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Translational Stroke Research
Erschienen in: Translational Stroke Research 3/2013

01.06.2013 | Original Article

In Vivo Animal Stroke Models

A Rationale for Rodent and Non-Human Primate Models

verfasst von: Naoki Tajiri, Travis Dailey, Christopher Metcalf, Yusef I. Mosley, Tsz Lau, Meaghan Staples, Harry van Loveren, Seung U. Kim, Tetsumori Yamashima, Takao Yasuhara, Isao Date, Yuji Kaneko, Cesario V. Borlongan

Erschienen in: Translational Stroke Research | Ausgabe 3/2013

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Abstract

On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188–197, 2012). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke.
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Metadaten
Titel
In Vivo Animal Stroke Models
A Rationale for Rodent and Non-Human Primate Models
verfasst von
Naoki Tajiri
Travis Dailey
Christopher Metcalf
Yusef I. Mosley
Tsz Lau
Meaghan Staples
Harry van Loveren
Seung U. Kim
Tetsumori Yamashima
Takao Yasuhara
Isao Date
Yuji Kaneko
Cesario V. Borlongan
Publikationsdatum
01.06.2013
Verlag
Springer-Verlag
Erschienen in
Translational Stroke Research / Ausgabe 3/2013
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-012-0241-2

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