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01.11.2013 | Original Article

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

verfasst von: S. Ricci, R. Businaro, F. Ippoliti, V. R. Lo Vasco, F. Massoni, E. Onofri, G. M. Troili, V. Pontecorvi, M. Morelli, M. Rapp Ricciardi, T. Archer

Erschienen in: Neurotoxicity Research | Ausgabe 4/2013

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Abstract

The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-α and BDNF were observed, regardless of age and gender. Comparisons were made with age- and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.

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Titel: Altered Cytokine and BDNF Levels in Autism Spectrum Disorder
verfasst von: S. Ricci
R. Businaro
F. Ippoliti
V. R. Lo Vasco
F. Massoni
E. Onofri
G. M. Troili
V. Pontecorvi
M. Morelli
M. Rapp Ricciardi
T. Archer
Publikationsdatum: 01.11.2013
Verlag: Springer US
Erschienen in: Neurotoxicity Research / Ausgabe 4/2013
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-013-9393-4

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