Skip to main content

Advertisement

SpringerLink
Log in

The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial

  • Published:
Probiotics and Antimicrobial Proteins Aims and scope Submit manuscript

Abstract

Diarrhea is considered as an important cause of morbidity and mortality, even though one of the main reasons of death following diarrhea is initiated by dysentery. In recent years, the consumption of probiotics has been proposed for the treatment of infectious diarrhea. Despite most of the studies on probiotics have focused on acute watery diarrhea, few studies in the field of dysentery have found beneficial effects of probiotics. This study is a randomized double-blind clinical trial. The patients were randomly placed into control and case groups. In the intervention group, the patients received probiotics in the form of Kidilact® sachet, which contained high amounts of 7-strain friendly bacteria strains of Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium infantis, Bifidobacterium breve, and Streptococcus thermophiles. On the other hand, the patients in the control group received placebo sachets on a daily basis for 5 days. It is notable that the treatment protocol of acute dysentery was done on both groups. The results of this study showed significant differences in the duration of blood in diarrhea between probiotic consumers (2.62 days) and the control group (3.16 days) (P value = 0.05). Additionally, significant differences in the average length of hospitalization in probiotic consumers (3.16 days) and control (3.66 days), (P value = 0.02) could be claimed that the consumption of probiotics is effective in reducing the duration of dysentery and diarrhea. The results of this study suggest that the use of probiotics can be effective in reducing the duration of blood in diarrhea. This study was also recorded in the Iran center of clinical trials registration database (IRCT2014060617985N1).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Liu L et al (2015) Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 385(9966):430–440

    Article  Google Scholar 

  2. Organization, W.H (2005) The treatment of diarrhoea: a manual for physicians and other senior health workers. WHO, Geneva 2013, WHO/CDD/SER/80.2

    Google Scholar 

  3. Grenov B, et al. (2017) Validation of a simple stool diary used by caregivers to document diarrhea among young children in a low-income country. J Pediatr Gastroenterol Nutr. doi:10.1097/MPG.0000000000001462

  4. Grandy G et al (2010) Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children. BMC Infect Dis 10(1):253

    Article  Google Scholar 

  5. Koletzko S, Osterrieder S (2009) Acute infectious diarrhea in children. Dtsch Arztebl Int 106(33):539–547

    Google Scholar 

  6. Canani RB et al (2007) Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 335(7615):335–340

  7. Cucchiara S et al (2002) New therapeutic approach in the management of intestinal disease: probiotics in intestinal disease in paediatric age. Dig Liver Dis 34:S44–S47

    Article  Google Scholar 

  8. Lotfi A et al (2016) Comparing the effects of two feeding methods on metabolic bone disease in newborns with very low birth weights. Glob J Health Sci 8(1):249–254

  9. Boirivant M, Strober W (2007) The mechanism of action of probiotics. Curr Opin Gastroenterol 23(6):679–692

    Article  Google Scholar 

  10. Petrof EO (2009) Probiotics and gastrointestinal disease: clinical evidence and basic science. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents) 8(3): p. 260–269

  11. Sharif MR et al (2016) The effect of a yeast probiotic on acute diarrhea in children. Probiotics and Antimicrobial Proteins 8(4):211–214

    Article  Google Scholar 

  12. Allen SJ et al (2011) Probiotics for treating acute infectious diarrhoea. Sao Paulo Medical Journal 129(3):185–185

    Article  Google Scholar 

  13. Billoo A et al (2006) Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea. World J Gastroenterol 12(28):4557

    Article  CAS  Google Scholar 

  14. O’Ryan G,M et al (2014) Management of acute infectious diarrhea for children living in resource-limited settings. Expert Rev Anti-Infect Ther 12(5):621–632

    Article  Google Scholar 

  15. Johnston BC et al (2012) Probiotics for the prevention of Clostridium difficile–associated diarrhea: a systematic review and meta-analysis. Ann Intern Med 157(12):878–888

    Article  Google Scholar 

  16. Applegate JA et al (2013) Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children. BMC Public Health 13(3):S16

    Google Scholar 

  17. Guandalini S (2011) Probiotics for prevention and treatment of diarrhea. J Clin Gastroenterol 45:S149–S153

    Article  Google Scholar 

  18. Moorthy G, Murali MR, Devaraj SN (2009) Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats. Nutrition 25(3):350–358

    Article  CAS  Google Scholar 

  19. Htwe K et al (2008) Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children: a randomized controlled study. AmJTrop Med Hyg 78(2):214–216

    Google Scholar 

  20. Guarner F, Malagelada J-R (2003) Gut flora in health and disease. Lancet 361(9356):512–519

    Article  Google Scholar 

  21. Gorbach SL (2000) Probiotics and gastrointestinal health. Am J Gastroenterol 95(1):S2–S4

    Article  CAS  Google Scholar 

  22. Hempel S et al (2012) Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA 307(18):1959–1969

    Article  CAS  Google Scholar 

  23. Simpson H, Campbell B (2015) Review article: dietary fibre–microbiota interactions. Aliment Pharmacol Ther 42(2):158–179

    Article  CAS  Google Scholar 

  24. Marrazzo, J. M., & Apicella, M. A. (2014). Neisseria gonorrhoeae (Gonorrhea). In Mandell, Douglas, andBennett’s Principles and Practice of Infectious Diseases. (Vol. 2). Elsevier Inc. pp. 2446-2462.e3. doi:10.1016/B978-1-4557-4801-3.00214-9

  25. Basu S et al (2007) Efficacy of Lactobacillus rhamnosus GG in acute watery diarrhoea of Indian children: a randomised controlled trial. J Paediatr Child Health 43(12):837–842

    Article  Google Scholar 

  26. Francavilla R et al (2012) Randomised clinical trial: Lactobacillus reuteri DSM 17938 vs. placebo in children with acute diarrhoea—a double-blind study. Aliment Pharmacol Ther 36(4):363–369

    Article  CAS  Google Scholar 

  27. Jalali HK et al (2016) Antagonistic activity of Nocardia brasiliensis PTCC 1422 against isolated Enterobacteriaceae from urinary tract infections. Probiotics and antimicrobial proteins 8(1):41–45

    Article  CAS  Google Scholar 

  28. Ferdosian M et al (2015) Identification of immunotopes against Mycobacterium leprae as immune targets using PhDTm-12mer phage display peptide library. Trop J Pharm Res 14(7):1153–1159

    Article  CAS  Google Scholar 

  29. Kashani HH, Moniri R (2015) Expression of recombinant pET22b-LysK-cysteine/histidine-dependent amidohydrolase/peptidase bacteriophage therapeutic protein in Escherichia coli BL21 (DE3). Osong public health and research perspectives 6(4):256–260

    Article  Google Scholar 

  30. Kashani HH, et al. (2012) Synergism effect of nisin peptide in reducing chemical preservatives in food industry. Life Science Journal 9(1):496–501

  31. Dehghani R et al (2016a) The identification of bacterial flora in oral cavity of snakes. Comp Clin Pathol 25(2):279–283

    Article  CAS  Google Scholar 

  32. Dehghani R et al (2016b) Fungal flora in the mouth of venomous and non-venomous snakes. Comp Clin Pathol 25(6):1207–1211

    Article  CAS  Google Scholar 

  33. Kashani HH et al (2013) Expression of galectin-3 as a testis inflammatory marker in vasectomised mice. Cell J 15(1):11–18

  34. Nikzad H et al (2013) Expression of galectin-8 on human endometrium: molecular and cellular aspects. Iran J Reprod Med 11(1):65–70

  35. Korviakova E (1999) Use of loading doses of bifidumbacterin forte for treatment of patients with acute enteric infections. Zhurnal mikrobiologii, epidemiologii, i immunobiologii (6): p. 58–61

  36. Utemuradova G (2008) Etiology of acute enteric n in children with arid zone and effect of probiotics. Zhurnal mikrobiologii, epidemiologii, i immunobiologii (3): p. 98–100

  37. Vandenplas Y et al (2007) Probiotics in infectious diarrhoea in children: are they indicated? Eur J Pediatr 166(12):1211–1218

    Article  CAS  Google Scholar 

  38. Erdoğan Ö, et al. (2012) The comparition of the efficacy of two different probiotics in rotavirus gastroenteritis in children. J Trop Med 2012;787240. doi:10.1155/2012/787240

  39. Guarino A et al (2014) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 59(1):132–152

    Article  Google Scholar 

  40. Mirnejad R et al (2013) The antimicrobial effect of lactobacillus casei culture supernatant against multiple drug resistant clinical isolates of Shigella sonnei and Shigella flexneri in vitro. Iranian Red Crescent medical journal 15(2):122–126

    Article  Google Scholar 

Download references

Acknowledgements

The researcher wishes to express his appreciation to the full cooperation of the patients who participated in this study and the Clinical Research Center of Shahid Beheshti Hospital. The financial support for this research was provided by a grant no. 93137 from the Research Deputy of Kashan University of Medical Sciences.

Author information

Authors and Affiliations

  1. Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

    Alireza Sharif, Elahe Nasri, Zahra Soleimani & Mohammad Reza Sharif

  2. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran

    Hamed Haddad Kashani

Authors
  1. Alireza Sharif
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hamed Haddad Kashani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elahe Nasri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zahra Soleimani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mohammad Reza Sharif
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohammad Reza Sharif.

Ethics declarations

Ethical Responsibilities of Authors

This paper is our original unpublished work and it has not been submitted to any other journal for reviews.

Conflict of Interest

The authors declare that they have no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharif, A., Kashani, H.H., Nasri, E. et al. The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial. Probiotics & Antimicro. Prot. 9, 380–385 (2017). https://doi.org/10.1007/s12602-017-9271-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12602-017-9271-0

Keywords

Search

Navigation