrick TD, Pratt CM, Verani MS, Aquino V, Roberts R, et al. Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation 2000;101:244-51.PubMedCrossRef He ZX, Hedrick TD, Pratt CM, Verani MS, Aquino V, Roberts R, et al. Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation 2000;101:244-51.PubMedCrossRef
66.
Zurück zum Zitat Ghadri JR, Fiechter M, Veraguth K, Gebhard C, Pazhenkottil AP, Fuchs TA, et al. Coronary calcium score as an adjunct to nuclear myocardial perfusion imaging for risk stratification before noncardiac surgery. J Nucl Med 2012;53:1081-6.PubMedCrossRef Ghadri JR, Fiechter M, Veraguth K, Gebhard C, Pazhenkottil AP, Fuchs TA, et al. Coronary calcium score as an adjunct to nuclear myocardial perfusion imaging for risk stratification before noncardiac surgery. J Nucl Med 2012;53:1081-6.PubMedCrossRef
67.
Zurück zum Zitat Anand DV, Lim E, Hopkins D, Corder R, Shaw LJ, Sharp P, et al. Risk stratification in uncomplicated type 2 diabetes: Prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 2006;27:713-21.PubMedCrossRef Anand DV, Lim E, Hopkins D, Corder R, Shaw LJ, Sharp P, et al. Risk stratification in uncomplicated type 2 diabetes: Prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 2006;27:713-21.PubMedCrossRef
68.
Zurück zum Zitat Berman DS, Wong ND, Gransar H, Miranda-Peats R, Dahlbeck J, Hayes SW, et al. Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Cardiol 2004;44:923-30.CrossRefPubMed Berman DS, Wong ND, Gransar H, Miranda-Peats R, Dahlbeck J, Hayes SW, et al. Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Cardiol 2004;44:923-30.CrossRefPubMed
69.
Zurück zum Zitat Rozanski A, Gransar H, Wong ND, Shaw LJ, Miranda-Peats R, Polk D, et al. Clinical outcomes after both coronary calcium scanning and exercise myocardial perfusion scintigraphy. J Am Coll Cardiol 2007;49:1352-61.PubMedCrossRef Rozanski A, Gransar H, Wong ND, Shaw LJ, Miranda-Peats R, Polk D, et al. Clinical outcomes after both coronary calcium scanning and exercise myocardial perfusion scintigraphy. J Am Coll Cardiol 2007;49:1352-61.PubMedCrossRef
70.
Zurück zum Zitat Ramakrishna G, Miller TD, Breen JF, Araoz PA, Hodge DO, Gibbons RJ. Relationship and prognostic value of coronary artery calcification by electron beam computed tomography to stress-induced ischemia by single photon emission computed tomography. Am Heart J 2007;153:807-14.PubMedCrossRef Ramakrishna G, Miller TD, Breen JF, Araoz PA, Hodge DO, Gibbons RJ. Relationship and prognostic value of coronary artery calcification by electron beam computed tomography to stress-induced ischemia by single photon emission computed tomography. Am Heart J 2007;153:807-14.PubMedCrossRef
71.
Zurück zum Zitat Einstein AJ, Johnson LL, Bokhari S, Son J, Thompson RC, Bateman TM, et al. Agreement of visual estimation of coronary artery calcium from low-dose CT attenuation correction scans in hybrid PET/CT and SPECT/CT with standard Agatston score. J Am Coll Cardiol 2010;56:1914-21.PubMedPubMedCentralCrossRef Einstein AJ, Johnson LL, Bokhari S, Son J, Thompson RC, Bateman TM, et al. Agreement of visual estimation of coronary artery calcium from low-dose CT attenuation correction scans in hybrid PET/CT and SPECT/CT with standard Agatston score. J Am Coll Cardiol 2010;56:1914-21.PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Lubbers M, Dedic A, Coenen A, Galema T, Akkerhuis J, Bruning T, et al. Calcium imaging and selective computed tomography angiography in comparison to functional testing for suspected coronary artery disease: The multicentre, randomized CRESCENT trial. Eur Heart J 2016;37:1232-43.PubMedCrossRef Lubbers M, Dedic A, Coenen A, Galema T, Akkerhuis J, Bruning T, et al. Calcium imaging and selective computed tomography angiography in comparison to functional testing for suspected coronary artery disease: The multicentre, randomized CRESCENT trial. Eur Heart J 2016;37:1232-43.PubMedCrossRef
73.
Zurück zum Zitat Greenland P, Bonow RO. How low-risk is a coronary calcium score of zero? Circulation 2008;117:1627-9.PubMedCrossRef Greenland P, Bonow RO. How low-risk is a coronary calcium score of zero? Circulation 2008;117:1627-9.PubMedCrossRef
74.
Zurück zum Zitat Kelkar AA, Schultz WM, Khosa F, Schulman-Marcus J, O’Hartaigh BW, Gransar H, et al. Long-term prognosis after coronary artery calcium scoring among low-intermediate risk women and men. Circ Cardiovasc Imaging 2016;9:e003742.PubMedCrossRef Kelkar AA, Schultz WM, Khosa F, Schulman-Marcus J, O’Hartaigh BW, Gransar H, et al. Long-term prognosis after coronary artery calcium scoring among low-intermediate risk women and men. Circ Cardiovasc Imaging 2016;9:e003742.PubMedCrossRef
75.
Zurück zum Zitat Gaemperli O, Husmann L, Schepis T, Koepfli P, Valenta I, Jenni W, et al. Coronary CT angiography and myocardial perfusion imaging to detect flow-limiting stenoses: A potential gatekeeper for coronary revascularization? Eur Heart J 2009;30:2921-9.PubMedCrossRef Gaemperli O, Husmann L, Schepis T, Koepfli P, Valenta I, Jenni W, et al. Coronary CT angiography and myocardial perfusion imaging to detect flow-limiting stenoses: A potential gatekeeper for coronary revascularization? Eur Heart J 2009;30:2921-9.PubMedCrossRef
76.
Zurück zum Zitat Schuijf JD, Wijns W, Jukema JW, Atsma DE, de Roos A, Lamb HJ, et al. Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging. J Am Coll Cardiol 2006;48:2508-14.CrossRefPubMed Schuijf JD, Wijns W, Jukema JW, Atsma DE, de Roos A, Lamb HJ, et al. Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging. J Am Coll Cardiol 2006;48:2508-14.CrossRefPubMed
77.
Zurück zum Zitat Gaemperli O, Schepis T, Valenta I, Koepfli P, Husmann L, Scheffel H, et al. Functionally relevant coronary artery disease: Comparison of 64-section CT angiography with myocardial perfusion SPECT. Radiology 2008;248:414-23.PubMedCrossRef Gaemperli O, Schepis T, Valenta I, Koepfli P, Husmann L, Scheffel H, et al. Functionally relevant coronary artery disease: Comparison of 64-section CT angiography with myocardial perfusion SPECT. Radiology 2008;248:414-23.PubMedCrossRef
78.
Zurück zum Zitat Husmann L, Herzog BA, Gaemperli O, Tatsugami F, Burkhard N, Valenta I, et al. Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: Comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Heart J 2009;30:600-7.PubMedCrossRef Husmann L, Herzog BA, Gaemperli O, Tatsugami F, Burkhard N, Valenta I, et al. Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: Comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Heart J 2009;30:600-7.PubMedCrossRef
79.
Zurück zum Zitat Pazhenkottil AP, Nkoulou RN, Ghadri JR, Herzog BA, Buechel RR, Kuest SM, et al. Prognostic value of cardiac hybrid imaging integrating single-photon emission computed tomography with coronary computed tomography angiography. Eur Heart J 2011;32:1465-71.PubMedCrossRef Pazhenkottil AP, Nkoulou RN, Ghadri JR, Herzog BA, Buechel RR, Kuest SM, et al. Prognostic value of cardiac hybrid imaging integrating single-photon emission computed tomography with coronary computed tomography angiography. Eur Heart J 2011;32:1465-71.PubMedCrossRef
80.
Zurück zum Zitat Dorbala S, Blankstein R, Skali H, Park MA, Fantony J, Mauceri C, et al. Approaches to reducing radiation dose from radionuclide myocardial perfusion imaging. J Nucl Med 2015;56:592-9.CrossRefPubMed Dorbala S, Blankstein R, Skali H, Park MA, Fantony J, Mauceri C, et al. Approaches to reducing radiation dose from radionuclide myocardial perfusion imaging. J Nucl Med 2015;56:592-9.CrossRefPubMed
81.
Zurück zum Zitat Ben-Haim S, Murthy VL, Breault C, Allie R, Sitek A, Roth N, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: A feasibility study. J Nucl Med 2013;54:873-9.PubMedCrossRef Ben-Haim S, Murthy VL, Breault C, Allie R, Sitek A, Roth N, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: A feasibility study. J Nucl Med 2013;54:873-9.PubMedCrossRef
82.
Zurück zum Zitat Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: Comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol 2013;20:763-73.PubMedCrossRef Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: Comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol 2013;20:763-73.PubMedCrossRef
83.
Zurück zum Zitat Chowdhury FU, Vaidyanathan S, Bould M, Marsh J, Trickett C, Dodds K, et al. Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: Prognostic value and diagnostic accuracy in a ‘real-world’ nuclear cardiology service. Eur Heart J Cardiovasc Imaging 2014;15:275-83.PubMedCrossRef Chowdhury FU, Vaidyanathan S, Bould M, Marsh J, Trickett C, Dodds K, et al. Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: Prognostic value and diagnostic accuracy in a ‘real-world’ nuclear cardiology service. Eur Heart J Cardiovasc Imaging 2014;15:275-83.PubMedCrossRef
84.
Zurück zum Zitat Gimelli A, Bottai M, Quaranta A, Giorgetti A, Genovesi D, Marzullo P. Gender differences in the evaluation of coronary artery disease with a cadmium-zinc telluride camera. Eur J Nucl Med Mol Imaging 2013;40:1542-8.PubMedCrossRef Gimelli A, Bottai M, Quaranta A, Giorgetti A, Genovesi D, Marzullo P. Gender differences in the evaluation of coronary artery disease with a cadmium-zinc telluride camera. Eur J Nucl Med Mol Imaging 2013;40:1542-8.PubMedCrossRef
85.
86.
Zurück zum Zitat Di Carli MF, Dorbala S, Meserve J, El Fakhri G, Sitek A, Moore SC. Clinical myocardial perfusion PET/CT. J Nucl Med 2007;48:783-93.PubMedCrossRef Di Carli MF, Dorbala S, Meserve J, El Fakhri G, Sitek A, Moore SC. Clinical myocardial perfusion PET/CT. J Nucl Med 2007;48:783-93.PubMedCrossRef
87.
Zurück zum Zitat Parker MW, Iskandar A, Limone B, Perugini A, Kim H, Jones C, et al. Diagnostic accuracy of cardiac positron emission tomography versus single photon emission computed tomography for coronary artery disease: A bivariate meta-analysis. Circ Cardiovasc Imaging 2012;5:700-7.CrossRefPubMed Parker MW, Iskandar A, Limone B, Perugini A, Kim H, Jones C, et al. Diagnostic accuracy of cardiac positron emission tomography versus single photon emission computed tomography for coronary artery disease: A bivariate meta-analysis. Circ Cardiovasc Imaging 2012;5:700-7.CrossRefPubMed
88.
Zurück zum Zitat Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: A systematic review and meta-analysis. J Am Coll Cardiol 2012;60:1828-37.PubMedCrossRef Mc Ardle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: A systematic review and meta-analysis. J Am Coll Cardiol 2012;60:1828-37.PubMedCrossRef
89.
Zurück zum Zitat Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights from the NHLBI-sponsored women’s ischemia syndrome evaluation (WISE) study: Part II: Gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol 2006;47:S21-9.PubMedCrossRef Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights from the NHLBI-sponsored women’s ischemia syndrome evaluation (WISE) study: Part II: Gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol 2006;47:S21-9.PubMedCrossRef
90.
Zurück zum Zitat Shaw LJ, Bairey Merz CN, Pepine CJ, Reis SE, Bittner V, Kelsey SF, et al. Insights from the NHLBI-sponsored women’s ischemia syndrome evaluation (WISE) study: Part I: GENDER differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol 2006;47:S4-20.PubMedCrossRef Shaw LJ, Bairey Merz CN, Pepine CJ, Reis SE, Bittner V, Kelsey SF, et al. Insights from the NHLBI-sponsored women’s ischemia syndrome evaluation (WISE) study: Part I: GENDER differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol 2006;47:S4-20.PubMedCrossRef
91.
Zurück zum Zitat Dorbala S, Di Carli MF, Beanlands RS, Merhige ME, Williams BA, Veledar E, et al. Prognostic value of stress myocardial perfusion positron emission tomography: Results from a multicenter observational registry. J Am Coll Cardiol 2013;61:176-84.PubMedCrossRef Dorbala S, Di Carli MF, Beanlands RS, Merhige ME, Williams BA, Veledar E, et al. Prognostic value of stress myocardial perfusion positron emission tomography: Results from a multicenter observational registry. J Am Coll Cardiol 2013;61:176-84.PubMedCrossRef
92.
Zurück zum Zitat Dorbala S, Hachamovitch R, Curillova Z, Thomas D, Vangala D, Kwong RY, et al. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF. JACC Cardiovasc Imaging 2009;2:846-54.PubMedPubMedCentralCrossRef Dorbala S, Hachamovitch R, Curillova Z, Thomas D, Vangala D, Kwong RY, et al. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF. JACC Cardiovasc Imaging 2009;2:846-54.PubMedPubMedCentralCrossRef
93.
Zurück zum Zitat Lertsburapa K, Ahlberg AW, Bateman TM, Katten D, Volker L, Cullom SJ, et al. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease. J Nucl Cardiol 2008;15:745-53.PubMedCrossRef Lertsburapa K, Ahlberg AW, Bateman TM, Katten D, Volker L, Cullom SJ, et al. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease. J Nucl Cardiol 2008;15:745-53.PubMedCrossRef
94.
Zurück zum Zitat Marwick TH, Shan K, Patel S, Go RT, Lauer MS. Incremental value of rubidium-82 positron emission tomography for prognostic assessment of known or suspected coronary artery disease. Am J Cardiol 1997;80:865-70.PubMedCrossRef Marwick TH, Shan K, Patel S, Go RT, Lauer MS. Incremental value of rubidium-82 positron emission tomography for prognostic assessment of known or suspected coronary artery disease. Am J Cardiol 1997;80:865-70.PubMedCrossRef
95.
Zurück zum Zitat Yoshinaga K, Chow BJ, Williams K, Chen L, deKemp RA, Garrard L, et al. What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 2006;48:1029-39.PubMedCrossRef Yoshinaga K, Chow BJ, Williams K, Chen L, deKemp RA, Garrard L, et al. What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 2006;48:1029-39.PubMedCrossRef
96.
Zurück zum Zitat Van Tosh A, Supino PG, Nichols KJ, Garza D, Horowitz SF, Reichek N. Prognosis of a normal positron emission tomography 82Rb myocardial perfusion imaging study in women with no history of coronary disease. Cardiology 2010;117:301-6.PubMedCrossRef Van Tosh A, Supino PG, Nichols KJ, Garza D, Horowitz SF, Reichek N. Prognosis of a normal positron emission tomography 82Rb myocardial perfusion imaging study in women with no history of coronary disease. Cardiology 2010;117:301-6.PubMedCrossRef
97.
Zurück zum Zitat Kay J, Dorbala S, Goyal A, Fazel R, Di Carli MF, Einstein AJ, et al. Influence of sex on risk stratification with stress myocardial perfusion Rb-82 positron emission tomography: Results from the PET (Positron Emission Tomography) Prognosis Multicenter Registry. J Am Coll Cardiol 2013;62:1866-76.PubMedCrossRef Kay J, Dorbala S, Goyal A, Fazel R, Di Carli MF, Einstein AJ, et al. Influence of sex on risk stratification with stress myocardial perfusion Rb-82 positron emission tomography: Results from the PET (Positron Emission Tomography) Prognosis Multicenter Registry. J Am Coll Cardiol 2013;62:1866-76.PubMedCrossRef
98.
Zurück zum Zitat Dorbala S, Vangala D, Sampson U, Limaye A, Kwong R, Di Carli MF. Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med 2007;48:349-58.PubMed Dorbala S, Vangala D, Sampson U, Limaye A, Kwong R, Di Carli MF. Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med 2007;48:349-58.PubMed
100.
Zurück zum Zitat Gulati M, Cooper-DeHoff RM, McClure C, Johnson BD, Shaw LJ, Handberg EM, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: A report from the Women’s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. Arch Intern Med 2009;169:843-50.PubMedPubMedCentralCrossRef Gulati M, Cooper-DeHoff RM, McClure C, Johnson BD, Shaw LJ, Handberg EM, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: A report from the Women’s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. Arch Intern Med 2009;169:843-50.PubMedPubMedCentralCrossRef
101.
Zurück zum Zitat Pepine CJ, Ferdinand KC, Shaw LJ, Light-McGroary KA, Shah RU, Gulati M, et al. Emergence of nonobstructive coronary artery disease: A woman’s problem and need for change in definition on angiography. J Am Coll Cardiol 2015;66:1918-33.PubMedPubMedCentralCrossRef Pepine CJ, Ferdinand KC, Shaw LJ, Light-McGroary KA, Shah RU, Gulati M, et al. Emergence of nonobstructive coronary artery disease: A woman’s problem and need for change in definition on angiography. J Am Coll Cardiol 2015;66:1918-33.PubMedPubMedCentralCrossRef
102.
Zurück zum Zitat von Mering GO, Arant CB, Wessel TR, McGorray SP, Bairey Merz CN, Sharaf BL, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: Results from the national heart, lung, and blood institute-sponsored women’s ischemia syndrome evaluation (WISE). Circulation 2004;109:722-5.CrossRef von Mering GO, Arant CB, Wessel TR, McGorray SP, Bairey Merz CN, Sharaf BL, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: Results from the national heart, lung, and blood institute-sponsored women’s ischemia syndrome evaluation (WISE). Circulation 2004;109:722-5.CrossRef
103.
104.
Zurück zum Zitat Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 2011;124:2215-24.PubMedPubMedCentralCrossRef Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 2011;124:2215-24.PubMedPubMedCentralCrossRef
105.
Zurück zum Zitat Ziadi MC, Dekemp RA, Williams KA, Guo A, Chow BJ, Renaud JM, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol 2011;58:740-8.PubMedCrossRef Ziadi MC, Dekemp RA, Williams KA, Guo A, Chow BJ, Renaud JM, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol 2011;58:740-8.PubMedCrossRef
106.
Zurück zum Zitat Fukushima K, Javadi MS, Higuchi T, Lautamaki R, Merrill J, Nekolla SG, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med 2011;52:726-32.PubMedCrossRef Fukushima K, Javadi MS, Higuchi T, Lautamaki R, Merrill J, Nekolla SG, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med 2011;52:726-32.PubMedCrossRef
107.
Zurück zum Zitat Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, et al. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol 2009;54:150-6.PubMedCrossRef Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, et al. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol 2009;54:150-6.PubMedCrossRef
108.
Zurück zum Zitat Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014;55:248-55.PubMedCrossRef Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014;55:248-55.PubMedCrossRef
109.
Zurück zum Zitat Taqueti VR, Di Carli MF. Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease. Curr Opin Cardiol 2016;31:662-9.PubMedCrossRef Taqueti VR, Di Carli MF. Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease. Curr Opin Cardiol 2016;31:662-9.PubMedCrossRef
110.
Zurück zum Zitat Murthy VL, Lee BC, Sitek A, Naya M, Moody J, Polavarapu V, et al. Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with 82Rb PET. J Nucl Med 2014;55:1952-8.PubMedCrossRef Murthy VL, Lee BC, Sitek A, Naya M, Moody J, Polavarapu V, et al. Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with 82Rb PET. J Nucl Med 2014;55:1952-8.PubMedCrossRef
111.
Zurück zum Zitat Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 2015;131:19-27.PubMedCrossRef Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 2015;131:19-27.PubMedCrossRef
112.
Zurück zum Zitat Li S, Fonarow GC, Mukamal KJ, Liang L, Schulte PJ, Smith EE, et al. Sex and race/ethnicity-related disparities in care and outcomes after hospitalization for coronary artery disease among older adults. Circ Cardiovasc Qual Outcomes 2016;9:S36-44.PubMedCrossRef Li S, Fonarow GC, Mukamal KJ, Liang L, Schulte PJ, Smith EE, et al. Sex and race/ethnicity-related disparities in care and outcomes after hospitalization for coronary artery disease among older adults. Circ Cardiovasc Qual Outcomes 2016;9:S36-44.PubMedCrossRef
113.
Zurück zum Zitat Smilowitz NR, Sampson BA, Abrecht CR, Siegfried JS, Hochman JS, Reynolds HR. Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: An autopsy study. Am Heart J 2011;161:681-8.PubMedCrossRef Smilowitz NR, Sampson BA, Abrecht CR, Siegfried JS, Hochman JS, Reynolds HR. Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: An autopsy study. Am Heart J 2011;161:681-8.PubMedCrossRef
114.
Zurück zum Zitat Murthy VL, Naya M, Taqueti VR, Foster CR, Gaber M, Hainer J, et al. Effects of sex on coronary microvascular dysfunction and cardiac outcomes. Circulation 2014;129:2518-27.PubMedPubMedCentralCrossRef Murthy VL, Naya M, Taqueti VR, Foster CR, Gaber M, Hainer J, et al. Effects of sex on coronary microvascular dysfunction and cardiac outcomes. Circulation 2014;129:2518-27.PubMedPubMedCentralCrossRef
115.
Zurück zum Zitat Naya M, Murthy VL, Foster CR, Gaber M, Klein J, Hainer J, et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol 2013;61:2098-106.PubMedPubMedCentralCrossRef Naya M, Murthy VL, Foster CR, Gaber M, Klein J, Hainer J, et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol 2013;61:2098-106.PubMedPubMedCentralCrossRef
116.
Zurück zum Zitat Taqueti VR, Everett BM, Murthy VL, Gaber M, Foster CR, Hainer J, et al. Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 2015;131:528-35.PubMedCrossRef Taqueti VR, Everett BM, Murthy VL, Gaber M, Foster CR, Hainer J, et al. Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 2015;131:528-35.PubMedCrossRef
117.
Zurück zum Zitat Taqueti VR, Groarke J, Osborne M, Shah A, Murthy V, Hainer J, et al. Impaired coronary flow reserve is associated with diastolic dysfunction and HFpEF outcomes in patients without overt CAD. JACC 2017;S69:2562 (abstr).CrossRef Taqueti VR, Groarke J, Osborne M, Shah A, Murthy V, Hainer J, et al. Impaired coronary flow reserve is associated with diastolic dysfunction and HFpEF outcomes in patients without overt CAD. JACC 2017;S69:2562 (abstr).CrossRef
118.
Zurück zum Zitat Sheikine Y, Di Carli MF. Integrated PET/CT in the assessment of etiology and viability in ischemic heart failure. Curr Heart Fail Rep 2008;5:136-42.PubMedCrossRef Sheikine Y, Di Carli MF. Integrated PET/CT in the assessment of etiology and viability in ischemic heart failure. Curr Heart Fail Rep 2008;5:136-42.PubMedCrossRef
119.
Zurück zum Zitat Hulten E, Aslam S, Osborne M, Abbasi S, Bittencourt MS, Blankstein R. Cardiac sarcoidosis-state of the art review. Cardiovasc Diagn Ther 2016;6:50-63.PubMedPubMedCentral Hulten E, Aslam S, Osborne M, Abbasi S, Bittencourt MS, Blankstein R. Cardiac sarcoidosis-state of the art review. Cardiovasc Diagn Ther 2016;6:50-63.PubMedPubMedCentral
120.
Zurück zum Zitat Xie JX, Shaw LJ. Measuring diagnostic health care costs in stable coronary artery disease: Should we follow the money? Ann Intern Med 2016;165:147-8.PubMedCrossRef Xie JX, Shaw LJ. Measuring diagnostic health care costs in stable coronary artery disease: Should we follow the money? Ann Intern Med 2016;165:147-8.PubMedCrossRef
121.
Zurück zum Zitat Lee AJ, Michail M, Quaderi SA, Richardson JA, Aggarwal SK, Speechly-Dick ME. Implementation of NICE clinical guideline 95 for assessment of stable chest pain in a rapid access chest pain clinic reduces the mean number of investigations and cost per patient. Open Heart 2015;2:e000151.PubMedPubMedCentralCrossRef Lee AJ, Michail M, Quaderi SA, Richardson JA, Aggarwal SK, Speechly-Dick ME. Implementation of NICE clinical guideline 95 for assessment of stable chest pain in a rapid access chest pain clinic reduces the mean number of investigations and cost per patient. Open Heart 2015;2:e000151.PubMedPubMedCentralCrossRef
122.
Zurück zum Zitat Shaw LJ, Hachamovitch R, Berman DS, Marwick TH, Lauer MS, Heller GV, et al. The economic consequences of available diagnostic and prognostic strategies for the evaluation of stable angina patients: An observational assessment of the value of precatheterization ischemia. Economics of noninvasive diagnosis (END) multicenter study group. J Am Coll Cardiol 1999;33:661-9.PubMedCrossRef Shaw LJ, Hachamovitch R, Berman DS, Marwick TH, Lauer MS, Heller GV, et al. The economic consequences of available diagnostic and prognostic strategies for the evaluation of stable angina patients: An observational assessment of the value of precatheterization ischemia. Economics of noninvasive diagnosis (END) multicenter study group. J Am Coll Cardiol 1999;33:661-9.PubMedCrossRef
123.
Zurück zum Zitat Shaw LJ, Heller GV, Travin MI, Lauer M, Marwick T, Hachamovitch R, et al. Cost analysis of diagnostic testing for coronary artery disease in women with stable chest pain. Economics of noninvasive diagnosis (END) study group. J Nucl Cardiol 1999;6:559-69.PubMedCrossRef Shaw LJ, Heller GV, Travin MI, Lauer M, Marwick T, Hachamovitch R, et al. Cost analysis of diagnostic testing for coronary artery disease in women with stable chest pain. Economics of noninvasive diagnosis (END) study group. J Nucl Cardiol 1999;6:559-69.PubMedCrossRef
124.
Zurück zum Zitat Merhige ME, Breen WJ, Shelton V, Houston T, D’Arcy BJ, Perna AF. Impact of myocardial perfusion imaging with PET and (82)Rb on downstream invasive procedure utilization, costs, and outcomes in coronary disease management. J Nucl Med 2007;48:1069-76.PubMedCrossRef Merhige ME, Breen WJ, Shelton V, Houston T, D’Arcy BJ, Perna AF. Impact of myocardial perfusion imaging with PET and (82)Rb on downstream invasive procedure utilization, costs, and outcomes in coronary disease management. J Nucl Med 2007;48:1069-76.PubMedCrossRef
125.
Zurück zum Zitat Shaw LJ, Marwick TH, Berman DS, Sawada S, Heller GV, Vasey C, et al. Incremental cost-effectiveness of exercise echocardiography vs SPECT imaging for the evaluation of stable chest pain. Eur Heart J 2006;27:2448-58.PubMedCrossRef Shaw LJ, Marwick TH, Berman DS, Sawada S, Heller GV, Vasey C, et al. Incremental cost-effectiveness of exercise echocardiography vs SPECT imaging for the evaluation of stable chest pain. Eur Heart J 2006;27:2448-58.PubMedCrossRef
126.
Zurück zum Zitat Douglas PS, Hoffmann U. Anatomical versus functional testing for coronary artery disease. N Engl J Med 2015;373:91.PubMedCrossRef Douglas PS, Hoffmann U. Anatomical versus functional testing for coronary artery disease. N Engl J Med 2015;373:91.PubMedCrossRef
127.
Zurück zum Zitat Mark DB, Federspiel JJ, Cowper PA, Anstrom KJ, Hoffmann U, Patel MR, et al. Economic outcomes with anatomical versus functional diagnostic testing for coronary artery disease. Ann Intern Med 2016;165:94-102.PubMedPubMedCentralCrossRef Mark DB, Federspiel JJ, Cowper PA, Anstrom KJ, Hoffmann U, Patel MR, et al. Economic outcomes with anatomical versus functional diagnostic testing for coronary artery disease. Ann Intern Med 2016;165:94-102.PubMedPubMedCentralCrossRef
128.
Zurück zum Zitat Jespersen L, Hvelplund A, Abildstrom SZ, Pedersen F, Galatius S, Madsen JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. Eur Heart J 2012;33:734-44.PubMedCrossRef Jespersen L, Hvelplund A, Abildstrom SZ, Pedersen F, Galatius S, Madsen JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. Eur Heart J 2012;33:734-44.PubMedCrossRef
129.
Zurück zum Zitat Schauer DA, Linton OW. NCRP, Report No. 160, ionizing radiation exposure of the Population of the United States, medical exposure—are we doing less with more, and is there a role for health physicists? Health Phys 2009;97:1-5.PubMedCrossRef Schauer DA, Linton OW. NCRP, Report No. 160, ionizing radiation exposure of the Population of the United States, medical exposure—are we doing less with more, and is there a role for health physicists? Health Phys 2009;97:1-5.PubMedCrossRef
130.
Zurück zum Zitat Fazel R, Gerber TC, Balter S, Brenner DJ, Carr JJ, Cerqueira MD, et al. Approaches to enhancing radiation safety in cardiovascular imaging: A scientific statement from the American Heart Association. Circulation 2014;130:1730-48.CrossRefPubMed Fazel R, Gerber TC, Balter S, Brenner DJ, Carr JJ, Cerqueira MD, et al. Approaches to enhancing radiation safety in cardiovascular imaging: A scientific statement from the American Heart Association. Circulation 2014;130:1730-48.CrossRefPubMed
131.
Zurück zum Zitat deKemp RA, Wells RG, Beanlands RS. Women image wisely: The 3 mSv challenge for nuclear cardiology. JACC Cardiovasc Imaging 2016;9:385-7.PubMedCrossRef deKemp RA, Wells RG, Beanlands RS. Women image wisely: The 3 mSv challenge for nuclear cardiology. JACC Cardiovasc Imaging 2016;9:385-7.PubMedCrossRef
132.
Zurück zum Zitat Cerqueira MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol 2010;17:709-18.CrossRefPubMed Cerqueira MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol 2010;17:709-18.CrossRefPubMed
133.
Zurück zum Zitat DePuey EG. Patient-centered imaging: More relevant (and perhaps more elusive) than ever. J Nucl Cardiol 2014;21:661-5.PubMedCrossRef DePuey EG. Patient-centered imaging: More relevant (and perhaps more elusive) than ever. J Nucl Cardiol 2014;21:661-5.PubMedCrossRef
134.
Zurück zum Zitat Fazel R, Shaw LJ. Radiation exposure from radionuclide myocardial perfusion imaging: Concerns and solutions. J Nucl Cardiol 2011;18:562-5.PubMedCrossRef Fazel R, Shaw LJ. Radiation exposure from radionuclide myocardial perfusion imaging: Concerns and solutions. J Nucl Cardiol 2011;18:562-5.PubMedCrossRef
135.
Zurück zum Zitat Fazel R, Dilsizian V, Einstein AJ, Ficaro EP, Henzlova M, Shaw LJ. Strategies for defining an optimal risk-benefit ratio for stress myocardial perfusion SPECT. J Nucl Cardiol 2011;18:385-92.PubMedCrossRef Fazel R, Dilsizian V, Einstein AJ, Ficaro EP, Henzlova M, Shaw LJ. Strategies for defining an optimal risk-benefit ratio for stress myocardial perfusion SPECT. J Nucl Cardiol 2011;18:385-92.PubMedCrossRef
136.
Zurück zum Zitat Berrington de Gonzalez A, Kim KP, Smith-Bindman R, McAreavey D. Myocardial perfusion scans: Projected population cancer risks from current levels of use in the United States. Circulation 2010;122:2403-10.PubMedCrossRef Berrington de Gonzalez A, Kim KP, Smith-Bindman R, McAreavey D. Myocardial perfusion scans: Projected population cancer risks from current levels of use in the United States. Circulation 2010;122:2403-10.PubMedCrossRef
137.
Zurück zum Zitat Doukky R, Frogge N, Appis A, et al. Impact of appropriate use on the estimated radiation risk to men and women undergoing radionuclide myocardial perfusion imaging. J Nucl Med 2016;57:1251-7.PubMedCrossRef Doukky R, Frogge N, Appis A, et al. Impact of appropriate use on the estimated radiation risk to men and women undergoing radionuclide myocardial perfusion imaging. J Nucl Med 2016;57:1251-7.PubMedCrossRef
138.
Zurück zum Zitat Gerber TC, Carr JJ, Arai AE, Dixon RL, Ferrari VA, Gomes AS, et al. Ionizing radiation in cardiac imaging: a science advisory from the American Heart Association Committee on Cardiac Imaging of the Council on Clinical Cardiology and Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention. Circulation 2009;119:1056-65.CrossRefPubMed Gerber TC, Carr JJ, Arai AE, Dixon RL, Ferrari VA, Gomes AS, et al. Ionizing radiation in cardiac imaging: a science advisory from the American Heart Association Committee on Cardiac Imaging of the Council on Clinical Cardiology and Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention. Circulation 2009;119:1056-65.CrossRefPubMed
139.
Zurück zum Zitat Depuey EG, Mahmarian JJ, Miller TD, Einstein AJ, Hansen CL, Holly TA, et al. Patient-centered imaging. J Nucl Cardiol 2012;19:185-215.PubMedCrossRef Depuey EG, Mahmarian JJ, Miller TD, Einstein AJ, Hansen CL, Holly TA, et al. Patient-centered imaging. J Nucl Cardiol 2012;19:185-215.PubMedCrossRef
140.
Zurück zum Zitat Doukky R, Hayes K, Frogge N, Balakrishnan G, Dontaraju VS, Rangel MO, et al. Impact of appropriate use on the prognostic value of single-photon emission computed tomography myocardial perfusion imaging. Circulation 2013;128:1634-43.PubMedCrossRef Doukky R, Hayes K, Frogge N, Balakrishnan G, Dontaraju VS, Rangel MO, et al. Impact of appropriate use on the prognostic value of single-photon emission computed tomography myocardial perfusion imaging. Circulation 2013;128:1634-43.PubMedCrossRef
141.
Zurück zum Zitat Doukky R, Hayes K, Frogge N. Appropriate use criteria for SPECT myocardial perfusion imaging: Are they appropriate for women? J Nucl Cardiol 2015. Doukky R, Hayes K, Frogge N. Appropriate use criteria for SPECT myocardial perfusion imaging: Are they appropriate for women? J Nucl Cardiol 2015.
142.
Zurück zum Zitat Shi L, Dorbala S, Paez D, Shaw LJ, Zukotynski KA, Pascual TN, et al. Gender differences in radiation dose from nuclear cardiology studies across the world: Findings from the INCAPS Registry. JACC Cardiovasc Imaging 2016;9:376-84.PubMedPubMedCentralCrossRef Shi L, Dorbala S, Paez D, Shaw LJ, Zukotynski KA, Pascual TN, et al. Gender differences in radiation dose from nuclear cardiology studies across the world: Findings from the INCAPS Registry. JACC Cardiovasc Imaging 2016;9:376-84.PubMedPubMedCentralCrossRef
143.
Zurück zum Zitat Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39.PubMedCrossRef Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39.PubMedCrossRef
144.
Zurück zum Zitat Jerome SD, Tilkemeier PL, Farrell MB, Shaw LJ. Nationwide laboratory adherence to myocardial perfusion imaging radiation dose reduction practices: A report from the Intersocietal Accreditation Commission Data Repository. JACC Cardiovasc Imaging 2015;8:1170-6.PubMedCrossRef Jerome SD, Tilkemeier PL, Farrell MB, Shaw LJ. Nationwide laboratory adherence to myocardial perfusion imaging radiation dose reduction practices: A report from the Intersocietal Accreditation Commission Data Repository. JACC Cardiovasc Imaging 2015;8:1170-6.PubMedCrossRef
145.
Zurück zum Zitat Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Dondi M, Paez D, et al. Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the United States and worldwide. JAMA Intern Med 2016;176:269-73.PubMedCrossRef Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Dondi M, Paez D, et al. Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the United States and worldwide. JAMA Intern Med 2016;176:269-73.PubMedCrossRef
146.
Zurück zum Zitat Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Rehani MM, Paez D, et al. Comparison of radiation doses and best-practice use for myocardial perfusion imaging in US and non-US Laboratories: Findings from the IAEA (International Atomic Energy Agency) nuclear cardiology protocols study. JAMA Intern Med 2016;176:266-9.PubMedCrossRef Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Rehani MM, Paez D, et al. Comparison of radiation doses and best-practice use for myocardial perfusion imaging in US and non-US Laboratories: Findings from the IAEA (International Atomic Energy Agency) nuclear cardiology protocols study. JAMA Intern Med 2016;176:266-9.PubMedCrossRef
147.
Zurück zum Zitat Einstein AJ, Tilkemeier P, Fazel R, Rakotoarivelo H, Shaw LJ, American Society of Nuclear C. Radiation safety in nuclear cardiology-current knowledge and practice: Results from the 2011 American Society of Nuclear Cardiology member survey. JAMA Intern Med 2013;173:1021-3.PubMedCrossRef Einstein AJ, Tilkemeier P, Fazel R, Rakotoarivelo H, Shaw LJ, American Society of Nuclear C. Radiation safety in nuclear cardiology-current knowledge and practice: Results from the 2011 American Society of Nuclear Cardiology member survey. JAMA Intern Med 2013;173:1021-3.PubMedCrossRef
148.
Zurück zum Zitat Tilkemeier P, Green J, Einstein AJ, Fazel R, Reames P, Shaw LJ. The evolving practice of nuclear cardiology: Results from the 2011 ASNC member survey. J Nucl Cardiol 2012;19:1170-5.PubMedCrossRef Tilkemeier P, Green J, Einstein AJ, Fazel R, Reames P, Shaw LJ. The evolving practice of nuclear cardiology: Results from the 2011 ASNC member survey. J Nucl Cardiol 2012;19:1170-5.PubMedCrossRef
149.
Zurück zum Zitat Rozanski A, Gransar H, Hayes SW, Min J, Friedman JD, Thomson LE, et al. Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009. J Am Coll Cardiol 2013;61:1054-65.CrossRefPubMed Rozanski A, Gransar H, Hayes SW, Min J, Friedman JD, Thomson LE, et al. Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009. J Am Coll Cardiol 2013;61:1054-65.CrossRefPubMed
150.
Zurück zum Zitat Duvall WL, Rai M, Ahlberg AW, O’Sullivan DM, Henzlova MJ. A multi-center assessment of the temporal trends in myocardial perfusion imaging. J Nucl Cardiol 2015;22:539-51.PubMedCrossRef Duvall WL, Rai M, Ahlberg AW, O’Sullivan DM, Henzlova MJ. A multi-center assessment of the temporal trends in myocardial perfusion imaging. J Nucl Cardiol 2015;22:539-51.PubMedCrossRef
151.
Zurück zum Zitat Mahmarian JJ. Implementation of stress-only imaging: What will it take? J Nucl Cardiol 2015. Mahmarian JJ. Implementation of stress-only imaging: What will it take? J Nucl Cardiol 2015.
152.
Zurück zum Zitat Mathur S, Heller GV, Bateman TM, Ruffin R, Yekta A, Katten D, et al. Clinical value of stress-only Tc-99m SPECT imaging: importance of attenuation correction. J Nucl Cardiol 2013;20:27-37.PubMedCrossRef Mathur S, Heller GV, Bateman TM, Ruffin R, Yekta A, Katten D, et al. Clinical value of stress-only Tc-99m SPECT imaging: importance of attenuation correction. J Nucl Cardiol 2013;20:27-37.PubMedCrossRef
153.
Zurück zum Zitat McMahon SR, Kikut J, Pinckney RG, Keating FK. Feasibility of stress only rubidium-82 PET myocardial perfusion imaging. J Nucl Cardiol 2013;20:1069-75.PubMedCrossRef McMahon SR, Kikut J, Pinckney RG, Keating FK. Feasibility of stress only rubidium-82 PET myocardial perfusion imaging. J Nucl Cardiol 2013;20:1069-75.PubMedCrossRef
154.
Zurück zum Zitat Pazhenkottil AP, Kaufmann PA, Gaemperli O. Attenuation correction in stress-only myocardial perfusion imaging. J Nucl Cardiol 2016. Pazhenkottil AP, Kaufmann PA, Gaemperli O. Attenuation correction in stress-only myocardial perfusion imaging. J Nucl Cardiol 2016.
155.
Zurück zum Zitat Henzlova MJ, Croft LB, Duvall WL. Stress-only imaging: Faster, cheaper, less radiation. So what’s the hold up? J Nucl Cardiol 2013;20:17-9.PubMedCrossRef Henzlova MJ, Croft LB, Duvall WL. Stress-only imaging: Faster, cheaper, less radiation. So what’s the hold up? J Nucl Cardiol 2013;20:17-9.PubMedCrossRef
156.
Zurück zum Zitat Duvall WL, Hiensch RJ, Levine EJ, Croft LB, Henzlova MJ. The prognosis of a normal Tl-201 stress-only SPECT MPI study. J Nucl Cardiol 2012;19:914-21.PubMedCrossRef Duvall WL, Hiensch RJ, Levine EJ, Croft LB, Henzlova MJ. The prognosis of a normal Tl-201 stress-only SPECT MPI study. J Nucl Cardiol 2012;19:914-21.PubMedCrossRef
157.
Zurück zum Zitat Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39.PubMedCrossRef Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39.PubMedCrossRef
158.
Zurück zum Zitat Slomka PJ, Dey D, Duvall WL, Henzlova MJ, Berman DS, Germano G. Advances in nuclear cardiac instrumentation with a view towards reduced radiation exposure. Curr Cardiol Rep 2012;14:208-16.PubMedPubMedCentralCrossRef Slomka PJ, Dey D, Duvall WL, Henzlova MJ, Berman DS, Germano G. Advances in nuclear cardiac instrumentation with a view towards reduced radiation exposure. Curr Cardiol Rep 2012;14:208-16.PubMedPubMedCentralCrossRef
159.
Zurück zum Zitat Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol 2009;16:255-76.CrossRefPubMed Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol 2009;16:255-76.CrossRefPubMed
160.
Zurück zum Zitat DePuey EG, Gadiraju R, Clark J, Thompson L, Anstett F, Shwartz SC. Ordered subset expectation maximization and wide beam reconstruction “half-time” gated myocardial perfusion SPECT functional imaging: A comparison to “full-time” filtered backprojection. J Nucl Cardiol 2008;15:547-63.CrossRefPubMed DePuey EG, Gadiraju R, Clark J, Thompson L, Anstett F, Shwartz SC. Ordered subset expectation maximization and wide beam reconstruction “half-time” gated myocardial perfusion SPECT functional imaging: A comparison to “full-time” filtered backprojection. J Nucl Cardiol 2008;15:547-63.CrossRefPubMed
161.
Zurück zum Zitat Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, et al. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 2009;16:714-25.CrossRefPubMed Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, et al. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 2009;16:714-25.CrossRefPubMed
162.
Zurück zum Zitat Einstein AJ, Blankstein R, Andrews H, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: The MILLISIEVERT study. J Nucl Med 2014;55:1430-7.PubMedCrossRef Einstein AJ, Blankstein R, Andrews H, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: The MILLISIEVERT study. J Nucl Med 2014;55:1430-7.PubMedCrossRef
163.
Zurück zum Zitat Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol 2011;18:847-57.PubMedCrossRef Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol 2011;18:847-57.PubMedCrossRef
164.
Zurück zum Zitat Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: Comparison to coronary angiography. J Nucl Cardiol 2012;19:19-27.PubMedCrossRef Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: Comparison to coronary angiography. J Nucl Cardiol 2012;19:19-27.PubMedCrossRef
165.
Zurück zum Zitat Einstein AJ, Blankstein R, Andrews H, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: The MILLISIEVERT study. J Nucl Med 2014;55:1430-7.PubMedCrossRef Einstein AJ, Blankstein R, Andrews H, et al. Comparison of image quality, myocardial perfusion, and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: The MILLISIEVERT study. J Nucl Med 2014;55:1430-7.PubMedCrossRef
166.
Zurück zum Zitat Thompson RC, O’Keefe JH, McGhie AI, Bybee KA, Thompson EC, Bateman TM. Reduction of SPECT MPI radiation dose using contemporary protocols and technology. JACC Cardiovasc Imaging 2017; 2259. Thompson RC, O’Keefe JH, McGhie AI, Bybee KA, Thompson EC, Bateman TM. Reduction of SPECT MPI radiation dose using contemporary protocols and technology. JACC Cardiovasc Imaging 2017; 2259.
168.
Zurück zum Zitat Greenwood JP, Motwani M, Maredia N, Brown JM, Everett CC, Nixon J, et al. Comparison of cardiovascular magnetic resonance and single-photon emission computed tomography in women with suspected coronary artery disease from the clinical evaluation of magnetic resonance imaging in coronary heart disease (CE-MARC) Trial. Circulation 2014;129:1129-38.PubMedCrossRef Greenwood JP, Motwani M, Maredia N, Brown JM, Everett CC, Nixon J, et al. Comparison of cardiovascular magnetic resonance and single-photon emission computed tomography in women with suspected coronary artery disease from the clinical evaluation of magnetic resonance imaging in coronary heart disease (CE-MARC) Trial. Circulation 2014;129:1129-38.PubMedCrossRef
169.
Zurück zum Zitat Pagidipati NJ, Hemal K, Coles A, Mark DB, Dolor RJ, Pellikka PA, et al. Sex differences in functional and CT angiography testing in patients with suspected coronary artery disease. J Am Coll Cardiol 2016;67:2607-16.PubMedPubMedCentralCrossRef Pagidipati NJ, Hemal K, Coles A, Mark DB, Dolor RJ, Pellikka PA, et al. Sex differences in functional and CT angiography testing in patients with suspected coronary artery disease. J Am Coll Cardiol 2016;67:2607-16.PubMedPubMedCentralCrossRef
170.
Zurück zum Zitat Hemal K, Pagidipati NJ, Coles A, Dolor RJ, Mark DB, Pellikka PA, et al. Sex differences in demographics, risk factors, presentation, and noninvasive testing in stable outpatients with suspected coronary artery disease: Insights from the PROMISE trial. JACC Cardiovasc Imaging 2016;9:337-46.PubMedPubMedCentralCrossRef Hemal K, Pagidipati NJ, Coles A, Dolor RJ, Mark DB, Pellikka PA, et al. Sex differences in demographics, risk factors, presentation, and noninvasive testing in stable outpatients with suspected coronary artery disease: Insights from the PROMISE trial. JACC Cardiovasc Imaging 2016;9:337-46.PubMedPubMedCentralCrossRef
171.
Zurück zum Zitat Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): A prospective trial. Lancet 2012;379:453-60.PubMedPubMedCentralCrossRef Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): A prospective trial. Lancet 2012;379:453-60.PubMedPubMedCentralCrossRef
172.
Zurück zum Zitat SCOT Heart investigators. CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): An open-label, parallel-group, multicentre trial. Lancet 2015;385:2383-91.CrossRef SCOT Heart investigators. CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): An open-label, parallel-group, multicentre trial. Lancet 2015;385:2383-91.CrossRef
173.
Zurück zum Zitat Hemal K, Pagidipati NJ, Coles A, Dolor RJ, Mark DB, Pellikka PA, et al. Sex differences in demographics, risk factors, presentation, and noninvasive testing in stable outpatients with suspected coronary artery disease: Insights from the PROMISE trial. JACC Cardiovasc Imaging 2016;9:337-46.PubMedPubMedCentralCrossRef Hemal K, Pagidipati NJ, Coles A, Dolor RJ, Mark DB, Pellikka PA, et al. Sex differences in demographics, risk factors, presentation, and noninvasive testing in stable outpatients with suspected coronary artery disease: Insights from the PROMISE trial. JACC Cardiovasc Imaging 2016;9:337-46.PubMedPubMedCentralCrossRef
174.
Zurück zum Zitat Ripley DP, Brown JM, Everett CC, Bijsterveld P, Walker S, Sculpher M, et al. Rationale and design of the clinical evaluation of magnetic resonance imaging in coronary heart disease 2 trial (CE-MARC 2): A prospective, multicenter, randomized trial of diagnostic strategies in suspected coronary heart disease. Am Heart J 2015;169:17-24 e1. Ripley DP, Brown JM, Everett CC, Bijsterveld P, Walker S, Sculpher M, et al. Rationale and design of the clinical evaluation of magnetic resonance imaging in coronary heart disease 2 trial (CE-MARC 2): A prospective, multicenter, randomized trial of diagnostic strategies in suspected coronary heart disease. Am Heart J 2015;169:17-24 e1.
175.
Zurück zum Zitat Greenwood JP, Ripley DP, Berry C, McCann GP, Plein S, Bucciarelli-Ducci C, et al. Effect of care guided by cardiovascular magnetic resonance, myocardial perfusion scintigraphy, or NICE guidelines on subsequent unnecessary angiography rates: The CE-MARC 2 randomized clinical trial. JAMA 2016;316:1051-60.PubMedCrossRef Greenwood JP, Ripley DP, Berry C, McCann GP, Plein S, Bucciarelli-Ducci C, et al. Effect of care guided by cardiovascular magnetic resonance, myocardial perfusion scintigraphy, or NICE guidelines on subsequent unnecessary angiography rates: The CE-MARC 2 randomized clinical trial. JAMA 2016;316:1051-60.PubMedCrossRef
176.
177.
Zurück zum Zitat Hemingway H, Langenberg C, Damant J, Frost C, Pyorala K, Barrett-Connor E. Prevalence of angina in women versus men: A systematic review and meta-analysis of international variations across 31 countries. Circulation 2008;117:1526-36.PubMedCrossRef Hemingway H, Langenberg C, Damant J, Frost C, Pyorala K, Barrett-Connor E. Prevalence of angina in women versus men: A systematic review and meta-analysis of international variations across 31 countries. Circulation 2008;117:1526-36.PubMedCrossRef
178.
Zurück zum Zitat Johnson BD, Shaw LJ, Pepine CJ, Reis SE, Kelsey SF, Sopko G, et al. Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: Results from the NIH-NHLBI-sponsored women’s ischaemia syndrome evaluation (WISE) study. Eur Heart J 2006;27:1408-15.PubMedCrossRef Johnson BD, Shaw LJ, Pepine CJ, Reis SE, Kelsey SF, Sopko G, et al. Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: Results from the NIH-NHLBI-sponsored women’s ischaemia syndrome evaluation (WISE) study. Eur Heart J 2006;27:1408-15.PubMedCrossRef
179.
Zurück zum Zitat Figueras J, Domingo E, Ferreira I, Lidon RM, Garcia-Dorado D. Persistent angina pectoris, cardiac mortality and myocardial infarction during a 12 year follow-up in 273 variant angina patients without significant fixed coronary stenosis. Am J Cardiol 2012;110:1249-55.PubMedCrossRef Figueras J, Domingo E, Ferreira I, Lidon RM, Garcia-Dorado D. Persistent angina pectoris, cardiac mortality and myocardial infarction during a 12 year follow-up in 273 variant angina patients without significant fixed coronary stenosis. Am J Cardiol 2012;110:1249-55.PubMedCrossRef
180.
Zurück zum Zitat Brorsson B, Bernstein SJ, Brook RH, Werko L. Quality of life of patients with chronic stable angina before and four years after coronary revascularisation compared with a normal population. Heart 2002;87:140-5.PubMedPubMedCentralCrossRef Brorsson B, Bernstein SJ, Brook RH, Werko L. Quality of life of patients with chronic stable angina before and four years after coronary revascularisation compared with a normal population. Heart 2002;87:140-5.PubMedPubMedCentralCrossRef
181.
Zurück zum Zitat Bairey Merz CN, Handberg EM, Shufelt CL, Mehta PK, Minissian MB, Wei J, et al. A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): Impact on angina and myocardial perfusion reserve. Eur Heart J 2016;37:1504-13.PubMedCrossRef Bairey Merz CN, Handberg EM, Shufelt CL, Mehta PK, Minissian MB, Wei J, et al. A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): Impact on angina and myocardial perfusion reserve. Eur Heart J 2016;37:1504-13.PubMedCrossRef
182.
Zurück zum Zitat Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL. Ischemia and no obstructive coronary artery disease (INOCA): Developing evidence-based therapies and research agenda for the next decade. Circulation 2017;135:1075-92.PubMedCrossRef Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL. Ischemia and no obstructive coronary artery disease (INOCA): Developing evidence-based therapies and research agenda for the next decade. Circulation 2017;135:1075-92.PubMedCrossRef
Metadaten
Titel
Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease—state-of-the-evidence and clinical recommendations
verfasst von
Viviany R. Taqueti, MD, MPH
Sharmila Dorbala, MD, MPH
David Wolinsky, MD
Brian Abbott, MD
Gary V. Heller, MD, PhD
Timothy M. Bateman, MD
Jennifer H. Mieres, MD
Lawrence M. Phillips, MD
Nanette K. Wenger, MD
Leslee J. Shaw, PhD
Publikationsdatum
01.08.2017
Verlag
Springer International Publishing
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 4/2017
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-0926-8

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