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In vitro antioxidant properties of mangosteen peel extract

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Abstract

The growing interest in the replacement of synthetic food antioxidants by natural ones has fostered research on the screening of plant-derived raw materials for identifying new antioxidants. The special attention of research today is focused on inexpensive or residual sources from agricultural industries. Fruit peels as sources of powerful natural antioxidants are often the waste parts of various fruits from consumption and food industry. Among the fruit peels, mangosteen peel is an important source of natural phenolic antioxidants. The mangosteen peel contains various bioactive substances, i.e., phenolic acids and flavonoids, which possess biological and medicinal properties, especially antioxidant properties. The aim of this review, after presenting analytical techniques for determining in vitro antioxidant activity of mangosteen peel extract, is to summarize available data on the factors affecting antioxidant activity of mangosteen peel extract. In addition, the potential antioxidant activity of mangosteen peel extract, the bioactive compounds identified from mangosteen peel extract and their antioxidant activity are presented. Potential applications of the mangosteen peel extract in food, pharmaceutical and cosmetic products are also discussed.

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References

  • Ajila CM, Naidu KA, Bhat SG, Rao UJSP (2007) Bioactive compounds and antioxidant potential of mango peel extract. Food Chem 105:982–988

    Article  CAS  Google Scholar 

  • Amano F, Noda T (1995) Improved detection of nitric oxide radical (NO•) production in an activated macrophage culture with a radical scavenger, carboxy PTIO, and Griess reagent. Fed Eur Biochem Soc 368:425–428

    Article  CAS  Google Scholar 

  • Ampasavate C, Okonogi S, Anuchapreeda S (2010) Cytotoxicity of extracts from fruit plants against leukemic cell lines. Afr J Pharm Pharmacol 4:013–021

    Google Scholar 

  • Arnao MB (2000) Some methodological problems in the determination of antioxidant activity using chromogen radicals: a practical case. Trends Food Sci Technol 11:419–421

    Article  CAS  Google Scholar 

  • Asai F, Tosa H, Tanaka T, Iinuma M (1995) A xanthone from pericarps of Garcinia Mangostana. Phytochem 39:943–944

    Article  CAS  Google Scholar 

  • Bin Osman M, Milan AR (2006) Mangosteen-Garcinia mangostana. Southampton Center for Underutilized Crops, University of Southampton, Southampton

    Google Scholar 

  • Bondet V, Brand-Williams W, Berset C (1997) Kinetics and mechanism of antioxidant activity using the DPPH• free radical method. Lebens Wissen Technol 30:609–615

    Article  CAS  Google Scholar 

  • Bunsiri A, Ketsa S, Paull RE (2003) Phenolic metabolism and lignin synthesis in damaged pericarp of mangosteen fruit after impact. Postharvest Biol Technol 29:61–71

    Article  CAS  Google Scholar 

  • Cao G, Sofic E, Prior RL (1997) Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med 22:749–760

    Article  CAS  Google Scholar 

  • Céspedes CL, Valdez-Morales M, Avila JG, EI-Hafidi M, Alarcón J, Paredes-López O (2010) Phytochemical profile and the antioxidant activity of Chilean wild black-berry fruits, Aristotelia chilensis (Mol) Stuntz (Elaeocarpaceae). Food Chem 119:886–895

    Article  Google Scholar 

  • Chen LG, Yang LL, Wang CC (2008) Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol 46:688–693

    Article  CAS  Google Scholar 

  • Chen W, Fu C, Qin Y, Huang D (2009) One-pot depolymerizative extraction of proanthocyanidins from mangosteen pericarps. Food Chem 114:874–880

    Article  CAS  Google Scholar 

  • Chin YW, Jung HA, Chai H, Keller WJ, Kinghorn AD (2008) Xanthones with quinine reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen). Phytochem 69:754–758

    Article  CAS  Google Scholar 

  • Cui J, Hu W, Cai Z, Liu Y, Li S, Tao W, Xiang H (2010) New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L. Pharmacol Biochem Behav 95:166–172

    Article  CAS  Google Scholar 

  • Dangcham S, Bowen J, Ferguson IB, Ketsa S (2008) Effect of temperature and low oxygen on peel hardening of mangosteen fruit stored at low temperature. Postharvest Biol Technol 50:37–44

    Article  CAS  Google Scholar 

  • Destandau E, Toribio A, Lafosse M, Pecher V, Lamy C, André P (2009) Centrifugal partition chromatography directly interfaced with mass spectrometry for the fast screening and fractionation of major xanthones in Garcina mangostana. J Chromatogr A 1216:1390–1394

    Article  CAS  Google Scholar 

  • Devatkal SK, Kamboj R, Paul D (2011) Comparative antioxidant effect of BHT and water extracts of banana and sapodilla peels in raw poultry meat. J Food Sci Technol. doi:10.1007/s13197-011-0508-8

  • Devatkal SK, Thorat P, Manjunatha M (2012) Effect of vacuum packaging and pomegranate peel extract on quality aspects of ground goat meat and nuggets. J Food Sci Technol. doi:10.1007/s13197-012-0753-5

  • Du CT, Francis FJ (1977) Anthocyanins of mangosteen, Garcinia mangostana. J Food Sci 42:1667–1668

    Article  CAS  Google Scholar 

  • Fernández J, Pérez-Álvarez JA, Fernández-López JA (1997) Thiobarbituric acid test for monitoring lipid oxidation in meat. Food Chem 59:345–353

    Article  Google Scholar 

  • Floegel A, Kim DO, Chung SJ, Koo SI, Chun OK (2011) Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. J Food Comp Anal 24:1043–1048

    Article  CAS  Google Scholar 

  • Fu C, Loo AEK, Chai FPP, Huang D (2007) Oligomeric proanthocyanidins from mangosteen pericarps. J Agri Food Chem 55:7689–7694

    Article  CAS  Google Scholar 

  • Fu PP, Chiang HM, Xia Q, Chen T, Chen BH, Yin JJ, Wen KC, Lin G, Yu H (2009) Quality assurance and safety of herbal dietary supplements. J Environ Sci Health Part C 27:91–119

    Article  CAS  Google Scholar 

  • Fu C, Chen W, Quek YL, Ni R, Ghani ABA, Leong WWY, Zeng H, Huang D (2010) Sustainability from agricultural waste: chiral ligands from oligomeric proanthocyanidins via acid-mediated depolymerization. Tetrahedron Lett 51:6322–6324

    Article  CAS  Google Scholar 

  • Garcia VV, Magpantay TO, Escobin LD (2005) Antioxidant potential of selected Philippine vegetables and fruits. Philippine Agr Sci 88:78–83

    Google Scholar 

  • González-Montelongo R, Lobo MG, González M (2009) Antioxidant activity in banana peel extracts: testing extraction conditions and related bioactive compounds. Food Chem 199:1030–1039

    Google Scholar 

  • Gülçin İ, Şat İG, Beydemir Ş, Küfrevioğlu Öİ (2004) Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.). Food Chem 87:393–400

    Article  Google Scholar 

  • Guo C, Yang J, Wei J, Li Y, Xu J, Jiang Y (2003) Antioxidant activities of peel, pulp and seed fractions of common fruits as determined by FRAP assay. Nutr Res 23:1719–1726

    Article  CAS  Google Scholar 

  • Guzmán-Beltrán S, Orozco-Ibarra M, González-Cuahutencos O, Victoria-Mares S, Merchand-Reyes G, Medina-Campos ON, Pedraza-Chaverrí J (2008) Neuroprotective effect and reactive oxygen species scavenging capacity of mangosteen pericarp extract in cultured neurons. Curr Top Nutraceut Res 6:149–158

    Google Scholar 

  • Halliwell B, Gutteridge JMC, Aruoma OI (1987) The deoxyribose method: a simple “test tube” assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem 165:215–219

    Article  CAS  Google Scholar 

  • Heijnen CGM, Haenen GRMM, Vekemans JAJM, Bast A (2001) Peroxynitrite scavenging of flavonoids: structure activity relationship. Environ Toxicol Pharm 10:199–206

    Article  CAS  Google Scholar 

  • Hocman G (1988) Chemoprevention of cancer: phenolic antioxidants (BHT, BHA). Int J Biochem Cell Biol 20:639–651

    CAS  Google Scholar 

  • Huang YL, Chen CC, Chen YJ, Huang RL, Shieh BJ (2001) Three Xanthones and a Benzophenone from Garcinia mangostana. J Nat Prod 64:903–906

    Article  CAS  Google Scholar 

  • Huang D, Ou B, Hampsch-Woodill M, Flanagan JA, Deemer EK (2002) Development and validation of oxygen radical absorbance capacity assay for lipophilic antioxidants using randomly methylated β-cyclodextrin as the solubility enhancer. J Agri Food Chem 50:1815–1821

    Article  CAS  Google Scholar 

  • Iqbal S, Haleem S, Akhtar M, Zia-ul-Haq M, Akbar J (2008) Efficiency of pomegranate peel extracts in stabilization of sunflower oil under accelerated conditions. Food Res Int 41:194–200

    Article  CAS  Google Scholar 

  • Ito N, Fukushima S, Hagiwara A, Shibata M, Ogiso T (1983) Carcinogenicity of butylated hydroxyanisole in F344 rats. J Natl Cancer Inst 70:343–352

    CAS  Google Scholar 

  • Jayasri MA, Mathew L, Radha A (2009) A report on the antioxidant activity of leaves and rhizomes of Costus pictus D. Don. IJIB 5:20–26

    Google Scholar 

  • Ji X, Avula B, Khan IA (2007) Quantitative and qualitative determination of six xanthones in Garcinia mangostana L. by LC–PDA and LC–ESI-MS. J Pharm Biomed Anal 43:1270–1276

    Article  CAS  Google Scholar 

  • Jordan SA, Cunnigham DG, Marles RJ (2010) Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment. Toxicol Appl Pharmacol 243:198–216

    Article  CAS  Google Scholar 

  • Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD (2006) Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agri Food Chem 54:2077–2082

    Article  CAS  Google Scholar 

  • Kedare SB, Singh RP (2011) Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol 48(4):412–422

    Article  CAS  Google Scholar 

  • Ketsa S, Atantee S (1998) Phenolic, lignin, peroxidase activity and increased firmness of damaged pericarp of mangosteen fruit after impact. Postharvest Biol Technol 14:117–124

    Article  CAS  Google Scholar 

  • Khonkarn R, Okonogi S, Ampasavate C, Anuchapreeda S (2010) Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines. Food Chem Toxicol 48:2122–2129

    Article  CAS  Google Scholar 

  • Kosem N, Han YH, Moongkarndi P (2007) Antioxidant and cytoprotective activities of methanolic extract from Garcinia mangostana hulls. ScienceAsia 33:283–292

    Article  CAS  Google Scholar 

  • Lim YY, Lim TT, Tee JJ (2007) Antioxidant properties of several tropical fruits: a comparative study. Food Chem 103:1003–1008

    Article  CAS  Google Scholar 

  • Liu W, Wang H, Yao W, Gao X, Yu L (2010) Effects of sulfation on the physicochemical and functional properties of a water-insoluble polysaccharide preparation from Ganoderma lucidum. J Agric Food Chem 58:3336–3341

    Article  CAS  Google Scholar 

  • Lowry JB, McSweeney CS, Palmer B (1996) Changing perception of the effect of plant phenolics on nutrient supply in the ruminant. Aust J Agr Res 47:829–842

    Article  CAS  Google Scholar 

  • Maisuthisakul P, Suttajit M, Pongsawatmanit R (2007) Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants. Food Chem 100:1409–1418

    Article  CAS  Google Scholar 

  • Mukherjee PK, Maity N, Nema NK, Sarkar BK (2011) Bioactive compounds from natural resources against skin aging. Phytomedicine 19:64–73

    Article  CAS  Google Scholar 

  • Naczk M, Towsend M, Zadernowski R, Shahidi F (2011) Protein-binding and antioxidant potential of phenolics of mangosteen fruit (Garcinia mangostana). Food Chem 128:292–298

    Article  CAS  Google Scholar 

  • Oboh G, Ademosun AO (2011) Characterization of the antioxidant properties of phenolic extracts from some citrus peels. J Food Sci Technol. doi:10.1007/s13197-010-0222-y

  • Okonogi S, Duangrat C, Anuchpreeda S, Tachakittirungrod S, Chowwanapoonpohn S (2007) Comparison of antioxidant capacities and cytotoxicities of certain fruit peels. Food Chem 103:839–846

    Article  CAS  Google Scholar 

  • Palapol Y, Ketsa S, Stevenson D, Cooney JM, Allan AC, Ferguson IB (2009) Colour development and quality of mangosteen (Garcinia mangostana L.) fruit during ripening and after harvest. Postharvest Biol Technol 51:349–353

    Article  CAS  Google Scholar 

  • Pedraza-Chaverrí J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM (2008) Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol 46:3227–3239

    Article  Google Scholar 

  • Pedraza-Chaverrí J, Reyes-Fermín LM, Nolasco-Amaya EG, Orozco-Ibarra M, Medina-Campos ON, González-Cuahutencos O, Rivero-Cruz I, Mata R (2009) ROS scavenging capacity and neuroprotective effect of α-mangostin against 3-nitropropionic acid in cerebellar granule neurons. Exp Toxicol Pathol 61:491–501

    Article  Google Scholar 

  • Pinnell SR (2003) Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 48:1–19

    Article  Google Scholar 

  • Pothitirat W, Chomnawang MT, Supabphol R, Gritsanapan W (2009) Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity. Fitoterapia 80:442–447

    Article  CAS  Google Scholar 

  • Prasad KN, Yang E, Yi C, Zhao M, Jiang Y (2009) Effects of high pressure extraction on the extraction yield, total phenolic content and antioxidant activity of longan fruit pericarp. Innov Food Sci Emerg Technol 10:155–159

    Article  CAS  Google Scholar 

  • Prieto P, Pineda M, Aguilar M (1999) Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem 269:337–341

    Article  CAS  Google Scholar 

  • Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, Hampsch-Woodill M, Huang D, Ou B, Jacob R (2003) Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORACFL)) of plasma and other biological and food samples. J Agri Food Chem 51:3273–3279

    Article  CAS  Google Scholar 

  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS cation decolorization assay. Free Radical Biol Med 26:1231–1237

    Article  CAS  Google Scholar 

  • Schwartz SJ, von Elbe JH, Giusti MM (2007) Colorants. In: Damodaran S, Parkin KL, Fennema OR (eds) Fennema’s food chemistry, 4th edn. CRC, New York, pp 599–610

    Google Scholar 

  • Shahidi F, Naczk M (1995) Antioxidant properties of food phenolics. In: Shahidi F, Naczk M (eds) Food phenolics: sources, chemistry, effects and applications. Technomic Publishing Company Inc, Pennsylvania, pp 235–272

    Google Scholar 

  • Shahidi F, Naczk M (2004) Phenolics in food and nutraceuticals. CRC, Boca Raton

    Google Scholar 

  • Shimamura T, Fujimura Y, Ukeda H (2007) Electron spin resonance analysis of superoxide anion radical scavenging activity with spin trapping agent, diphenyl-PMPO. Anal Sci 23:1233–1235

    Article  CAS  Google Scholar 

  • Shin SG, Kim JY, Chung HY, Jeong JC (2005) Zingerone as an antioxidant against peroxynitrite. J Agri Food Chem 53:7617–7622

    Article  CAS  Google Scholar 

  • Singh J, Sood S, Muthuraman A (2011) In-vitro evaluation of bioactive compounds, anti-oxidant, lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna L. peel extract. J Food Sci Technol. doi:10.1007/s13197-011-0479-9

  • Suksamrarn S, Suwannapoch N, Ratananukul P, Aroonlerk N, Suksamrarn A (2002) Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod 65:761–763

    Article  CAS  Google Scholar 

  • Surveswaran S, Cai YZ, Corke H, Sun M (2007) Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plants. Food Chem 102:938–953

    Article  CAS  Google Scholar 

  • Suttirak W, Manurakchinakorn S (2009) Total phenolic contents and antioxidant activities of mangosteen peel extracts. Proceedings of the 35th Congress on Science and Technology of Thailand (STT 35), Chonburi, Thailand 15–17 October

  • Suvarnakuta P, Chaweerungrat C, Devahastin S (2011) Effects of drying methods on assay and antioxidant activity of xanthones in mangosteen rind. Food Chem 125:240–247

    Article  CAS  Google Scholar 

  • Tachakittirungrod S, Okonogi S, Chowwanapoonpohn S (2007) Study on antioxidant activity of certain plants in Thailand: mechanism of antioxidant action of guava leaf extract. Food Chem 103:381–388

    Article  CAS  Google Scholar 

  • Villaño D, Fernández-Pachón MS, Troncoso AM, García-Parrilla MC (2004) The antioxidant activity of wines determined by the ABTS•+ method: influence of sample dilution and time. Talanta 64:501–509

    Article  Google Scholar 

  • Williams GM (1986) Epigenetic promoting effects of butylated hyroxyanisole. Food Chem Toxicol 24:1163–1166

    Article  CAS  Google Scholar 

  • Wittenauer J, Falk S, Schweiggert-Weisz U, Carle R (2012) Characterisation and quantification of xanthones from the aril and pericarp of mangosteens (Garcinia mangostana L.) and a mangosteen containing functional beverage by HPLC–DAD–MSn. Food Chem 134:455–452

    Article  Google Scholar 

  • Wollgast J, Anklam E (2000) Polyphenols in chocolate: is there a contribution to human health? Food Res Int 33:449–459

    Article  CAS  Google Scholar 

  • Wu LC, Hsu HW, Chen YC, Chiu CC, Lin YI, Ho JA (2006) Antioxidant and antiproliferative activities of red pitaya. Food Chem 95:319–327

    Article  CAS  Google Scholar 

  • Yeh JY, Hsieh LH, Wu KT, Tsai CF (2011) Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola Frondosa (Maitake). Molecules 16:3197–3211

    Article  CAS  Google Scholar 

  • Yoshikawa M, Harada E, Miki A, Tsukamoto K, Liang SQ, Yamahara J, Murakami N (1994) Antioxidant constituents from the fruit hulls of mangosteen (Garcinia mangostana L.) originating in Vietnam. Yakugaku Zasshi 114:129–133

    CAS  Google Scholar 

  • Yu L, Zhao M, Yang B, Zhao Q, Jiang Y (2007) Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities. Food Chem 104:176–181

    Article  CAS  Google Scholar 

  • Zadernowski R, Czaplicki S, Naczk M (2009) Phenolic acid profiles of mangosteen fruits (Garcinia mangostana). Food Chem 112:685–689

    Article  CAS  Google Scholar 

  • Zarena AS, Udaya Sankar K (2009a) A study of antioxidant properties from Garcinia mangostana L. peel extract. Acta Sci Pol 8:23–34

    CAS  Google Scholar 

  • Zarena AS, Udaya Sankar K (2009b) Screening of xanthone from mangosteen (Garcinia mangostana L.) peels and their effect on cytochrome c reductase and phosphomolybdenum activity. J Nat Prod 2:23–30

    CAS  Google Scholar 

  • Zarena AS, Udaya Sankar K (2009c) Supercritical carbon dioxide extraction of xanthones with antioxidant activity from Garcinia mangostana: Characterization by HPLC/LC–ESI-MS. J Supercrit Fluid 49:330–337

    Article  CAS  Google Scholar 

  • Zarena AS, Udaya Sankar K (2011) Xanthones enriched extracts from mangosteen pericarp obtained by supercritical carbon dioxide process. Separ Purif Technol 80:172–178

    Article  CAS  Google Scholar 

  • Zarena AS, Udaya Sankar K (2012) Isolation and identification of pelargonidin 3-glucoside in mangosteen pericarp. Food Chem 130:665–670

    Article  CAS  Google Scholar 

  • Zhang Y, Song Z, Hao J, Qiu S, Xu Z (2010) Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana. Fitoterapia 81:595–599

    Article  CAS  Google Scholar 

  • Zhou HC, Lin YM, Wei SD, Tam NF (2011) Structural diversity and antioxidant activity of condensed tannins fractionated from mangosteen pericarp. Food Chem 129:1710–1720

    Article  CAS  Google Scholar 

  • Zia-ur-Rehman (2006) Citrus peel extract: a natural source of antioxidant. Food Chem 99:450–454

    Article  CAS  Google Scholar 

  • Zou Y, Kim AR, Kim JE, Choi JS, Chung HY (2005) Peroxynitrite scavenging activity of sinapic acid (3,5-Dimethoxy-4-hydroxycinnamic Acid) isolated from Brassica juncea. J Agri Food Chem 50:5884–5890

    Article  Google Scholar 

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  1. School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, Thailand

    Weerayuth Suttirak

  2. School of Agricultural Technology, Walailak University, Nakhon Si Thammarat, 80161, Thailand

    Supranee Manurakchinakorn

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  1. Weerayuth Suttirak
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Suttirak, W., Manurakchinakorn, S. In vitro antioxidant properties of mangosteen peel extract. J Food Sci Technol 51, 3546–3558 (2014). https://doi.org/10.1007/s13197-012-0887-5

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