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Anatomical Science International

Erschienen in:

24.02.2016 | Review Article

Cell biology of mesangial cells: the third cell that maintains the glomerular capillary

verfasst von: Hidetake Kurihara, Tatsuo Sakai

Erschienen in: Anatomical Science International | Ausgabe 2/2017

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Abstract

The renal glomerulus consists of glomerular endothelial cells, podocytes, and mesangial cells, which cooperate with each other for glomerular filtration. We have produced monoclonal antibodies against glomerular cells in order to identify different types of glomerular cells. Among these antibodies, the E30 clone specifically recognizes the Thy1.1 molecule expressed on mesangial cells. An injection of this antibody into rats resulted in mesangial cell-specific injury within 15 min, and induced mesangial proliferative glomerulonephritis in a reproducible manner. We examined the role of mesangial cells in glomerular function using several experimental tools, including an E30-induced nephritis model, mesangial cell culture, and the deletion of specific genes. Herein, we describe the characterization of E30-induced nephritis, formation of the glomerular capillary network, mesangial matrix turnover, and intercellular signaling between glomerular cells. New molecules that are involved in a wide variety of mesangial cell functions are also introduced.

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Titel: Cell biology of mesangial cells: the third cell that maintains the glomerular capillary
verfasst von: Hidetake Kurihara
Tatsuo Sakai
Publikationsdatum: 24.02.2016
Verlag: Springer Japan
Erschienen in: Anatomical Science International / Ausgabe 2/2017
Print ISSN: 1447-6959
Elektronische ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-016-0334-1

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Cell biology of mesangial cells: the third cell that maintains the glomerular capillary

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