Introduction
Methods
1. Exercise after chemotherapy | 2. Exercise during chemotherapy | 3. Exercise after SCT | 4. Exercise during childhood cancer | |
---|---|---|---|---|
Intervention duration | 12 weeks | Depending on duration of chemotherapy | 18 weeks | 12 weeks |
Intervention arm 1 | High-intensity resistance and endurance exercise | High-intensity resistance and endurance exercise | High-intensity resistance and endurance exercise | High-intensity resistance and endurance exercise |
Intervention arm 2 | Low-to-moderate intensity resistance and endurance exercise | Low-to-moderate intensity physical activity programme | – | – |
Control arm | Waiting lista
| Usual care | Usual careb
| Usual care |
Study Population
Project | # of patients | Inclusion criteria | Specific exclusion criteriaa
| Participating hospitals |
---|---|---|---|---|
1. Exercise after chemotherapy | 400 | Histological confirmed breast, colon, ovarian cancer or lymphomas with no indication of recurrent or progressive disease | Maxima Medical Center Veldhoven/Eindhoven, Catharina Hospital Eindhoven, Elckerlieck Hospital Helmond, Sint Anna Hospital, Geldrop, VU University Medical Center Amsterdam | |
Aged between 18 and 70 years | ||||
Completion of (adjuvant) chemotherapy with curative intention and completion of surgical treatment or radiotherapy | ||||
2. Exercise during chemotherapy | 360 | Histological confirmed primary breast of primary colon cancer who are scheduled to undergo adjuvant chemotherapy | Amstelland Hospital, Antoni van Leeuwenhoek Hospital, Bovenij Hospital, Flevohospital, Medical Center Alkmaar, Onze Lieve Vrouwe Gasthuis, Rode Kruis Hospital Beverwijk, Sint Lucas Andreas Hospital, Spaarne Hospital Hoofddorp, VU University Medical Center Amsterdam, Waterland Hospital, Zaans Medical Center | |
3. Exercise after SCT | 120 | Haematological malignancies undergoing high dose chemotherapy and autologous SCT | Multiple myeloma undergoing a tandem autologous–allogeneic SCT | Academic Medical Centre Amsterdam, Antoni van Leeuwenhoek Hospital Amsterdam, University Medical Center Utrecht, Antonius Hospital Nieuwegein, Haga Hospital The Hague |
Multiple myeloma in first line; Hodgkin’s lymphoma or non-Hodgkin’s lymphoma in first relapse | Extensive osteolytic lesions with risk of fracture | |||
Aged between 18 and 65 years | Severe infections | |||
Sufficiently recovered from the SCT and having peripheral blood recovery | ||||
4. Exercise during childhood cancer | 100 | Aged 8–18 years at the time of intervention | Bone marrow transplantation | Centre for Paediatric Oncology and Haematology of VU University Medical Center, Wilhelmina Children’s Hospital University Medical Centre Utrecht, Emma Children’s Hospital Academic Medical Center Amsterdam |
Diagnosed with any type of childhood malignancy | Growth hormone treatment | |||
Treated with chemo- and or radiotherapy | ||||
No longer than 12 months off treatment |
Exercise Interventions
Assessments and Outcome Measures
International Classification of Functioning, Disability and Health | |||||
---|---|---|---|---|---|
Second level | Third level | Adults | Children | ||
Body functions | |||||
Chapter 1 | Mental functions | ||||
b122 | Global psychosocial functions | CBCL, YRS | |||
b126 | Temperament and personality functions | CBCL, YRS, CBSA/CBSK (behavioural conduct) | |||
b130 | Energy drive and functions | MFI, FQL | PedsQL Multidimensional Fatigue Scale Acute version | ||
b134 | Sleep functions | PSQI | |||
b152 | Emotional functions | HADS | CDI | ||
b280 | Sensations of pain | EORTC QLQ-C30 symptom scale | |||
Chapter 4 | Functions of the cardiovascular, haematological, immunological and respiratory systems | ||||
b410–b429 | Cardiovascular system functions | Heart rate | Heart rate | ||
b440–b449 | Respiratory system functions | Respiratory rate | Respiratory rate | ||
b455 | Exercise tolerance functions | ||||
b4551 | Aerobic capacity | PeakVO2
| PeakVO2
| ||
b4552 | Fatigability | MFI | |||
Chapter 5 | Functions related to the digestive, metabolic and respiratory systems | ||||
b530 | Weight maintenance | BMI, skinfolds, hip and waist circumference, DEXA scan | BMI, DEXA scan | ||
Chapter 7 | Neuromusculoskeletal and movement-related functions | ||||
b730 | Muscle power function | ||||
b7304 | Power of muscles of all limbs | Upper extremity: handgrip strength | Handheld dynamometer for upper and lower extremity | ||
Lower extremity: 30 s chair stand test | |||||
Activities and participation | |||||
Chapter 4 | Mobility | ||||
d410 | Changing basic body position | ||||
d4103 | Sitting | 30-s chair stand test | |||
d4104 | Standing | 30-s chair stand test | |||
d450 | Walking | PASE and accelerometer | Accelerometer | ||
d460 | Moving around in different locations | IPA (mobility and leisure) | |||
d4600 | Moving around within the home | IPA (mobility and leisure) | |||
d4601 | Moving around within buildings other than home | IPA (mobility and leisure) | |||
d4602 | Moving around outside the home and other buildings | IPA (mobility and leisure) | |||
d470 | Using transportation | d4700 | Using human-powered vehicles | PASE | |
Chapter 5 | Self-care | ||||
d510 | Washing oneself | IPA (autonomy in self-care) | |||
d530 | Toileting | IPA (autonomy in self-care) | |||
d540 | Dressing | IPA (autonomy in self-care) | |||
d550 | Eating | IPA (autonomy in self-care) | |||
d560 | Drinking | IPA (autonomy in self-care) | |||
d570 | Looking after one’s health | IPA (autonomy in self-care) | |||
Chapter 6 | Domestic life | ||||
d620 | Acquisition of goods and services | ||||
d6200 | Shopping | IPA (family role) | |||
d640 | Doing housework | PASE, IPA (family role) | |||
d6402 | Cleaning living area | IPA (family role) | |||
d650 | Caring for household objects | IPA (family role) | |||
Chapter 7 | Interpersonal interactions and relationships | ||||
d750 | Informal social relationships | IPA (social relations) | CBSA/CBSK (close friendships) | ||
d7502 | Informal relationships with co-inhabitants | IPA (social relations) | |||
d760 | Family relationships | IPA (social relations) | |||
d770 | |||||
d7702 | Sexual relationships | IPA (social relations) | |||
Chapter 8 | Major life areas | ||||
d810–d839 | Education | Level of education | Level of education, return to school | ||
CBSA/CBSK (scholastic competence) | |||||
d815 | Preschool education | Level of education | Level of education, return to school | ||
d820 | School education | Level of education | Level of education, return to school | ||
d825 | Vocational training | Level of education | Level of education, return to school | ||
d830 | Higher education | Level of education | Level of education, return to school | ||
d840–d959 | Work and Employment | Type of employment, return to work | |||
d850 | Remunerative employment | Type of employment, return to work | |||
d850 | Self-employment | Type of employment, return to work | |||
d8501 | Part-time employment | ||||
d8502 | Full-time employment | Type of employment, return to work | |||
d855 | Non-remunerative employment | Type of employment, return to work | |||
d870 | Economic self-sufficiency | IPA (family role) | IPA (family role) | ||
d880 | Engagement in play | Accelerometer | |||
Chapter 9 | Community, social and civic life | ||||
d920 | Recreation and leisure | IPA (mobility and leisure) | IPA (mobility and leisure) | ||
d9200 | Play | Accelerometer | |||
d9201 | Sports | PASE and accelerometer | Accelerometer |