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01.11.2010

Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures

verfasst von: Pedro Bekinschtein, Cynthia Katche, Leandro Slipczuk, Carolina Gonzalez, Guido Dorman, Martín Cammarota, Iván Izquierdo, Jorge H. Medina

Erschienen in: Neurotoxicity Research | Ausgabe 3-4/2010

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Abstract

Although much is known about long-term memory (LTM) consolidation, what puts the “long” in LTM is the exclusive feature of persisting over time. However, until recently the molecular mechanisms underneath memory persistence had never been properly studied. In rats, the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12 h after inhibitory avoidance (IA) training without affecting memory formation. Here, we also show learning-induced changes in hippocampal c-Fos, Homer 1a, Akt, CamKIIα, and ERK2 levels around 18–24 h after IA training. Thus, memory persistence is associated with a late phase of plasticity-related protein synthesis in the hippocampus.

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Titel: Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures
verfasst von: Pedro Bekinschtein
Cynthia Katche
Leandro Slipczuk
Carolina Gonzalez
Guido Dorman
Martín Cammarota
Iván Izquierdo
Jorge H. Medina
Publikationsdatum: 01.11.2010
Verlag: Springer-Verlag
Erschienen in: Neurotoxicity Research / Ausgabe 3-4/2010
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-010-9155-5

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