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Erschienen in: Current Cardiovascular Imaging Reports 2/2015

01.02.2015 | Cardiac Nuclear Imaging (A Cuocolo, Section Editor)

T 1 Mapping Techniques in Assessment of Ventricular Stiffness

verfasst von: Andris H. Ellims, Andrew J. Taylor

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 2/2015

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Abstract

Myocardial fibrosis is a fundamental process in the development of heart failure and can be quantified by cardiac magnetic resonance (CMR) imaging with T 1 mapping techniques. By measuring post-contrast myocardial T 1 time and obtaining invasively determined ventricular pressure-volume data, a mechanistic link between diffuse myocardial fibrosis and increased ventricular stiffness has recently been identified. The capacity to non-invasively evaluate diffuse myocardial fibrosis may enhance our understanding of cardiac diseases and facilitate trials of novel therapies.
Literatur
1.
2.
Zurück zum Zitat Shah PM. Hypertrophic cardiomyopathy and diastolic dysfunction. J Am Coll Cardiol. 2003;42(2):286–7.PubMedCrossRef Shah PM. Hypertrophic cardiomyopathy and diastolic dysfunction. J Am Coll Cardiol. 2003;42(2):286–7.PubMedCrossRef
3.
Zurück zum Zitat Giannuzzi P, Temporelli PL, Bosimini E, Silva P, Imparato A, Corra U, et al. Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction. J Am Coll Cardiol. 1996;28(2):383–90.PubMedCrossRef Giannuzzi P, Temporelli PL, Bosimini E, Silva P, Imparato A, Corra U, et al. Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction. J Am Coll Cardiol. 1996;28(2):383–90.PubMedCrossRef
4.
Zurück zum Zitat Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997;30(6):1527–33.PubMedCrossRef Nagueh SF, Middleton KJ, Kopelen HA, Zoghbi WA, Quinones MA. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol. 1997;30(6):1527–33.PubMedCrossRef
5.
Zurück zum Zitat Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation. 2000;102(15):1788–94.PubMedCrossRef Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation. 2000;102(15):1788–94.PubMedCrossRef
6.
Zurück zum Zitat Mirsky I, Pasipoularides A. Clinical assessment of diastolic function. Prog Cardiovasc Dis. 1990;32(4):291–318.PubMedCrossRef Mirsky I, Pasipoularides A. Clinical assessment of diastolic function. Prog Cardiovasc Dis. 1990;32(4):291–318.PubMedCrossRef
7.
Zurück zum Zitat Weiss JL, Frederiksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest. 1976;58(3):751–60.PubMedCentralPubMedCrossRef Weiss JL, Frederiksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest. 1976;58(3):751–60.PubMedCentralPubMedCrossRef
8.
Zurück zum Zitat Opdahl A, Remme EW, Helle-Valle T, Lyseggen E, Vartdal T, Pettersen E, et al. Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load. Circulation. 2009;119(19):2578–86.PubMedCrossRef Opdahl A, Remme EW, Helle-Valle T, Lyseggen E, Vartdal T, Pettersen E, et al. Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load. Circulation. 2009;119(19):2578–86.PubMedCrossRef
9.
Zurück zum Zitat Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1997;30(2):474–80.PubMedCrossRef Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1997;30(2):474–80.PubMedCrossRef
10.
Zurück zum Zitat Briguori C, Betocchi S, Losi MA, Manganelli F, Piscione F, Pace L, et al. Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy. Am J Cardiol. 1998;81(2):180–7.PubMedCrossRef Briguori C, Betocchi S, Losi MA, Manganelli F, Piscione F, Pace L, et al. Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy. Am J Cardiol. 1998;81(2):180–7.PubMedCrossRef
11.
Zurück zum Zitat Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure–abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004;350(19):1953–9.PubMedCrossRef Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure–abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004;350(19):1953–9.PubMedCrossRef
12.
Zurück zum Zitat Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment. Circulation. 2002;105(12):1503–8.PubMedCrossRef Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment. Circulation. 2002;105(12):1503–8.PubMedCrossRef
13.
Zurück zum Zitat Heling A, Zimmermann R, Kostin S, Maeno Y, Hein S, Devaux B, et al. Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. Circ Res. 2000;86(8):846–53.PubMedCrossRef Heling A, Zimmermann R, Kostin S, Maeno Y, Hein S, Devaux B, et al. Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. Circ Res. 2000;86(8):846–53.PubMedCrossRef
14.
Zurück zum Zitat Conrad CH, Brooks WW, Hayes JA, Sen S, Robinson KG, Bing OH. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 1995;91(1):161–70.PubMedCrossRef Conrad CH, Brooks WW, Hayes JA, Sen S, Robinson KG, Bing OH. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 1995;91(1):161–70.PubMedCrossRef
15.
Zurück zum Zitat Green JJ, Berger JS, Kramer CM, Salerno M. Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. JACC Cardiovasc Imaging. 2012;5(4):370–7.PubMedCrossRef Green JJ, Berger JS, Kramer CM, Salerno M. Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. JACC Cardiovasc Imaging. 2012;5(4):370–7.PubMedCrossRef
16.
Zurück zum Zitat Iles L, Pfluger H, Lefkovits L, Butler MJ, Kistler PM, Kaye DM, et al. Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death. J Am Coll Cardiol. 2011;57(7):821–8.PubMedCrossRef Iles L, Pfluger H, Lefkovits L, Butler MJ, Kistler PM, Kaye DM, et al. Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death. J Am Coll Cardiol. 2011;57(7):821–8.PubMedCrossRef
17.
Zurück zum Zitat Medugorac I, Jacob R. Characterisation of left ventricular collagen in the rat. Cardiovasc Res. 1983;17(1):15–21.PubMedCrossRef Medugorac I, Jacob R. Characterisation of left ventricular collagen in the rat. Cardiovasc Res. 1983;17(1):15–21.PubMedCrossRef
18.
Zurück zum Zitat Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res. 1988;62(4):757–65.PubMedCrossRef Weber KT, Janicki JS, Shroff SG, Pick R, Chen RM, Bashey RI. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ Res. 1988;62(4):757–65.PubMedCrossRef
19.
Zurück zum Zitat Eghbali M, Weber KT. Collagen and the myocardium: fibrillar structure, biosynthesis and degradation in relation to hypertrophy and its regression. Mol Cell Biochem. 1990;96(1):1–14.PubMedCrossRef Eghbali M, Weber KT. Collagen and the myocardium: fibrillar structure, biosynthesis and degradation in relation to hypertrophy and its regression. Mol Cell Biochem. 1990;96(1):1–14.PubMedCrossRef
20.
Zurück zum Zitat Lukashev ME, Werb Z. ECM signalling: orchestrating cell behaviour and misbehaviour. Trends Cell Biol. 1998;8(11):437–41.PubMedCrossRef Lukashev ME, Werb Z. ECM signalling: orchestrating cell behaviour and misbehaviour. Trends Cell Biol. 1998;8(11):437–41.PubMedCrossRef
21.
Zurück zum Zitat Sun Y, Weber KT. Cardiac remodelling by fibrous tissue: role of local factors and circulating hormones. Ann Med. 1998;30 Suppl 1:3–8.PubMed Sun Y, Weber KT. Cardiac remodelling by fibrous tissue: role of local factors and circulating hormones. Ann Med. 1998;30 Suppl 1:3–8.PubMed
23.
Zurück zum Zitat Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83(6):1849–65.PubMedCrossRef Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83(6):1849–65.PubMedCrossRef
24.
25.
Zurück zum Zitat Weidemann F, Herrmann S, Stork S, Niemann M, Frantz S, Lange V, et al. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation. 2009;120(7):577–84.PubMedCrossRef Weidemann F, Herrmann S, Stork S, Niemann M, Frantz S, Lange V, et al. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation. 2009;120(7):577–84.PubMedCrossRef
26.
27.
Zurück zum Zitat Volders PG, Willems IE, Cleutjens JP, Arends JW, Havenith MG, Daemen MJ. Interstitial collagen is increased in the non-infarcted human myocardium after myocardial infarction. J Mol Cell Cardiol. 1993;25(11):1317–23.PubMedCrossRef Volders PG, Willems IE, Cleutjens JP, Arends JW, Havenith MG, Daemen MJ. Interstitial collagen is increased in the non-infarcted human myocardium after myocardial infarction. J Mol Cell Cardiol. 1993;25(11):1317–23.PubMedCrossRef
28.
Zurück zum Zitat Varnava AM, Elliott PM, Sharma S, McKenna WJ, Davies MJ. Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart. 2000;84(5):476–82.PubMedCentralPubMedCrossRef Varnava AM, Elliott PM, Sharma S, McKenna WJ, Davies MJ. Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart. 2000;84(5):476–82.PubMedCentralPubMedCrossRef
29.
Zurück zum Zitat Patel MR, Cawley PJ, Heitner JF, Klem I, Parker MA, Jaroudi WA, et al. Detection of myocardial damage in patients with sarcoidosis. Circulation. 2009;120(20):1969–77.PubMedCentralPubMedCrossRef Patel MR, Cawley PJ, Heitner JF, Klem I, Parker MA, Jaroudi WA, et al. Detection of myocardial damage in patients with sarcoidosis. Circulation. 2009;120(20):1969–77.PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Kishimoto C, Hiraoka Y. Clinical and experimental studies in myocarditis. Curr Opin Cardiol. 1994;9(3):349–56.PubMedCrossRef Kishimoto C, Hiraoka Y. Clinical and experimental studies in myocarditis. Curr Opin Cardiol. 1994;9(3):349–56.PubMedCrossRef
31.
Zurück zum Zitat Shah C, Hari-Dass R, Raynes JG. Serum amyloid A is an innate immune opsonin for Gram-negative bacteria. Blood. 2006;108(5):1751–7.PubMedCrossRef Shah C, Hari-Dass R, Raynes JG. Serum amyloid A is an innate immune opsonin for Gram-negative bacteria. Blood. 2006;108(5):1751–7.PubMedCrossRef
33.
Zurück zum Zitat Maceira AM, Joshi J, Prasad SK, Moon JC, Perugini E, Harding I, et al. Cardiovascular magnetic resonance in cardiac amyloidosis. Circulation. 2005;111(2):186–93.PubMedCrossRef Maceira AM, Joshi J, Prasad SK, Moon JC, Perugini E, Harding I, et al. Cardiovascular magnetic resonance in cardiac amyloidosis. Circulation. 2005;111(2):186–93.PubMedCrossRef
34.
Zurück zum Zitat Ishikawa Y, Ishii T, Masuda S, Asuwa N, Kiguchi H, Hirai S, et al. Myocardial ischemia due to vascular systemic amyloidosis: a quantitative analysis of autopsy findings on stenosis of the intramural coronary arteries. Pathol Int. 1996;46(3):189–94.PubMedCrossRef Ishikawa Y, Ishii T, Masuda S, Asuwa N, Kiguchi H, Hirai S, et al. Myocardial ischemia due to vascular systemic amyloidosis: a quantitative analysis of autopsy findings on stenosis of the intramural coronary arteries. Pathol Int. 1996;46(3):189–94.PubMedCrossRef
35.
Zurück zum Zitat Scholz TD, Fleagle SR, Burns TL, Skorton DJ. Nuclear magnetic resonance relaxometry of the normal heart: relationship between collagen content and relaxation times of the four chambers. Magn Reson Imaging. 1989;7(6):643–8.PubMedCrossRef Scholz TD, Fleagle SR, Burns TL, Skorton DJ. Nuclear magnetic resonance relaxometry of the normal heart: relationship between collagen content and relaxation times of the four chambers. Magn Reson Imaging. 1989;7(6):643–8.PubMedCrossRef
36.
Zurück zum Zitat Grover-McKay M, Scholz TD, Burns TL, Skorton DJ. Myocardial collagen concentration and nuclear magnetic resonance relaxation times in the spontaneously hypertensive rat. Investig Radiol. 1991;26(3):227–32.CrossRef Grover-McKay M, Scholz TD, Burns TL, Skorton DJ. Myocardial collagen concentration and nuclear magnetic resonance relaxation times in the spontaneously hypertensive rat. Investig Radiol. 1991;26(3):227–32.CrossRef
37.
Zurück zum Zitat Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008;52(19):1574–80.PubMedCrossRef Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008;52(19):1574–80.PubMedCrossRef
38.•
Zurück zum Zitat Sibley CT, Noureldin RA, Gai N, Nacif MS, Liu S, Turkbey EB, et al. T1 mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy. Radiology. 2012;265(3):724–32. One of only a handful of papers demonstrating a histological correlation between T1 time and myocardial fibrosis.PubMedCentralPubMedCrossRef Sibley CT, Noureldin RA, Gai N, Nacif MS, Liu S, Turkbey EB, et al. T1 mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy. Radiology. 2012;265(3):724–32. One of only a handful of papers demonstrating a histological correlation between T1 time and myocardial fibrosis.PubMedCentralPubMedCrossRef
39.
Zurück zum Zitat Messroghli DR, Greiser A, Frohlich M, Dietz R, Schulz-Menger J. Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging: JMRI. 2007;26(4):1081–6.PubMedCrossRef Messroghli DR, Greiser A, Frohlich M, Dietz R, Schulz-Menger J. Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart. J Magn Reson Imaging: JMRI. 2007;26(4):1081–6.PubMedCrossRef
40.
Zurück zum Zitat Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2013;15(1):92. Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, et al. Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2013;15(1):92.
41.
Zurück zum Zitat Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2004;52(1):141–6.CrossRef Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2004;52(1):141–6.CrossRef
42.
Zurück zum Zitat Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 2011;57(8):891–903.PubMedCrossRef Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 2011;57(8):891–903.PubMedCrossRef
43.
Zurück zum Zitat Piechnik SK, Ferreira VM, Dall’Armellina E, Cochlin LE, Greiser A, Neubauer S, et al. Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2010;12:69. Piechnik SK, Ferreira VM, Dall’Armellina E, Cochlin LE, Greiser A, Neubauer S, et al. Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2010;12:69.
44.
Zurück zum Zitat Bull S, White SK, Piechnik SK, Flett AS, Ferreira VM, Loudon M, et al. Human non-contrast T1 values and correlation with histology in diffuse fibrosis. Heart. 2013;99(13):932–7.PubMedCentralPubMedCrossRef Bull S, White SK, Piechnik SK, Flett AS, Ferreira VM, Loudon M, et al. Human non-contrast T1 values and correlation with histology in diffuse fibrosis. Heart. 2013;99(13):932–7.PubMedCentralPubMedCrossRef
45.
Zurück zum Zitat Ugander M, Bagi PS, Oki AJ, Chen B, Hsu LY, Aletras AH, et al. Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction. J Am Coll Cardiol Img. 2012;5(6):596–603.CrossRef Ugander M, Bagi PS, Oki AJ, Chen B, Hsu LY, Aletras AH, et al. Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction. J Am Coll Cardiol Img. 2012;5(6):596–603.CrossRef
46.
Zurück zum Zitat Karamitsos TD, Piechnik SK, Banypersad SM, Fontana M, Ntusi NB, Ferreira VM, et al. Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging. 2013;6(4):488–97.PubMedCrossRef Karamitsos TD, Piechnik SK, Banypersad SM, Fontana M, Ntusi NB, Ferreira VM, et al. Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging. 2013;6(4):488–97.PubMedCrossRef
47.
Zurück zum Zitat Pedersen SF, Thrysoe SA, Robich MP, Paaske WP, Ringgaard S, Botker HE, et al. Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2012;14:59. Pedersen SF, Thrysoe SA, Robich MP, Paaske WP, Ringgaard S, Botker HE, et al. Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction. J Cardiovasc Magn Reson Off J Soc Cardiovasc Magn Reson. 2012;14:59.
48.
Zurück zum Zitat Messroghli DR, Walters K, Plein S, Sparrow P, Friedrich MG, Ridgway JP, et al. Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2007;58(1):34–40.CrossRef Messroghli DR, Walters K, Plein S, Sparrow P, Friedrich MG, Ridgway JP, et al. Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2007;58(1):34–40.CrossRef
49.
Zurück zum Zitat Moon JC, Treibel TA, Schelbert EB. T1 mapping for diffuse myocardial fibrosis: a key biomarker in cardiac disease? J Am Coll Cardiol. 2013;62(14):1288–9.PubMedCrossRef Moon JC, Treibel TA, Schelbert EB. T1 mapping for diffuse myocardial fibrosis: a key biomarker in cardiac disease? J Am Coll Cardiol. 2013;62(14):1288–9.PubMedCrossRef
50.
Zurück zum Zitat Gai N, Turkbey EB, Nazarian S, van der Geest RJ, Liu CY, Lima JA, et al. T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2011;65(5):1407–15.CrossRef Gai N, Turkbey EB, Nazarian S, van der Geest RJ, Liu CY, Lima JA, et al. T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison. Magn Reson Med Off J Soc Magn Reson Med / Soc Magn Reson Med. 2011;65(5):1407–15.CrossRef
51.
Zurück zum Zitat Jerosch-Herold M, Sheridan DC, Kushner JD, Nauman D, Burgess D, Dutton D, et al. Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008;295(3):H1234–42.PubMedCentralPubMedCrossRef Jerosch-Herold M, Sheridan DC, Kushner JD, Nauman D, Burgess D, Dutton D, et al. Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008;295(3):H1234–42.PubMedCentralPubMedCrossRef
52.
Zurück zum Zitat Cleutjens JP, Verluyten MJ, Smiths JF, Daemen MJ. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol. 1995;147(2):325–38.PubMedCentralPubMed Cleutjens JP, Verluyten MJ, Smiths JF, Daemen MJ. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol. 1995;147(2):325–38.PubMedCentralPubMed
53.
Zurück zum Zitat Tsuda T, Gao E, Evangelisti L, Markova D, Ma X, Chu ML. Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Cardiovasc Res. 2003;59(4):926–33.PubMedCrossRef Tsuda T, Gao E, Evangelisti L, Markova D, Ma X, Chu ML. Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Cardiovasc Res. 2003;59(4):926–33.PubMedCrossRef
54.
Zurück zum Zitat Chan W, Duffy SJ, White DA, Gao XM, Du XJ, Ellims AH, et al. Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. J Am Coll Cardiol Img. 2012;5(9):884–93.CrossRef Chan W, Duffy SJ, White DA, Gao XM, Du XJ, Ellims AH, et al. Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. J Am Coll Cardiol Img. 2012;5(9):884–93.CrossRef
55.
Zurück zum Zitat Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation. 1994;89(1):151–63.PubMedCrossRef Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation. 1994;89(1):151–63.PubMedCrossRef
56.•
Zurück zum Zitat Puntmann VO, Arroyo Ucar E, Hinojar Baydes R, Ngah NB, Kuo YS, Dabir D, et al. Aortic stiffness and interstitial myocardial fibrosis by native t1 are independently associated with left ventricular remodeling in patients with dilated cardiomyopathy. Hypertension. 2014;64(4):762–8. An important paper linking non-contrast T1 time and LV remodelling in dilated cardiomyopathy.PubMedCrossRef Puntmann VO, Arroyo Ucar E, Hinojar Baydes R, Ngah NB, Kuo YS, Dabir D, et al. Aortic stiffness and interstitial myocardial fibrosis by native t1 are independently associated with left ventricular remodeling in patients with dilated cardiomyopathy. Hypertension. 2014;64(4):762–8. An important paper linking non-contrast T1 time and LV remodelling in dilated cardiomyopathy.PubMedCrossRef
57.•
Zurück zum Zitat Ellims AH, Iles LM, Ling LH, Hare JL, Kaye DM, Taylor AJ. Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction. J Cardiovasc Magn Reson. 2012;14:76. The first paper to investigate post-contrast T1 time in a typical cohort of patients with HCM - a link between T1 time and ventricular diastolic dysfunction is also described for the first time in these patients.PubMedCentralPubMedCrossRef Ellims AH, Iles LM, Ling LH, Hare JL, Kaye DM, Taylor AJ. Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction. J Cardiovasc Magn Reson. 2012;14:76. The first paper to investigate post-contrast T1 time in a typical cohort of patients with HCM - a link between T1 time and ventricular diastolic dysfunction is also described for the first time in these patients.PubMedCentralPubMedCrossRef
58.
Zurück zum Zitat Ellims AH, Iles LM, Ling LH, Chong B, Macciocca I, Slavin GS, et al. A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype. Eur Heart J Cardiovasc Imaging. 2014. Ellims AH, Iles LM, Ling LH, Chong B, Macciocca I, Slavin GS, et al. A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype. Eur Heart J Cardiovasc Imaging. 2014.
59.
Zurück zum Zitat Dusenbery SM, Jerosch-Herold M, Rickers C, Colan SD, Geva T, Newburger JW, et al. Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis. J Am Coll Cardiol. 2014;63(17):1778–85.PubMedCrossRef Dusenbery SM, Jerosch-Herold M, Rickers C, Colan SD, Geva T, Newburger JW, et al. Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis. J Am Coll Cardiol. 2014;63(17):1778–85.PubMedCrossRef
60.
Zurück zum Zitat Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, et al. Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T(1) mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Circ Cardiovasc Imaging. 2012;5(1):51–9.PubMedCrossRef Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, et al. Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T(1) mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Circ Cardiovasc Imaging. 2012;5(1):51–9.PubMedCrossRef
61.
Zurück zum Zitat Jellis C, Wright J, Kennedy D, Sacre J, Jenkins C, Haluska B, et al. Association of imaging markers of myocardial fibrosis with metabolic and functional disturbances in early diabetic cardiomyopathy. Circ Cardiovasc Imaging. 2011;4(6):693–702.PubMedCrossRef Jellis C, Wright J, Kennedy D, Sacre J, Jenkins C, Haluska B, et al. Association of imaging markers of myocardial fibrosis with metabolic and functional disturbances in early diabetic cardiomyopathy. Circ Cardiovasc Imaging. 2011;4(6):693–702.PubMedCrossRef
62.
Zurück zum Zitat Puntmann VO, D’Cruz D, Smith Z, Pastor A, Choong P, Voigt T, et al. Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosus. Circ Cardiovasc Imaging. 2013;6(2):295–301.PubMedCrossRef Puntmann VO, D’Cruz D, Smith Z, Pastor A, Choong P, Voigt T, et al. Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosus. Circ Cardiovasc Imaging. 2013;6(2):295–301.PubMedCrossRef
63.
Zurück zum Zitat Thuny F, Lovric D, Schnell F, Bergerot C, Ernande L, Cottin V, et al. Quantification of myocardial extracellular volume fraction with cardiac MR imaging for early detection of left ventricle involvement in systemic sclerosis. Radiology. 2014;271(2):373–80.PubMedCrossRef Thuny F, Lovric D, Schnell F, Bergerot C, Ernande L, Cottin V, et al. Quantification of myocardial extracellular volume fraction with cardiac MR imaging for early detection of left ventricle involvement in systemic sclerosis. Radiology. 2014;271(2):373–80.PubMedCrossRef
64.•
Zurück zum Zitat Ellims AH, Shaw JA, Stub D, Iles LM, Hare JL, Slavin GS, et al. Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness. J Am Coll Cardiol. 2014;63(11):1112–8. The first description of a link between diffuse myocardial fibrosis by post-contrast T1 time and invasively-determined markers of LV diastolic dysfunction.PubMedCrossRef Ellims AH, Shaw JA, Stub D, Iles LM, Hare JL, Slavin GS, et al. Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness. J Am Coll Cardiol. 2014;63(11):1112–8. The first description of a link between diffuse myocardial fibrosis by post-contrast T1 time and invasively-determined markers of LV diastolic dysfunction.PubMedCrossRef
65.
Zurück zum Zitat Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Cardiol. 1993;71(3):12A–6.PubMedCrossRef Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Cardiol. 1993;71(3):12A–6.PubMedCrossRef
66.
Zurück zum Zitat Brilla CG. Renin-angiotensin-aldosterone system and myocardial fibrosis. Cardiovasc Res. 2000;47(1):1–3.PubMedCrossRef Brilla CG. Renin-angiotensin-aldosterone system and myocardial fibrosis. Cardiovasc Res. 2000;47(1):1–3.PubMedCrossRef
Metadaten
Titel
T 1 Mapping Techniques in Assessment of Ventricular Stiffness
verfasst von
Andris H. Ellims
Andrew J. Taylor
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 2/2015
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-014-9318-5

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